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Conserved domains on  [gi|308818204|ref|NP_001184224|]
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extracellular matrix protein 2 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-651 4.92e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 4.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 308818204 608 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 651
Cdd:COG4886  321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 1.05e-14

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.61  E-value: 1.05e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818204  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-651 4.92e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 4.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 308818204 608 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 651
Cdd:COG4886  321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
298-550 1.09e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 298 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 376
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 377 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 442
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 443 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 520
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 308818204 521 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 1.05e-14

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.61  E-value: 1.05e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818204  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
LRR_8 pfam13855
Leucine rich repeat;
321-383 7.57e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 7.57e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818204  321 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 3.12e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.76  E-value: 3.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 308818204   103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 312-482 3.26e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 312 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 390
Cdd:cd21340   36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 391 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 464
Cdd:cd21340   92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                        170
                 ....*....|....*...
gi 308818204 465 IEELYLENNQIEEITEIC 482
Cdd:cd21340  144 LEQLDASNNQISDLEELL 161
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-651 4.92e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 4.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 308818204 608 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 651
Cdd:COG4886  321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
315-660 4.79e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 4.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 315 IPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTL 394
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 395 EELKvNENNLQAIDEESLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGKNKFRIIPQGLPG--SIEELYLEN 472
Cdd:COG4886   93 GDLT-NLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 473 NQIEEITEICFNHTrKINVIVLRYNKIEEnriAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIP 550
Cdd:COG4886  169 NQLTDLPEELGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 551 GyvFGHMePGLEYLYLSFNKLADdgmdrVSFYGAYHSLRELFLDHNDLKSIppgiqEMKALHFLRLNNNKIRNILPEEIC 630
Cdd:COG4886  245 E--LGNL-TNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLL 311

                        330       340       350
                 ....*....|....*....|....*....|
gi 308818204 631 NAEEDDDSNLEHLHLENNYIKIREIPSYTF 660
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-602 4.15e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 4.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 303 RTISCINAMLTQIPPLTA--PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITSsgIgPKAFKLLKKLMRLNMDG 380
Cdd:COG4886  116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--L-PEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 381 NNLIQIPSQL--PSTLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEANvnplAFKPLKSLAYLRLGKNKFRIIP 458
Cdd:COG4886  192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 459 QGLP-GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLL 537
Cdd:COG4886  267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308818204 538 HLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIP 602
Cdd:COG4886  347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-657 1.07e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 350 LDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 429
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 430 EANVNPLAFKPLKSLAYLRLGKNKfriiPQGLPGSIEELYLENNQIEEITEicfnhtrkinvivlrynkieenRIAPLaw 509
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPE----------------------ELANL-- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 510 inqENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIPGyVFGHMePGLEYLYLSFNKLADDGMdrvSFYGAyHS 587
Cdd:COG4886  136 ---TNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPE---PLGNL-TN 206

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 588 LRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNIlpEEICNAeedddSNLEHLHLENNyiKIREIPS 657
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNL-----TNLEELDLSNN--QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
298-550 1.09e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 298 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 376
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 377 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 442
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 443 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 520
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 308818204 521 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
292-549 8.13e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 8.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 292 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEafngLPN-LERLDLSKNNITSSgigPKafKLL 370
Cdd:PRK15370 212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISCL---PE--NLP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 371 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNqlvTLELEGNNLSEAnvnPLAFKPlkSLAYLRLG 450
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSL---PASLPP--ELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 451 KNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhtrkiNVivlrynkieenriaPLAwinqenLESIDLSYNKLyhvpS 530
Cdd:PRK15370 355 KNQITVLPETLPPTITTLDVSRNALTNLPE---------NL--------------PAA------LQIMQASRNNL----V 401

                        250
                 ....*....|....*....
gi 308818204 531 YLPKSLLHLVLLGNQIERI 549
Cdd:PRK15370 402 RLPESLPHFRGEGPQPTRI 420
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 1.05e-14

