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Conserved domains on  [gi|303519415|ref|NP_001182000|]
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transmembrane protein 184B isoform a [Homo sapiens]

Protein Classification

OSTA/TMEM184 family protein( domain architecture ID 10508056)

OSTA/TMEM184 family protein such as vertebrate transmembrane proteins 184A, 184B, 184C, and organic solute transporter subunit alpha (OSTA or SLC51A) that is an essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood

Gene Ontology:  GO:0016020
PubMed:  26769966|15563450
TCDB:  2.A.82

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Solute_trans_a pfam03619
Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport ...
 46-319 7.15e-113

Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.


:

Pssm-ID: 460991  Cd Length: 251  Bit Score: 330.24  E-value: 7.15e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415   46 AQAISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFtndQYYVYFGTVRDCYEALVIYN 125
Cdd:pfam03619   1 ALIIAGVFTLLAVLISLYLIFQHLRNYTKPREQRLIIRILLMVPIYAITSFLSLLFP---RAAVYLDPIRDCYEAFVIYS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  126 FLSLCYEYLGGES-SIMSEIRGKPiesscmygtcclwgktySIGFLRFCKQATLQFCVVKPLMAVSTVVLQAFGKYRDGD 204
Cdd:pfam03619  78 FFSLLLEYLGGERkALLRELPGRP-----------------PIKFFRRCKRGVLQYVIVKPLLAILTLILQAFGVYCEGS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  205 FDVTSGYLYVTIIYNISVSLALYALFLFYFATRELLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHsarvS 284
Cdd:pfam03619 141 FSPKFAYLWITIIYNISVTLALYCLVLFYRALKEELKPHKPLLKFLCIKLVIFLSFWQGIIISILASAGVIKCTP----P 216

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 303519415  285 VGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVY 319
Cdd:pfam03619 217 LTAEDIAYGIQNFLICVEMFIFAILHLYAFSYKPY 251
 
Name Accession Description Interval E-value
Solute_trans_a pfam03619
Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport ...
 46-319 7.15e-113

Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.


Pssm-ID: 460991  Cd Length: 251  Bit Score: 330.24  E-value: 7.15e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415   46 AQAISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFtndQYYVYFGTVRDCYEALVIYN 125
Cdd:pfam03619   1 ALIIAGVFTLLAVLISLYLIFQHLRNYTKPREQRLIIRILLMVPIYAITSFLSLLFP---RAAVYLDPIRDCYEAFVIYS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  126 FLSLCYEYLGGES-SIMSEIRGKPiesscmygtcclwgktySIGFLRFCKQATLQFCVVKPLMAVSTVVLQAFGKYRDGD 204
Cdd:pfam03619  78 FFSLLLEYLGGERkALLRELPGRP-----------------PIKFFRRCKRGVLQYVIVKPLLAILTLILQAFGVYCEGS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  205 FDVTSGYLYVTIIYNISVSLALYALFLFYFATRELLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHsarvS 284
Cdd:pfam03619 141 FSPKFAYLWITIIYNISVTLALYCLVLFYRALKEELKPHKPLLKFLCIKLVIFLSFWQGIIISILASAGVIKCTP----P 216

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 303519415  285 VGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVY 319
Cdd:pfam03619 217 LTAEDIAYGIQNFLICVEMFIFAILHLYAFSYKPY 251
 
Name Accession Description Interval E-value
Solute_trans_a pfam03619
Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport ...
 46-319 7.15e-113

Organic solute transporter Ostalpha; This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.


Pssm-ID: 460991  Cd Length: 251  Bit Score: 330.24  E-value: 7.15e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415   46 AQAISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFtndQYYVYFGTVRDCYEALVIYN 125
Cdd:pfam03619   1 ALIIAGVFTLLAVLISLYLIFQHLRNYTKPREQRLIIRILLMVPIYAITSFLSLLFP---RAAVYLDPIRDCYEAFVIYS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  126 FLSLCYEYLGGES-SIMSEIRGKPiesscmygtcclwgktySIGFLRFCKQATLQFCVVKPLMAVSTVVLQAFGKYRDGD 204
Cdd:pfam03619  78 FFSLLLEYLGGERkALLRELPGRP-----------------PIKFFRRCKRGVLQYVIVKPLLAILTLILQAFGVYCEGS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303519415  205 FDVTSGYLYVTIIYNISVSLALYALFLFYFATRELLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHsarvS 284
Cdd:pfam03619 141 FSPKFAYLWITIIYNISVTLALYCLVLFYRALKEELKPHKPLLKFLCIKLVIFLSFWQGIIISILASAGVIKCTP----P 216

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 303519415  285 VGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVY 319
Cdd:pfam03619 217 LTAEDIAYGIQNFLICVEMFIFAILHLYAFSYKPY 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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