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Conserved domains on  [gi|310923122|ref|NP_001185610|]
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leptin receptor gene-related protein isoform 2 [Homo sapiens]

Protein Classification

Vps55 family protein( domain architecture ID 10514166)

Vps55 family protein such as vacuolar protein sorting-associated protein 55 (Vps55) from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals; both proteins are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells

Gene Ontology:  GO:0032511|GO:0005768

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 16-133 8.95e-35

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


:

Pssm-ID: 461188  Cd Length: 118  Bit Score: 116.84  E-value: 8.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923122   16 LVALSFSGAIGLTFLMLGCALedYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATS--SACRELAYFFTTGIVVSAFGF 93
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCAL--YKNWWPLLVVLFYVLAPLPNLIASRSSSSSDDSSsgSAWVDFGRFLTGFLVVSGIAL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 310923122   94 PVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGD 133
Cdd:pfam04133  79 PIVLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 16-133 8.95e-35

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


Pssm-ID: 461188  Cd Length: 118  Bit Score: 116.84  E-value: 8.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923122   16 LVALSFSGAIGLTFLMLGCALedYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATS--SACRELAYFFTTGIVVSAFGF 93
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCAL--YKNWWPLLVVLFYVLAPLPNLIASRSSSSSDDSSsgSAWVDFGRFLTGFLVVSGIAL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 310923122   94 PVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGD 133
Cdd:pfam04133  79 PIVLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 16-133 8.95e-35

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


Pssm-ID: 461188  Cd Length: 118  Bit Score: 116.84  E-value: 8.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923122   16 LVALSFSGAIGLTFLMLGCALedYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATS--SACRELAYFFTTGIVVSAFGF 93
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCAL--YKNWWPLLVVLFYVLAPLPNLIASRSSSSSDDSSsgSAWVDFGRFLTGFLVVSGIAL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 310923122   94 PVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGD 133
Cdd:pfam04133  79 PIVLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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