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.61  E-value: 1.05e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818204  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
371-611 2.29e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 371 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDLNQLvtLELEGNNLSEANVN-PLAFKPL-------- 441
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 442 -------KSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhTRKINVIVLrynKIEENRIAPLAWINQEN 514
Cdd:PRK15370 276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 515 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLD 594
Cdd:PRK15370 348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                        250
                 ....*....|....*..
gi 308818204 595 HNDLKSipPGIQEMKAL 611
Cdd:PRK15370 424 YNPFSE--RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
321-383 7.57e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.39  E-value: 7.57e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818204  321 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 3.12e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.76  E-value: 3.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 308818204   103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
369-629 9.27e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 9.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 369 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEeslsdlnqlvtlELEGNnlseanvnplafkpLKSLaYLR 448
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPE------------NLQGN--------------IKTL-YAN 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 449 lgKNKFRIIPQGLPGSIEELYLENNQIEEITEicfNHTRKINVIVLRYNKieenrIAPLAWINQENLESIDLSYNKLYHV 528
Cdd:PRK15370 229 --SNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNK-----ISCLPENLPEELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 529 PSYLPKSLLHLVLLGNQIERIPGYvfghMEPGLEYLYLSFNKLA-------------DDGMDRVSFYGAY--HSLRELFL 593
Cdd:PRK15370 299 PAHLPSGITHLNVQSNSLTALPET----LPPGLKTLEAGENALTslpaslppelqvlDVSKNQITVLPETlpPTITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 308818204 594 DHNDLKSIPPGIQemKALHFLRLNNNKIRNiLPEEI 629
Cdd:PRK15370 375 SRNALTNLPENLP--AALQIMQASRNNLVR-LPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-645 1.18e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 309 NAMLTQIPP--LTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITssGIGPKAFKLLKKLMRLNMDGNNLI-Q 385
Cdd:PLN00113 270 NKLSGPIPPsiFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTSLPRLQVLQLWSNKFSgE 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 386 IPSQL--PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLsEANVnPLAFKPLKSLAYLRLGKNKFRiipQGLPG 463
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL-EGEI-PKSLGACRSLRRVRLQDNSFS---GELPS 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 464 SIEELYLennqieeiteicfnhtrkINVIVLRYNKIEeNRIAPLAWiNQENLESIDLSYNKLY-HVP-SYLPKSLLHLVL 541
Cdd:PLN00113 423 EFTKLPL------------------VYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFgGLPdSFGSKRLENLDL 482

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 542 LGNQIERIPGYVFGHMePGLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SIPPGIQEMKALHFLRLNNNK 620
Cdd:PLN00113 483 SRNQFSGAVPRKLGSL-SELMQLKLSENKLSGEIPDELS---SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQ 558

                        330       340
                 ....*....|....*....|....*
gi 308818204 621 IRNILPEEICNAEEDDDSNLEHLHL 645
Cdd:PLN00113 559 LSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-648 1.57e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 322 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNItSSGIGPKAFKLLKKLMRLNMDGNNLI-QIPSQLPSTLEELKVN 400
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 401 ENNLQAIDEESLSDLNQLVTLELEGNNLSeaNVNPLAFKPLKSLAYLRLGKNKFriiPQGLPGSIEELylennqieeite 480
Cdd:PLN00113 149 NNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------ 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 481 icfnhtRKINVIVLRYNKIE---ENRIAPLAWINQenlesIDLSYNKLyhvPSYLPKSLLHLvllgnqieripgyvfghm 557
Cdd:PLN00113 212 ------KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNL---TGPIPSSLGNL------------------ 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 558 ePGLEYLYLSFNKLADdgmdrvsfygayhslrelfldhndlkSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEeddd 637
Cdd:PLN00113 260 -KNLQYLFLYQNKLSG--------------------------PIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQ---- 308

