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Conserved domains on  [gi|308199448|ref|NP_001184052|]
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interferon regulatory factor 3 isoform 3 [Homo sapiens]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10209994)

IRF and IRF-3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 167-345 7.08e-75

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 230.22  E-value: 7.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  167 WEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL-----PGWPVTLPDPGMsLTDRGVMSYVRHVLSCLGGGLALWR 241
Cdd:pfam10401   2 TDLEITFFYRGRLVLELTVSSPEGCRLSYGPPDPQVAlygpvALQQVRFPDPDG-IPDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  242 AGQWLWAQRLGHCHTYWAVSEELLPnsgHGPDgEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ 321
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGG---DKPN-KLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDK 156

                         170       180
                  ....*....|....*....|....
gi 308199448  322 PWTKRLVMVKVVPTCLRALVEMAR 345
Cdd:pfam10401 157 PREKKLITVQVVPLFARQLLEMAS 180
IRF super family cl00096
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 21-75 2.54e-21

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


The actual alignment was detected with superfamily member pfam00605:

Pssm-ID: 469613  Cd Length: 106  Bit Score: 88.00  E-value: 2.54e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 308199448   21 AWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSK-DPHDPHKIYEFV 75
Cdd:pfam00605  51 AWAVHTGKYREGVDKPDPATWKTNFRCALNKLPDFEEVKDRSKdDGSDPYKVYRIL 106
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 167-345 7.08e-75

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 230.22  E-value: 7.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  167 WEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL-----PGWPVTLPDPGMsLTDRGVMSYVRHVLSCLGGGLALWR 241
Cdd:pfam10401   2 TDLEITFFYRGRLVLELTVSSPEGCRLSYGPPDPQVAlygpvALQQVRFPDPDG-IPDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  242 AGQWLWAQRLGHCHTYWAVSEELLPnsgHGPDgEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ 321
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGG---DKPN-KLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDK 156

                         170       180
                  ....*....|....*....|....
gi 308199448  322 PWTKRLVMVKVVPTCLRALVEMAR 345
Cdd:pfam10401 157 PREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 21-75 2.54e-21

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 88.00  E-value: 2.54e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 308199448   21 AWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSK-DPHDPHKIYEFV 75
Cdd:pfam00605  51 AWAVHTGKYREGVDKPDPATWKTNFRCALNKLPDFEEVKDRSKdDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 21-77 1.07e-17

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 78.14  E-value: 1.07e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 308199448    21 AWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNS 77
Cdd:smart00348  51 AYCVARGIYQPGGRSPDPKTWKARLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 21-75 1.74e-13

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 66.16  E-value: 1.74e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 308199448  21 AWAEATGAYVPGrDKPDLPTWKRNFRSALNRKEGLRLAEDRSKD-PHDPHKIYEFV 75
Cdd:cd00103   52 AWAVERGIYQPG-GTPDPAEWKARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLL 106
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 167-345 7.08e-75

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 230.22  E-value: 7.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  167 WEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL-----PGWPVTLPDPGMsLTDRGVMSYVRHVLSCLGGGLALWR 241
Cdd:pfam10401   2 TDLEITFFYRGRLVLELTVSSPEGCRLSYGPPDPQVAlygpvALQQVRFPDPDG-IPDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199448  242 AGQWLWAQRLGHCHTYWAVSEELLPnsgHGPDgEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ 321
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGG---DKPN-KLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDK 156

                         170       180
                  ....*....|....*....|....
gi 308199448  322 PWTKRLVMVKVVPTCLRALVEMAR 345
Cdd:pfam10401 157 PREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 21-75 2.54e-21

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 88.00  E-value: 2.54e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 308199448   21 AWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSK-DPHDPHKIYEFV 75
Cdd:pfam00605  51 AWAVHTGKYREGVDKPDPATWKTNFRCALNKLPDFEEVKDRSKdDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 21-77 1.07e-17

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 78.14  E-value: 1.07e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 308199448    21 AWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNS 77
Cdd:smart00348  51 AYCVARGIYQPGGRSPDPKTWKARLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 21-75 1.74e-13

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 66.16  E-value: 1.74e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 308199448  21 AWAEATGAYVPGrDKPDLPTWKRNFRSALNRKEGLRLAEDRSKD-PHDPHKIYEFV 75
Cdd:cd00103   52 AWAVERGIYQPG-GTPDPAEWKARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRLL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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