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Conserved domains on  [gi|308199450|ref|NP_001184053|]
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interferon regulatory factor 3 isoform 4 [Homo sapiens]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10457094)

IRF and IRF-3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-110 2.56e-52

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 166.97  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450    7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQD-AQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALN 85
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDwNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 308199450   86 RKEGLRLAEDRSK-DPHDPHKIYEFV 110
Cdd:pfam00605  81 KLPDFEEVKDRSKdDGSDPYKVYRIL 106
IRF-3 super family cl11061
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 200-253 1.09e-21

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


The actual alignment was detected with superfamily member pfam10401:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 89.62  E-value: 1.09e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 308199450  200 EDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMAR 253
Cdd:pfam10401 127 RELILFQEGRGRSPDYTITLCFGEEWPDDKPREKKLITVQVVPLFARQLLEMAS 180
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-110 2.56e-52

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 166.97  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450    7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQD-AQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALN 85
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDwNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 308199450   86 RKEGLRLAEDRSK-DPHDPHKIYEFV 110
Cdd:pfam00605  81 KLPDFEEVKDRSKdDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 7-112 1.97e-45

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 149.41  E-value: 1.97e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450     7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-DFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALN 85
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEErDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 308199450    86 RKEGLRLAEDRSKDPHDPHKIYEFVNS 112
Cdd:smart00348  81 KSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 5-110 1.04e-42

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 142.43  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450   5 KPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGrDKPDLPTWKRNFRSAL 84
Cdd:cd00103    1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCAL 79

                         90       100
                 ....*....|....*....|....*..
gi 308199450  85 NRKEGLRLAEDRSKD-PHDPHKIYEFV 110
Cdd:cd00103   80 RSSRGFEEVKDKSKDtPGDPHRVYRLL 106
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 200-253 1.09e-21

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 89.62  E-value: 1.09e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 308199450  200 EDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMAR 253
Cdd:pfam10401 127 RELILFQEGRGRSPDYTITLCFGEEWPDDKPREKKLITVQVVPLFARQLLEMAS 180
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 7-110 2.56e-52

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 166.97  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450    7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQD-AQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALN 85
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDwNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 308199450   86 RKEGLRLAEDRSK-DPHDPHKIYEFV 110
Cdd:pfam00605  81 KLPDFEEVKDRSKdDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 7-112 1.97e-45

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 149.41  E-value: 1.97e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450     7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-DFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALN 85
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEErDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 308199450    86 RKEGLRLAEDRSKDPHDPHKIYEFVNS 112
Cdd:smart00348  81 KSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 5-110 1.04e-42

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 142.43  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308199450   5 KPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGrDKPDLPTWKRNFRSAL 84
Cdd:cd00103    1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCAL 79

                         90       100
                 ....*....|....*....|....*..
gi 308199450  85 NRKEGLRLAEDRSKD-PHDPHKIYEFV 110
Cdd:cd00103   80 RSSRGFEEVKDKSKDtPGDPHRVYRLL 106
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 200-253 1.09e-21

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 89.62  E-value: 1.09e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 308199450  200 EDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMAR 253
Cdd:pfam10401 127 RELILFQEGRGRSPDYTITLCFGEEWPDDKPREKKLITVQVVPLFARQLLEMAS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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