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Conserved domains on  [gi|342672050|ref|NP_001185903|]
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TMEM110-MUSTN1 fusion protein [Homo sapiens]

Protein Classification

STIMATE family protein( domain architecture ID 11193466)

STIMATE family protein similar to human store-operated calcium entry regulator STIMATE, also called transmembrane protein 110 (TMEM110), a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 1.81e-53

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


:

Pssm-ID: 463561  Cd Length: 124  Bit Score: 172.67  E-value: 1.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672050  100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 342672050  179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
Mustang pfam15682
Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of ...
 298-372 3.73e-44

Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of short, approx 80 residue, proteins found in chordates. It localizes to the nucleus and specifically, spatially in mesenchymal cells of the developing limbs and tail as well as in the fracture callus, especially in periosteal osteoprogenitor cells, proliferating chondrocytes, and young active osteoblasts. It is highly expressed during embryogenesis and inactivated in most adult tissues with the exception of skeletal muscle and tendon where is is acutely and differentially expressed during bone regeneration.


:

Pssm-ID: 464800  Cd Length: 75  Bit Score: 147.00  E-value: 3.73e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342672050  298 EAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG 372
Cdd:pfam15682   1 AAVIKKKRPPVKEEDLKGARSKLGSKQEVKSKTYQVMVECEQAGSAAPSVFSRDRTGTETVFDKPKAGPPKSVFG 75
 
Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 1.81e-53

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


Pssm-ID: 463561  Cd Length: 124  Bit Score: 172.67  E-value: 1.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672050  100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 342672050  179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
Mustang pfam15682
Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of ...
 298-372 3.73e-44

Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of short, approx 80 residue, proteins found in chordates. It localizes to the nucleus and specifically, spatially in mesenchymal cells of the developing limbs and tail as well as in the fracture callus, especially in periosteal osteoprogenitor cells, proliferating chondrocytes, and young active osteoblasts. It is highly expressed during embryogenesis and inactivated in most adult tissues with the exception of skeletal muscle and tendon where is is acutely and differentially expressed during bone regeneration.


Pssm-ID: 464800  Cd Length: 75  Bit Score: 147.00  E-value: 3.73e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342672050  298 EAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG 372
Cdd:pfam15682   1 AAVIKKKRPPVKEEDLKGARSKLGSKQEVKSKTYQVMVECEQAGSAAPSVFSRDRTGTETVFDKPKAGPPKSVFG 75
 
Name Accession Description Interval E-value
STIMATE pfam12400
STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive ...
 100-219 1.81e-53

STIMATE family; STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.


Pssm-ID: 463561  Cd Length: 124  Bit Score: 172.67  E-value: 1.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672050  100 CSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLIL-QW 178
Cdd:pfam12400   1 CSWYFLNILLDTTLGVLILYLLLRLLTKLARRKGIEGIESGNYGKPPSFRAWLKQLLVYLLGLVIMKLVVFLLLLLFpWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 342672050  179 KKVA--LLNPIE-NPDLKLAIVMLIVPFFVNALMFWVVDNFLMR 219
Cdd:pfam12400  81 FWVGdwLLSWLDgNPKLQLIFVMLIFPLIMNALQFWIIDSIIKK 124
Mustang pfam15682
Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of ...
 298-372 3.73e-44

Musculoskeletal, temporally activated-embryonic nuclear protein 1; Mustang is a family of short, approx 80 residue, proteins found in chordates. It localizes to the nucleus and specifically, spatially in mesenchymal cells of the developing limbs and tail as well as in the fracture callus, especially in periosteal osteoprogenitor cells, proliferating chondrocytes, and young active osteoblasts. It is highly expressed during embryogenesis and inactivated in most adult tissues with the exception of skeletal muscle and tendon where is is acutely and differentially expressed during bone regeneration.


Pssm-ID: 464800  Cd Length: 75  Bit Score: 147.00  E-value: 3.73e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342672050  298 EAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG 372
Cdd:pfam15682   1 AAVIKKKRPPVKEEDLKGARSKLGSKQEVKSKTYQVMVECEQAGSAAPSVFSRDRTGTETVFDKPKAGPPKSVFG 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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