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Conserved domains on  [gi|308737003|ref|NP_001184188|]
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origin recognition complex subunit 3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 212-442 1.93e-146

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


:

Pssm-ID: 466140  Cd Length: 233  Bit Score: 421.11  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  212 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 291
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  292 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 369
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308737003  370 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 442
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 1-201 2.44e-114

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


:

Pssm-ID: 462070  Cd Length: 330  Bit Score: 342.79  E-value: 2.44e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003    1 MKHFLQKLISQLMDCCVDIKSKEE----ESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVI 75
Cdd:pfam07034 125 LKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVI 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003   76 LKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQF 155
Cdd:pfam07034 205 FKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQF 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 308737003  156 PFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 201
Cdd:pfam07034 285 PFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 431-565 9.07e-56

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


:

Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 192.39  E-value: 9.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003 431 PLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKS-EEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAF 509
Cdd:cd20704  242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCECCKSdDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308737003 510 ATVVTAAEKMD----------ANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704  322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
 
Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 212-442 1.93e-146

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 421.11  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  212 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 291
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  292 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 369
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308737003  370 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 442
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 1-201 2.44e-114

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 342.79  E-value: 2.44e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003    1 MKHFLQKLISQLMDCCVDIKSKEE----ESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVI 75
Cdd:pfam07034 125 LKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVI 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003   76 LKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQF 155
Cdd:pfam07034 205 FKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQF 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 308737003  156 PFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 201
Cdd:pfam07034 285 PFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 61-201 1.41e-56

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 194.70  E-value: 1.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  61 RTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKE 140
Cdd:cd20704  101 KSLISQFIGQPLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSSSD 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308737003 141 HLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 201
Cdd:cd20704  181 YLERVLEKVLLDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 431-565 9.07e-56

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 192.39  E-value: 9.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003 431 PLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKS-EEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAF 509
Cdd:cd20704  242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCECCKSdDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308737003 510 ATVVTAAEKMD----------ANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704  322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
 453-565 5.97e-40

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 141.67  E-value: 5.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  453 RIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKM------------ 519
Cdd:pfam18137   1 RSTIESALLNPEDYLRCECCDdSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELvrlreaakegkd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 308737003  520 -----DANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:pfam18137  81 kdaekDADEEDDEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Name Accession Description Interval E-value
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
 212-442 1.93e-146

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 421.11  E-value: 1.93e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  212 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 291
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  292 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 369
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308737003  370 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 442
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
 1-201 2.44e-114

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 342.79  E-value: 2.44e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003    1 MKHFLQKLISQLMDCCVDIKSKEE----ESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVI 75
Cdd:pfam07034 125 LKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKSLRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVI 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003   76 LKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQF 155
Cdd:pfam07034 205 FKDLESFSAKVLQDFILILSSYLSELPLVFVFGVATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQF 284

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 308737003  156 PFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 201
Cdd:pfam07034 285 PFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLALLEHFYSQPLSVL 330
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 61-201 1.41e-56

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 194.70  E-value: 1.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  61 RTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKE 140
Cdd:cd20704  101 KSLISQFIGQPLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSSSD 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308737003 141 HLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 201
Cdd:cd20704  181 YLERVLEKVLLDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
 431-565 9.07e-56

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 192.39  E-value: 9.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003 431 PLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKS-EEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAF 509
Cdd:cd20704  242 PLHEIFYFDDVSPLRSALIPSPRAAIETALLNPHDYLQCECCKSdDDGLILSTLPDTSILYKLYLESGRLINVYDWYQAF 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308737003 510 ATVVTAAEKMD----------ANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:cd20704  322 KTVLEPEEEEEkekkesseekEDEEDEEEWEKELQARFIRAVAELQFLGFIKPTKRKTDHVARLTW 387
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
 453-565 5.97e-40

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 141.67  E-value: 5.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308737003  453 RIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKM------------ 519
Cdd:pfam18137   1 RSTIESALLNPEDYLRCECCDdSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELvrlreaakegkd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 308737003  520 -----DANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 565
Cdd:pfam18137  81 kdaekDADEEDDEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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