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Conserved domains on  [gi|305410866|ref|NP_001182190|]
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myomegalin isoform 7 [Homo sapiens]

Protein Classification

Cnn_1N and PRK12704 domain-containing protein( domain architecture ID 10546816)

Cnn_1N and PRK12704 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 13-76 5.62e-15

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


:

Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 66.01  E-value: 5.62e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305410866   13 EHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 76
Cdd:pfam07989   5 KQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 super family cl36166
phosphodiesterase; Provisional
 37-148 5.73e-03

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 36.29  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410866  37 QQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS---QNEAELRRQFEERQQETEHVYELLENKIQ 113
Cdd:PRK12704  63 KEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEeleKKEKELEQKQQELEKKEEELEELIEEQLQ 142

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 305410866 114 LLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 148
Cdd:PRK12704 143 ELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 13-76 5.62e-15

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 66.01  E-value: 5.62e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305410866   13 EHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 76
Cdd:pfam07989   5 KQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 PRK12704
phosphodiesterase; Provisional
 37-148 5.73e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 36.29  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410866  37 QQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS---QNEAELRRQFEERQQETEHVYELLENKIQ 113
Cdd:PRK12704  63 KEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEeleKKEKELEQKQQELEKKEEELEELIEEQLQ 142

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 305410866 114 LLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 148
Cdd:PRK12704 143 ELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
 13-76 5.62e-15

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 66.01  E-value: 5.62e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305410866   13 EHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 76
Cdd:pfam07989   5 KQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
PRK12704 PRK12704
phosphodiesterase; Provisional
 37-148 5.73e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 36.29  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305410866  37 QQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS---QNEAELRRQFEERQQETEHVYELLENKIQ 113
Cdd:PRK12704  63 KEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEeleKKEKELEQKQQELEKKEEELEELIEEQLQ 142

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 305410866 114 LLQEESRLAKNEAARMaALVEAEKECNLELSEKLK 148
Cdd:PRK12704 143 ELERISGLTAEEAKEI-LLEKVEEEARHEAAVLIK 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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