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Conserved domains on  [gi|311771647|ref|NP_001185709|]
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actin-related protein 2/3 complex subunit 4 isoform c [Homo sapiens]

Protein Classification

actin-related protein 2/3 complex subunit 4 family protein( domain architecture ID 10530811)

actin-related protein 2/3 complex subunit 4 family protein; similar to human actin-related protein 2/3 complex subunit 4 (ARPC4) which is as an actin-binding component of the Arp2/3 complex which controls actin polymerization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARPC4 pfam05856
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 21-185 1.55e-107

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


:

Pssm-ID: 461760  Cd Length: 166  Bit Score: 304.52  E-value: 1.55e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647   21 TATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADE 100
Cdd:pfam05856   2 SSTLRPYLDAVRSTLNAALCLQNFPSQVVERHNKPEVEVKSSPELLLNPLIISRNEKEKCLIESSINSVRVSIKIKQADE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  101 IEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVA 180
Cdd:pfam05856  82 IERILAQKFTRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVA 161


                  ....*
gi 311771647  181 EEFLK 185
Cdd:pfam05856 162 EEYLA 166
 
Name Accession Description Interval E-value
ARPC4 pfam05856
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 21-185 1.55e-107

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


Pssm-ID: 461760  Cd Length: 166  Bit Score: 304.52  E-value: 1.55e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647   21 TATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADE 100
Cdd:pfam05856   2 SSTLRPYLDAVRSTLNAALCLQNFPSQVVERHNKPEVEVKSSPELLLNPLIISRNEKEKCLIESSINSVRVSIKIKQADE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  101 IEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVA 180
Cdd:pfam05856  82 IERILAQKFTRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVA 161


                  ....*
gi 311771647  181 EEFLK 185
Cdd:pfam05856 162 EEYLA 166
PTZ00278 PTZ00278
ARP2/3 complex subunit; Provisional
 21-187 5.19e-89

ARP2/3 complex subunit; Provisional


Pssm-ID: 240342  Cd Length: 174  Bit Score: 258.13  E-value: 5.19e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  21 TATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEV----RSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVK 96
Cdd:PTZ00278   2 ATTYQPYYDCIRKTLEAALCLGNFPSQIIERHNKPEVELngyeGKSKELVLNPIYIVRSEKEKCLIEPSINSVRISFSFK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  97 QADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARA 176
Cdd:PTZ00278  82 KSDELDVIIARKFVSFLAQRAEQFVILRRKPIPGYDISFLITNFHTENMFKHKLIDFIIDFMEDIDKDISDMKLNVNTRA 161

                        170
                 ....*....|.
gi 311771647 177 RIVAEEFLKNF 187
Cdd:PTZ00278 162 RIAAPEFFKAL 172
 
Name Accession Description Interval E-value
ARPC4 pfam05856
ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 ...
 21-185 1.55e-107

ARP2/3 complex 20 kDa subunit (ARPC4); This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.


Pssm-ID: 461760  Cd Length: 166  Bit Score: 304.52  E-value: 1.55e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647   21 TATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADE 100
Cdd:pfam05856   2 SSTLRPYLDAVRSTLNAALCLQNFPSQVVERHNKPEVEVKSSPELLLNPLIISRNEKEKCLIESSINSVRVSIKIKQADE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  101 IEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVA 180
Cdd:pfam05856  82 IERILAQKFTRFLMQRAEAFIILRRKPVEGYDISFLITNHHTEQMGKHKLIDFIITFMEEIDKEISEMKLSLNARARIVA 161


                  ....*
gi 311771647  181 EEFLK 185
Cdd:pfam05856 162 EEYLA 166
PTZ00278 PTZ00278
ARP2/3 complex subunit; Provisional
 21-187 5.19e-89

ARP2/3 complex subunit; Provisional


Pssm-ID: 240342  Cd Length: 174  Bit Score: 258.13  E-value: 5.19e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  21 TATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEV----RSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVK 96
Cdd:PTZ00278   2 ATTYQPYYDCIRKTLEAALCLGNFPSQIIERHNKPEVELngyeGKSKELVLNPIYIVRSEKEKCLIEPSINSVRISFSFK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311771647  97 QADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARA 176
Cdd:PTZ00278  82 KSDELDVIIARKFVSFLAQRAEQFVILRRKPIPGYDISFLITNFHTENMFKHKLIDFIIDFMEDIDKDISDMKLNVNTRA 161

                        170
                 ....*....|.
gi 311771647 177 RIVAEEFLKNF 187
Cdd:PTZ00278 162 RIAAPEFFKAL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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