|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
633-775 |
5.64e-33 |
|
Toll - interleukin 1 - resistance;
:
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 123.97 E-value: 5.64e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 633 RFHAFISYSEHDslWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 306140493 713 AHHNLFHENSDHIILILLEPIPFYcIPTRYHKLKALLeKKAYLEWPKDRRKcgLFWANLRAAI 775
Cdd:smart00255 79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKE--QFWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
348-524 |
1.80e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.51 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTDeLFKRTIQLPHLKTLILNGNKLETLSlvSCFANNTPLEHLDLSQNLLQHKNDENCSWPEtVVNMN 427
Cdd:COG4886 113 TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELD 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 428 LSYNKLSDsvfrcLPKSI------QILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFIl 501
Cdd:COG4886 189 LSNNQITD-----LPEPLgnltnlEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL- 262
|
170 180
....*....|....*....|...
gi 306140493 502 sPSLDFVQSCQEVKTLNAGRNPF 524
Cdd:COG4886 263 -TDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
72-129 |
3.50e-10 |
|
Leucine rich repeat;
:
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 3.50e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 306140493 72 SKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV---TWYLLAGLRYLDLSFNDF 129
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLspgAFSGLPSLRYLDLSGNRL 61
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
33-267 |
7.66e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 7.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 33 NCSNMSLRKVPADLTPAT--TTLDLSYNLLFQLqSSDFHSVSKLRVLILCHNRIQQLDlKTFEFNKELRYLDLSNNRLKS 110
Cdd:COG4886 165 DLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 111 VTW-YLLAGLRYLDLSFNDFDTMPiceEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEE----GSL 185
Cdd:COG4886 243 LPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEllilLLL 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 186 PILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQF 265
Cdd:COG4886 320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
|
..
gi 306140493 266 VW 267
Cdd:COG4886 400 VL 401
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
522-574 |
2.34e-05 |
|
Leucine rich repeat C-terminal domain;
:
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 42.42 E-value: 2.34e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306140493 522 NPFRCTCELKNFIQLETYSEvmMVGWSDSYTCEYPLNLRGtRLKDVHLHELSC 574
Cdd:smart00082 1 NPFICDCELRWLLRWLQANE--HLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
633-775 |
5.64e-33 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 123.97 E-value: 5.64e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 633 RFHAFISYSEHDslWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 306140493 713 AHHNLFHENSDHIILILLEPIPFYcIPTRYHKLKALLeKKAYLEWPKDRRKcgLFWANLRAAI 775
Cdd:smart00255 79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKE--QFWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
634-768 |
1.29e-17 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 80.87 E-value: 1.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 634 FHAFISYSEHDSL-WVKNELIPNLEKEdgSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712
Cdd:pfam01582 1 YDVFLSFRGSDTReWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 306140493 713 AHHNLFhENSDHIILILLEPIPFYC------IPTRYHKLKALLEKKAYLEWPKDRRKCGLFW 768
Cdd:pfam01582 79 ILECAL-DLGQKVIPIFYEVDPSDVrkqtgsFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
348-524 |
1.80e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.51 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTDeLFKRTIQLPHLKTLILNGNKLETLSlvSCFANNTPLEHLDLSQNLLQHKNDENCSWPEtVVNMN 427
Cdd:COG4886 113 TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELD 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 428 LSYNKLSDsvfrcLPKSI------QILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFIl 501
Cdd:COG4886 189 LSNNQITD-----LPEPLgnltnlEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL- 262
|
170 180
....*....|....*....|...
gi 306140493 502 sPSLDFVQSCQEVKTLNAGRNPF 524
Cdd:COG4886 263 -TDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
72-129 |
3.50e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 3.50e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 306140493 72 SKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV---TWYLLAGLRYLDLSFNDF 129
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLspgAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
33-267 |
7.66e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 7.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 33 NCSNMSLRKVPADLTPAT--TTLDLSYNLLFQLqSSDFHSVSKLRVLILCHNRIQQLDlKTFEFNKELRYLDLSNNRLKS 110
Cdd:COG4886 165 DLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 111 VTW-YLLAGLRYLDLSFNDFDTMPiceEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEE----GSL 185
Cdd:COG4886 243 LPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEllilLLL 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 186 PILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQF 265
Cdd:COG4886 320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
|
..
