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Conserved domains on  [gi|306035177|ref|NP_001182231|]
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U6 snRNA phosphodiesterase 1 isoform 2 [Homo sapiens]

Protein Classification

HVSL domain-containing protein( domain architecture ID 12101698)

U6 snRNA phosphodiesterase is a 3' to 5' exoribonuclease responsible for 3'-end maturation of U6 snRNA; similar to human U6 snRNA phosphodiesterase USB1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HVSL pfam09749
Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues ...
44-245 1.08e-72

Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues conserved from plants to humans. It contains two conserved motifs, HxSL and FHVSL. The function is unknown.


:

Pssm-ID: 462880  Cd Length: 238  Bit Score: 221.77  E-value: 1.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177   44 PVPDSVLNMFPGTEE-GPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLLDVLLPHAQTYVPRLVRMKV---- 118
Cdd:pfam09749   2 PLPDSFLDLYASTPRtSTEDDPSLHGGRKRSFPHVEGNWPTHVYIEWHPSESERELLSELLKQVQEELGSSVKLHSllts 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177  119 -------FHLSLSQSVVLRHHWILPFVQALKARMTSFH--------------------RTFIGLEVT-SGHAQFLDLVSE 170
Cdd:pfam09749  82 dlgvplpLHISLSRTVVLRTHQIDSFLDSLKKALKSSAirpfsvqfsglkwyvndektRTFLVLRVVsPGNDELKKLLDA 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 306035177  171 VDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVD--GFEDAEVLLRVHTEQVRCKSGNKFFSMP 245
Cdd:pfam09749 162 INEVLKEFGLPPLYKDPSFHISIAWSLGDPSEELKEELLQELQSLLKdnEFLESSKLLRIKFNSVKCKIGNKVFSIP 238
 
Name Accession Description Interval E-value
HVSL pfam09749
Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues ...
44-245 1.08e-72

Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues conserved from plants to humans. It contains two conserved motifs, HxSL and FHVSL. The function is unknown.


Pssm-ID: 462880  Cd Length: 238  Bit Score: 221.77  E-value: 1.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177   44 PVPDSVLNMFPGTEE-GPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLLDVLLPHAQTYVPRLVRMKV---- 118
Cdd:pfam09749   2 PLPDSFLDLYASTPRtSTEDDPSLHGGRKRSFPHVEGNWPTHVYIEWHPSESERELLSELLKQVQEELGSSVKLHSllts 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177  119 -------FHLSLSQSVVLRHHWILPFVQALKARMTSFH--------------------RTFIGLEVT-SGHAQFLDLVSE 170
Cdd:pfam09749  82 dlgvplpLHISLSRTVVLRTHQIDSFLDSLKKALKSSAirpfsvqfsglkwyvndektRTFLVLRVVsPGNDELKKLLDA 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 306035177  171 VDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVD--GFEDAEVLLRVHTEQVRCKSGNKFFSMP 245
Cdd:pfam09749 162 INEVLKEFGLPPLYKDPSFHISIAWSLGDPSEELKEELLQELQSLLKdnEFLESSKLLRIKFNSVKCKIGNKVFSIP 238
 
Name Accession Description Interval E-value
HVSL pfam09749
Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues ...
44-245 1.08e-72

Uncharacterized conserved protein; This entry is of proteins of approximately 300 residues conserved from plants to humans. It contains two conserved motifs, HxSL and FHVSL. The function is unknown.


Pssm-ID: 462880  Cd Length: 238  Bit Score: 221.77  E-value: 1.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177   44 PVPDSVLNMFPGTEE-GPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLLDVLLPHAQTYVPRLVRMKV---- 118
Cdd:pfam09749   2 PLPDSFLDLYASTPRtSTEDDPSLHGGRKRSFPHVEGNWPTHVYIEWHPSESERELLSELLKQVQEELGSSVKLHSllts 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306035177  119 -------FHLSLSQSVVLRHHWILPFVQALKARMTSFH--------------------RTFIGLEVT-SGHAQFLDLVSE 170
Cdd:pfam09749  82 dlgvplpLHISLSRTVVLRTHQIDSFLDSLKKALKSSAirpfsvqfsglkwyvndektRTFLVLRVVsPGNDELKKLLDA 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 306035177  171 VDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVD--GFEDAEVLLRVHTEQVRCKSGNKFFSMP 245
Cdd:pfam09749 162 INEVLKEFGLPPLYKDPSFHISIAWSLGDPSEELKEELLQELQSLLKdnEFLESSKLLRIKFNSVKCKIGNKVFSIP 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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