                        330
                 ....*....|.
gi 308818204 638 sNLEHLHLENN 648
Cdd:PLN00113 309 -NLEILHLFSN 318
LRR_8 pfam13855
Leucine rich repeat;
345-428 2.02e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204  345 PNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMdgnnliqipsqlpstleelkvNENNLQAIDEESLSDLNQLVTLELE 424
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDL---------------------SNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 308818204  425 GNNL 428
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
290-550 2.62e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.56  E-value: 2.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 290 GTLRLPSGCSLSYRTISCINAMLTQIPPLtAPQITSLELTGNSIASIPDEAfnglPNLERLDLSKNNITSSGIGPKAfkl 369
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPAL-PPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG--- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 370 lkkLMRLNMDGNNLIQIPSqLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANVNPlafkplKSLAYLR 448
Cdd:PRK15387 284 ---LCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLA-----SLPALpSELCKLWAYNNQLTSLPTLP------SGLQELS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 449 LGKNKFRIIPQgLPGSIEELYLENNQIEEITEICFNHTRKInvivlrynkIEENRIAPLAWINQEnLESIDLSYNKLYHV 528
Cdd:PRK15387 349 VSDNQLASLPT-LPSELYKLWAYNNRLTSLPALPSGLKELI---------VSGNRLTSLPVLPSE-LKELMVSGNRLTSL 417

                        250       260
                 ....*....|....*....|..
gi 308818204 529 PsYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15387 418 P-MLPSGLLSLSVYRNQLTRLP 438
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 312-482 3.26e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 312 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 390
Cdd:cd21340   36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 391 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 464
Cdd:cd21340   92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                        170
                 ....*....|....*...
gi 308818204 465 IEELYLENNQIEEITEIC 482
Cdd:cd21340  144 LEQLDASNNQISDLEELL 161
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 321-525 7.75e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 7.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 321 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNNL-----IQIPSQ 389
Cdd:COG5238  208 TTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIgaegaIALAKA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 390 L--PSTLEELKVNENNLQaiDE------ESLSDLNQLVTLELEGNNLSEANVNPL--AFKPLKSLAYLRLGKNKfrIIPQ 459
Cdd:COG5238  288 LqgNTTLTSLDLSVNRIG--DEgaialaEGLQGNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLDLSDNQ--IGDE 363

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308818204 460 GLPGSIEelYLENNQieeiteicfnHTRKINvivLRYNKI-EENRIAPLAWINQENLESIDLSYNKL 525
Cdd:COG5238  364 GAIALAK--YLEGNT----------TLRELN---LGKNNIgKQGAEALIDALQTNRLHTLILDGNLI 415
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
376-657 4.76e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 4.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 376 LNMDGNNLIQIPSQLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANV------------NPLAFKPL- 441
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT-----SLPALpPELRTLEVSGNQLTSLPVlppgllelsifsNPLTHLPAl 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 442 -KSLAYLRLGKNKFRIIPQgLPGSIEELYLENNQIEEI----TEICfnhtrkinvIVLRYNkieeNRIAPLAWInQENLE 516
Cdd:PRK15387 281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLpalpSELC---------KLWAYN----NQLTSLPTL-PSGLQ 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 517 SIDLSYNKLYHVPSyLPKSLLHLVLLGNQIERIPGyvfghMEPGLEYLYLSFNKLaddgmdrVSFYGAYHSLRELFLDHN 596
Cdd:PRK15387 346 ELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRL-------TSLPVLPSELKELMVSGN 412