gi 306140493 266 VW 267
Cdd:COG4886 400 VL 401
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
367-482 |
1.94e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 367 RTIQLPH-----LKTLILNGNKL--------ETLSLVSCFANN--TPLEHLDLSQNLLQHKNDENCSWPETVvNMNLSYN 431
Cdd:PRK15370 252 RITELPErlpsaLQSLDLFHNKIsclpenlpEELRYLSVYDNSirTLPAHLPSGITHLNVQSNSLTALPETL-PPGLKTL 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 306140493 432 KLSDSVFRCLPKSI----QILDLNNNQIQTVPkETIHlMALRELNIAFNFLTDLP 482
Cdd:PRK15370 331 EAGENALTSLPASLppelQVLDVSKNQITVLP-ETLP-PTITTLDVSRNALTNLP 383
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
51-155 |
1.04e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.86 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 51 TTLDLSYNLLFQlqssdfhSVSKLRVLILCHNRIQQLDlKTFEFNKELRYLDLSNNRLKSVTWYL--LAGLRYLDLSFND 128
Cdd:COG4886 99 TELDLSGNEELS-------NLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLgnLTNLKSLDLSNNQ 170
|
90 100
....*....|....*....|....*..
gi 306140493 129 FDTMPicEEAGNMSHLEILGLSGAKIQ 155
Cdd:COG4886 171 LTDLP--EELGNLTNLKELDLSNNQIT 195
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
372-455 |
7.65e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 7.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 372 PHLKTLILNGNKLETLSlVSCFANNTPLEHLDLSQNLLQHkndencswpetvvnmnlsynkLSDSVFRCLPkSIQILDLN 451
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLP-SLRYLDLS 57
|
....
gi 306140493 452 NNQI 455
Cdd:pfam13855 58 GNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
348-455 |
8.64e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 48.51 E-value: 8.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTDELFKRTIQ----LPHLKTLILNGNKLETL---SLVSCFANNTPLEHLDLSQNLL-----QHKNDE 415
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGLTDEgasALAETLASLKSLEVLNLGDNNLtdagaAALASA 244
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 306140493 416 NCSWPETVVNMNLSYNKLSDSVFRCL------PKSIQILDLNNNQI 455
Cdd:cd00116 245 LLSPNISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKF 290
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
522-574 |
2.34e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 42.42 E-value: 2.34e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306140493 522 NPFRCTCELKNFIQLETYSEvmMVGWSDSYTCEYPLNLRGtRLKDVHLHELSC 574
Cdd:smart00082 1 NPFICDCELRWLLRWLQANE--HLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
24-133 |
9.67e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.84 E-value: 9.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 24 LPEE-----RELMTNCSNMSlrKVPADLTPATTTLDLSYNLLFQLQSsdfHSVSKLRVLILCHNRIQQLDLKTFEfnkEL 98
Cdd:PRK15370 214 LPENlqgniKTLYANSNQLT--SIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPE---EL 285
|
90 100 110
....*....|....*....|....*....|....*
gi 306140493 99 RYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMP 133
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
51-151 |
1.27e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 44.01 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 51 TTLDLSYNLLFQLQssDFHSVSKLRVLILCHNRI-------------------QQLDLK-TFEFN--------KELRYLD 102
Cdd:cd21340 49 THLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIsvveglenltnleelhienQRLPPGeKLTFDprslaalsNSLRVLN 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 306140493 103 LSNNRLKSVTW-YLLAGLRYLDLSFNDFDTM-PICEEAGNMSHLEILGLSG 151
Cdd:cd21340 127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTG 177
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
633-775 |
5.64e-33 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 123.97 E-value: 5.64e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 633 RFHAFISYSEHDslWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 306140493 713 AHHNLFHENSDHIILILLEPIPFYcIPTRYHKLKALLeKKAYLEWPKDRRKcgLFWANLRAAI 775
Cdd:smart00255 79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKE--QFWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
634-768 |
1.29e-17 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 80.87 E-value: 1.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 634 FHAFISYSEHDSL-WVKNELIPNLEKEdgSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYF 712
Cdd:pfam01582 1 YDVFLSFRGSDTReWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 306140493 713 AHHNLFhENSDHIILILLEPIPFYC------IPTRYHKLKALLEKKAYLEWPKDRRKCGLFW 768
Cdd:pfam01582 79 ILECAL-DLGQKVIPIFYEVDPSDVrkqtgsFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
348-524 |
1.80e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.51 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTDeLFKRTIQLPHLKTLILNGNKLETLSlvSCFANNTPLEHLDLSQNLLQHKNDENCSWPEtVVNMN 427
Cdd:COG4886 113 TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELD 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 428 LSYNKLSDsvfrcLPKSI------QILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFIl 501
Cdd:COG4886 189 LSNNQITD-----LPEPLgnltnlEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL- 262
|
170 180
....*....|....*....|...
gi 306140493 502 sPSLDFVQSCQEVKTLNAGRNPF 524
Cdd:COG4886 263 -TDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
348-541 |
4.07e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 72.27 E-value: 4.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTD---ELFkrtiQLPHLKTLILNGNKLETLSLVscFANNTPLEHLDLSQNLLQhkndencSWPETVV 424
Cdd:COG4886 136 TNLKELDLSNNQLTDlpePLG----NLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQIT-------DLPEPLG 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 425 NM------NLSYNKLSDsvfrcLPKSI------QILDLNNNQIQTVPkETIHLMALRELNIAFNFLTDLPGCSHFSRLSV 492
Cdd:COG4886 203 NLtnleelDLSGNQLTD-----LPEPLanltnlETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 306140493 493 LNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSE 541
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLL 325
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
72-129 |
3.50e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 3.50e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 306140493 72 SKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV---TWYLLAGLRYLDLSFNDF 129
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLspgAFSGLPSLRYLDLSGNRL 61
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
637-732 |
5.91e-10 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 57.33 E-value: 5.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 637 FISYSEHDSLWVKnELIPNLEKEDgsiliclYESYFD-----PGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFY 711
Cdd:pfam13676 2 FISYAGEDRAWAE-WLADALEAAG-------YRVWLDrwdirPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
|
90 100
....*....|....*....|.
gi 306140493 712 FAHHnlFHENSDHIILILLEP 732
Cdd:pfam13676 74 AALA--DPEGRKRLIPVRLEC 92
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
33-267 |
7.66e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.79 E-value: 7.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 33 NCSNMSLRKVPADLTPAT--TTLDLSYNLLFQLqSSDFHSVSKLRVLILCHNRIQQLDlKTFEFNKELRYLDLSNNRLKS 110
Cdd:COG4886 165 DLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 111 VTW-YLLAGLRYLDLSFNDFDTMPiceEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEE----GSL 185
Cdd:COG4886 243 LPElGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEllilLLL 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 186 PILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQF 265
Cdd:COG4886 320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
|
..
gi 306140493 266 VW 267
Cdd:COG4886 400 VL 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
51-108 |
1.16e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 1.16e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 306140493 51 TTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRL 108
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
367-482 |
1.94e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 367 RTIQLPH-----LKTLILNGNKL--------ETLSLVSCFANN--TPLEHLDLSQNLLQHKNDENCSWPETVvNMNLSYN 431
Cdd:PRK15370 252 RITELPErlpsaLQSLDLFHNKIsclpenlpEELRYLSVYDNSirTLPAHLPSGITHLNVQSNSLTALPETL-PPGLKTL 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 306140493 432 KLSDSVFRCLPKSI----QILDLNNNQIQTVPkETIHlMALRELNIAFNFLTDLP 482
Cdd:PRK15370 331 EAGENALTSLPASLppelQVLDVSKNQITVLP-ETLP-PTITTLDVSRNALTNLP 383
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
51-155 |
1.04e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.86 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 51 TTLDLSYNLLFQlqssdfhSVSKLRVLILCHNRIQQLDlKTFEFNKELRYLDLSNNRLKSVTWYL--LAGLRYLDLSFND 128
Cdd:COG4886 99 TELDLSGNEELS-------NLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLgnLTNLKSLDLSNNQ 170
|
90 100
....*....|....*....|....*..