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308818204 597 DLKSIPPGIQEMKALHFLRlnNNKIRniLPEEICNAEEDDDSNLEHLHLENNYIK-IREIPS 657
Cdd:PRK15387 413 RLTSLPMLPSGLLSLSVYR--NQLTR--LPESLIHLSSETTVNLEGNPLSERTLQaLREITS 470
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
294-433 1.56e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 294 LPSGCSlsyrTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAfngLPNLERLDLSKNNITssgIGPKAfkLLKKL 373
Cdd:PRK15370 302 LPSGIT----HLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQIT---VLPET--LPPTI 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818204 374 MRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDE---ESLSDLNQLVTLELEGNNLSEANV 433
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPEslpHFRGEGPQPTRIIVEYNPFSERTI 432
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 312-651 1.88e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.03  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 312 LTQIPPLTAPQITSLEltGNSIASIPDEAFNGLPNLERldlSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQlp 391
Cdd:COG5238   15 LLSANPATTEQSELTK--RATIVNLRSYHLHGGAILLA---RYLQSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPT-- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 392 stlEELKVNENNLQAIDEESLSDLNQLVT-----LELEGNNLSEANVNPLA-----------FKPLKSLAYLRLGKNKFR 455
Cdd:COG5238   88 ---QLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLLGLAAR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 456 I--------IPQGLPGSIEELYLENNQIEE--ITEICfNHTRK---INVIVLRYNKIEENRIAPLAWINQEN--LESIDL 520
Cdd:COG5238  165 LgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksLTTLDL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 521 SYNK-----LYHVPSYL--PKSLLHLVLLGNQIEripgyvfghmEPGLEYL--YLSFNKladdgmdrvsfygayhSLREL 591
Cdd:COG5238  244 SNNQigdegVIALAEALknNTTVETLYLSGNQIG----------AEGAIALakALQGNT----------------TLTSL 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308818204 592 FLDHNDL-----KSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEdDDSNLEHLHLENNYIK 651
Cdd:COG5238  298 DLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 468-650 7.96e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 468 LYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESidlsynklyhvpsyLPKsLLHLVLLGNQIE 547
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KI--------ENLEF--------------LTN-LTHLYLQNNQIE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 548 RIPGyvFGHMePGLEYLYLSFNKLAddgmdRVSFYGAYHSLRELFLDHNDLksiPPGiQEM-----------KALHFLRL 616
Cdd:cd21340   60 KIEN--LENL-VNLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQRL---PPG-EKLtfdprslaalsNSLRVLNI 127

                        170       180       190
                 ....*....|....*....|....*....|....
gi 308818204 617 NNNKIRNILPEEICnaeedddSNLEHLHLENNYI 650
Cdd:cd21340  128 SGNNIDSLEPLAPL-------RNLEQLDASNNQI 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
294-436 3.14e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 294 LPSGcslsYRTISCINAMLTQIPPLTApQITSLELTGNSIASIPdeafnGLPN-LERLDLSKNNITSSGIGPKAfklLKK 372
Cdd:PRK15387 340 LPSG----LQELSVSDNQLASLPTLPS-ELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPVLPSE---LKE 406

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818204 373 LMrlnMDGNNLIQIPsQLPSTLEELKVNENNLQAIdEESLSDLNQLVTLELEGNNLSEANVNPL 436
Cdd:PRK15387 407 LM---VSGNRLTSLP-MLPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQAL 465
LRR_8 pfam13855
Leucine rich repeat;
514-571 3.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308818204  514 NLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFGHMePGLEYLYLSFNKL 571
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
392-454 4.83e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.83e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818204  392 STLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEanVNPLAFKPLKSLAYLRLGKNKF 454
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
535-598 5.77e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818204  535 SLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLadDGMDRVSFYGaYHSLRELFLDHNDL 598
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLL--TTLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 296-525 6.22e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 6.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 296 SGCSLSYRTISCINAMLTQIPPLTapqitSLELTGNSIASIPD------EAFNGLPNLERLDLSKNNITSSGIGPkaFKL 369
Cdd:cd00116   31 EGNTLGEEAAKALASALRPQPSLK-----ELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGV--LES 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 370 LkklmrlnmdgnnliqipsQLPSTLEELKVNENNLQ----AIDEESLSDLN-QLVTLELEGNNLSEANVNPLA--FKPLK 442
Cdd:cd00116  104 L------------------LRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 443 SLAYLRLGKNK-----FRIIPQGLPGS--IEELYLENNQIEE----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWIN 511
Cdd:cd00116  166 DLKELNLANNGigdagIRALAEGLKANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245