gi 306140493 129 FDTMPicEEAGNMSHLEILGLSGAKIQ 155
Cdd:COG4886 171 LTDLP--EELGNLTNLKELDLSNNQIT 195
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
372-455 |
7.65e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 7.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 372 PHLKTLILNGNKLETLSlVSCFANNTPLEHLDLSQNLLQHkndencswpetvvnmnlsynkLSDSVFRCLPkSIQILDLN 451
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTT---------------------LSPGAFSGLP-SLRYLDLS 57
|
....
gi 306140493 452 NNQI 455
Cdd:pfam13855 58 GNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
348-455 |
8.64e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 48.51 E-value: 8.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNFANNILTDELFKRTIQ----LPHLKTLILNGNKLETL---SLVSCFANNTPLEHLDLSQNLL-----QHKNDE 415
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGLTDEgasALAETLASLKSLEVLNLGDNNLtdagaAALASA 244
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 306140493 416 NCSWPETVVNMNLSYNKLSDSVFRCL------PKSIQILDLNNNQI 455
Cdd:cd00116 245 LLSPNISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKF 290
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
522-574 |
2.34e-05 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 42.42 E-value: 2.34e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306140493 522 NPFRCTCELKNFIQLETYSEvmMVGWSDSYTCEYPLNLRGtRLKDVHLHELSC 574
Cdd:smart00082 1 NPFICDCELRWLLRWLQANE--HLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
24-133 |
9.67e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.84 E-value: 9.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 24 LPEE-----RELMTNCSNMSlrKVPADLTPATTTLDLSYNLLFQLQSsdfHSVSKLRVLILCHNRIQQLDLKTFEfnkEL 98
Cdd:PRK15370 214 LPENlqgniKTLYANSNQLT--SIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPE---EL 285
|
90 100 110
....*....|....*....|....*....|....*
gi 306140493 99 RYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMP 133
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP 320
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
51-151 |
1.27e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 44.01 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 51 TTLDLSYNLLFQLQssDFHSVSKLRVLILCHNRI-------------------QQLDLK-TFEFN--------KELRYLD 102
Cdd:cd21340 49 THLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIsvveglenltnleelhienQRLPPGeKLTFDprslaalsNSLRVLN 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 306140493 103 LSNNRLKSVTW-YLLAGLRYLDLSFNDFDTM-PICEEAGNMSHLEILGLSG 151
Cdd:cd21340 127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTG 177
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
348-501 |
1.44e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 42.14 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 348 TKFQYLNF---ANNILTDELFKRTIQLPHLKTLILNGNK-------------LETLSLV---------SCFANNTPLEHL 402
Cdd:PLN00113 425 TKLPLVYFldiSNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavpRKLGSLSELMQL 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 403 DLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSV---FRCLPkSIQILDLNNNQIQ-TVPKETIHLMALRELNIAFNFL 478
Cdd:PLN00113 505 KLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIpasFSEMP-VLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
|
170 180
....*....|....*....|....
gi 306140493 479 -TDLPGCSHFSRLSVLNIEMNFIL 501
Cdd:PLN00113 584 hGSLPSTGAFLAINASAVAGNIDL 607
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
351-409 |
2.14e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 2.14e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 306140493 351 QYLNFANNILT---DELFKRtiqLPHLKTLILNGNKLETLSLVScFANNTPLEHLDLSQNLL 409
Cdd:pfam13855 4 RSLDLSNNRLTsldDGAFKG---LSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
59-135 |
9.47e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 38.23 E-value: 9.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306140493 59 LLFQLQSSDFHSVSkLRVLILCHNRIQqlDLKTFEFNKELRYLDLSNNRLKS---VTWYL--LAGLRYLDLSFNdfdtmP 133
Cdd:cd21340 108 LTFDPRSLAALSNS-LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDleeLLDLLssWPSLRELDLTGN-----P 179
|
..
gi 306140493 134 IC 135
Cdd:cd21340 180 VC 181
|
|
| |