                        250
                 ....*....|....*..
gi 308818204 512 QEN---LESIDLSYNKL 525
Cdd:cd00116  246 LSPnisLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 470-672 6.50e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 470 LENNQIEEITEICFNHTRKINVIVlrynkieenRIAPLAWINQENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL-- 541
Cdd:cd00116   47 LRPQPSLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnn 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 542 --LGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS-FYGAYHSLRELFLDHNDLKsiPPGI----QEMKA---L 611
Cdd:cd00116  118 ngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAkALRANRDLKELNLANNGIG--DAGIralaEGLKAncnL 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308818204 612 HFLRLNNNKIRNILPEEICNAEEDDDSnLEHLHLENNyiKIREIPSYTFSCIRSYSSIVLK 672
Cdd:cd00116  196 EVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN--NLTDAGAAALASALLSPNISLL 253
LRR_8 pfam13855
Leucine rich repeat;
559-621 2.15e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.15e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818204  559 PGLEYLYLSFNKLadDGMDRVSFYGAyHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKI 621
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
464-525 3.73e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308818204  464 SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKL 525
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 320-623 4.23e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 4.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 320 APQITSLELTGNSI-----ASIPDEAFNGLPNLERLDLSKNNITSSGIgpkafKLLKKLMRLNmdgnnliqipsqlpSTL 394
Cdd:COG5238  150 PLGGNAVHLLGLAArlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQN--------------TTV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 395 EELKVNENNlqaIDEES-------LSDLNQLVTLELEGNNLSEANVNPLAfkplkslAYLRLGKNkfriipqglpgsIEE 467
Cdd:COG5238  211 TTLWLKRNP---IGDEGaeilaeaLKGNKSLTTLDLSNNQIGDEGVIALA-------EALKNNTT------------VET 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 468 LYLENNQIEEITEICFNHTRKINvIVLRYNKIEENRIAPLAWIN-----QEN--LESIDLSYNKLyhvpsylpksllhlv 540
Cdd:COG5238  269 LYLSGNQIGAEGAIALAKALQGN-TTLTSLDLSVNRIGDEGAIAlaeglQGNktLHTLNLAYNGI--------------- 332

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 541 llGNQ-IERIPGYVFGHmePGLEYLYLSFNKLADDGMDRVSFYGAYH-SLRELFLDHNDL-----KSIPPGIQEMKaLHF 613
Cdd:COG5238  333 --GAQgAIALAKALQEN--TTLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNIgkqgaEALIDALQTNR-LHT 407

                        330
                 ....*....|
gi 308818204 614 LRLNNNKIRN 623
Cdd:COG5238  408 LILDGNLIGA 417
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 320-454 1.57e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 320 APQITSLELTGNSIASIPDE----AFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNN--------LIQ 385
Cdd:cd00116  136 PPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNGltdegasaLAE 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308818204 386 IPSQLPStLEELKVNENNL-----QAIDEESLSDLNQLVTLELEGNNLSEANVNPLA--FKPLKSLAYLRLGKNKF 454
Cdd:cd00116  216 TLASLKS-LEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevLAEKESLLELDLRGNKF 290
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
103-143 2.26e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 39.85  E-value: 2.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 308818204   103 CLVKGITMYNKAVWSpEPCTTCLCSDGRVLCDETMCHPQRC 143
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC 40
LRR_8 pfam13855
Leucine rich repeat;
587-650 3.24e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308818204  587 SLRELFLDHNDLKSIPPGI-QEMKALHFLRLNNNKIRNILPEEIcnaeeDDDSNLEHLHLENNYI 650
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAF-----SGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 441-654 1.22e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 441 LKSLAYLRL-GKNKFRIIPQGLPGSIEELYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESId 519
Cdd:cd21340    1 LKRITHLYLnDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--KI--------ENLENL- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 520 lsynklyhvpsylpKSLLHLVLLGNQIERIPGyvfghME--PGLEYLYLSFNKLADDGM---DRVSFYGAYHSLRELFLD 594
Cdd:cd21340   68 --------------VNLKKLYLGGNRISVVEG-----LEnlTNLEELHIENQRLPPGEKltfDPRSLAALSNSLRVLNIS 128

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818204 595 HNDLKSIPPgIQEMKALHFLRLNNNKIRNIlpEEICNAEEdDDSNLEHLHLENNYI----KIRE 654
Cdd:cd21340  129 GNNIDSLEP-LAPLRNLEQLDASNNQISDL--EELLDLLS-SWPSLRELDLTGNPVckkpKYRD 188
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 394-621 1.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 394 LEELKVNENNLqaiDEESLSDL-------NQLVTLELEGNNLSEANVN----PLAFKPLKSLAYLRLGKNKFRIIPQGL- 461
Cdd:cd00116   25 LQVLRLEGNTL---GEEAAKALasalrpqPSLKELCLSLNETGRIPRGlqslLQGLTKGCGLQELDLSDNALGPDGCGVl 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 462 -----PGSIEELYLENNQIEE-----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN--LESIDLSYNKLYH-- 527
Cdd:cd00116  102 esllrSSSLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANrdLKELNLANNGIGDag 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 528 VPSYLP-----KSLLHLVLLGNQIERIPGYVFGHM---EPGLEYLYLSFNKLADDGMDRV--SFYGAYHSLRELFLDHND 597
Cdd:cd00116  182 IRALAEglkanCNLEVLDLNNNGLTDEGASALAETlasLKSLEVLNLGDNNLTDAGAAALasALLSPNISLLTLSLSCND 261

                        250       260
                 ....*....|....*....|....*....
gi 308818204 598 L-----KSIPPGIQEMKALHFLRLNNNKI 621
Cdd:cd00116  262 ItddgaKDLAEVLAEKESLLELDLRGNKF 290
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 321-360 1.58e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308818204  321 PQITSLELTGNSIASIPdeAFNGLPNLERLDLSKNNITSS 360
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 321-398 1.74e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 321 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGigpkAFKLLK-----KLMRLNMDGNNL-IQIPSQL 390
Cdd:COG5238  348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQG----AEALIDalqtnRLHTLILDGNLIgAEAQQRL 423


                 ....*...
gi 308818204 391 PSTLEELK 398
Cdd:COG5238  424 EQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 339-431 2.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 339 EAFNGLPNLERLDLSKNNITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIP-----SQLPS---TLEELKVNENNLQAID 408
Cdd:cd00116  187 EGLKANCNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSpniSLLTLSLSCNDITDDG 266

                         90       100
                 ....*....|....*....|....*..
gi 308818204 409 EESLS----DLNQLVTLELEGNNLSEA 431
Cdd:cd00116  267 AKDLAevlaEKESLLELDLRGNKFGEE 293
PLN03150 PLN03150
hypothetical protein; Provisional
 325-394 3.66e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204 325 SLELTGNSIASIPDEAFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLiqiPSQLPSTL 394
Cdd:PLN03150 446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF--NGSIPESLGQLTSLRILNLNGNSL---SGRVPAAL 510
IGFBP pfam00219
Insulin-like growth factor binding protein;
133-161 4.89e-03

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 35.76  E-value: 4.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 308818204  133 CDETMC--HPQRCPQTVIPEG-ECCPVCSATE 161
Cdd:pfam00219   5 CDPERCppPPPGCPAGVVLDGcGCCKVCARQE 36
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 345-392 5.16e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 308818204  345 PNLERLDLSKNNITSSGigpkAFKLLKKLMRLNMDGNNLIQIPSQLPS 392
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKITDLSDLAN 44
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-189 7.23e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 39.29  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818204  116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSAT----------EQREPTNLLHKQLPP 175
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIvsldysscfdLQTYRARLRHLFLAL 263

                          90
                  ....*....|....*....
gi 308818204  176 P-----QVGMDRIVRKEAL 189
Cdd:pfam14828 264 PkykgvQLAVSKVGKDQRL 282
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 587-624 7.97e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 7.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 308818204  587 SLRELFLDHNDLKSIPPgIQEMKALHFLRL-NNNKIRNI 624
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLsGNNKITDL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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