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Conserved domains on  [gi|312222719|ref|NP_001185947|]
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leucine-rich repeat-containing protein 49 isoform 3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-269 2.59e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 143.77  E-value: 2.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  73 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 152
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 153 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 224
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222719 225 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 269
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-269 2.59e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.77  E-value: 2.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  73 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 152
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 153 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 224
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222719 225 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 269
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-237 1.48e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  24 INLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIE 103
Cdd:COG4886   47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 104 EI-SGLSTLRCLRVLLLGKNRIKKI-SNLENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLDS 179
Cdd:COG4886  127 DLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTN 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312222719 180 LTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVSCLadsSSLSDITFDGNPI 237
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEELDLSNNQL 262
LRR_9 pfam14580
Leucine-rich repeat;
139-270 8.67e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.24  E-value: 8.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  139 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 215
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 312222719  216 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 270
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-269 2.59e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.77  E-value: 2.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  73 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 152
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 153 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 224
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222719 225 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 269
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-237 1.48e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  24 INLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIE 103
Cdd:COG4886   47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 104 EI-SGLSTLRCLRVLLLGKNRIKKI-SNLENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLDS 179
Cdd:COG4886  127 DLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTN 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312222719 180 LTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVSCLadsSSLSDITFDGNPI 237
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-258 7.72e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 7.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  20 SGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYD 99
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 100 NQIEEISGLSTLRCLRVLLLGKNriKKISNLENLKSldvLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGL 177
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGN--EELSNLTNLES---LDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 178 DSLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVscLADSSSLSDITFDGNPIAQESwykhTVLQNMMQLRQ 256
Cdd:COG4886  159 TNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLP----EPLANLTNLET 232


                 ..
gi 312222719 257 LD 258
Cdd:COG4886  233 LD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-217 1.35e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  70 LRLLNFQHNFITRI-QNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 148
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312222719 149 IeNINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDS 217
Cdd:COG4886  287 L-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR_9 pfam14580
Leucine-rich repeat;
139-270 8.67e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.24  E-value: 8.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  139 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 215
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 312222719  216 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 270
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_8 pfam13855
Leucine rich repeat;
157-212 5.78e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  157 ELRVLNLARNFLSHVD--NLNGLDSLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNI 212
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-250 8.26e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 8.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  69 HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIK--KISNLENLKSLDVLDLHGNQI 146
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 147 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSS 226
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170       180
                 ....*....|....*....|....
gi 312222719 227 LSDITFDGNPIAQESWYKHTVLQN 250
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-259 1.91e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  72 LLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIEN 151
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 152 INHLCELRVLNLARNflshvDNLNGLDSLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVscLADSSSLSDI 230
Cdd:COG4886   92 LGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSL 164

                        170       180
                 ....*....|....*....|....*....
gi 312222719 231 TFDGNPIAQESwykhTVLQNMMQLRQLDM 259
Cdd:COG4886  165 DLSNNQLTDLP----EELGNLTNLKELDL 189
LRR_8 pfam13855
Leucine rich repeat;
135-190 6.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 6.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  135 SLDVLDLHGNQITKI--ENINHLCELRVLNLARNFLSHVDN--LNGLDSLTELNLRHNQI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 114-154 1.38e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.62  E-value: 1.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 312222719  114 LRVLLLGKNRIKKISNLENLKSLDVLDLHGN-QITKIENINH 154
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-230 3.40e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  50 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEIS--GLSTLRCLRVLLLGKNRIKKI 127
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlkELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 128 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFL 207
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        170       180
                 ....*....|....*....|...
gi 312222719 208 SFNNISSFDSVSCLADSSSLSDI 230
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-149 1.13e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  70 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLrclrvlllgknrikkisnLENLKSLDVLDLHGNQITKI 149
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDL------------------LSSWPSLRELDLTGNPVCKK 183
LRR_8 pfam13855
Leucine rich repeat;
179-237 1.36e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312222719  179 SLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNISSFDSVScLADSSSLSDITFDGNPI 237
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 94-191 1.49e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  94 SLDLYDNQIEE------ISGLSTLRCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IENINHL 155
Cdd:COG5238  268 TLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqgaialAKALQEN 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 312222719 156 CELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQIT 191
Cdd:COG5238  348 TTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIG 389
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 90-132 1.65e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 312222719   90 QKLISLDLYDNQIEEISGLSTLRCLRVL-LLGKNRIKKISNLEN 132
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-179 1.70e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 312222719  134 KSLDVLDLHGNQITKIENINHLCELRVLNLARNFLshVDNLNGLDS 179
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-213 6.99e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 6.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  91 KLISLDLYDNQI-----EEISG-LSTLRCLRVLLLGKN--------RIKKIsnLENLKSLDVLDLHGNQITKI------E 150
Cdd:cd00116  138 ALEKLVLGRNRLegascEALAKaLRANRDLKELNLANNgigdagirALAEG--LKANCNLEVLDLNNNGLTDEgasalaE 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222719 151 NINHLCELRVLNLARNFLSHVD-------NLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNIS 213
Cdd:cd00116  216 TLASLKSLEVLNLGDNNLTDAGaaalasaLLSPNISLLTLSLSCNDITddgakdLAEVLAEKESLLELDLRGNKFG 291
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 179-211 1.11e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 312222719  179 SLTELNLRHNQITFVRDVDNLPCLQHLFLSFNN 211
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 69-109 1.83e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 312222719   69 HLRLLNFQHNFITRIQNISNLQKLISLDLYDN-QIEEISGLS 109
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 83-240 2.19e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  83 IQNISNLQKLISLDLYDNQI--EEISGLSTL----RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK-- 148
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIgdEGVIALAEAlknnTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDeg 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719 149 ----IENINHLCELRVLNLARNFLSHV------DNLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNI 212
Cdd:COG5238  309 aialAEGLQGNKTLHTLNLAYNGIGAQgaialaKALQENTTLHSLDLSDNQIGdegaiaLAKYLEGNTTLRELNLGKNNI 388

                        170       180       190
                 ....*....|....*....|....*....|.
gi 312222719 213 SSfDSVSCLADSS---SLSDITFDGNPIAQE 240
Cdd:COG5238  389 GK-QGAEALIDALqtnRLHTLILDGNLIGAE 418
LRR_8 pfam13855
Leucine rich repeat;
69-124 2.42e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719   69 HLRLLNFQHNFITRI--QNISNLQKLISLDLYDNQIEEISG--LSTLRCLRVLLLGKNRI 124
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 158-200 6.98e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 312222719  158 LRVLNLARNFLSHVDNLNGLDSLTELNLRHNqiTFVRDVDNLP 200
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 90-213 7.04e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222719  90 QKLISLDLYDNQIEEiSGLSTL-------RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IE 150
Cdd:COG5238  180 NSVETVYLGCNQIGD-EGIEELaealtqnTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGDegvialAE 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312222719 151 NINHLCELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH------LFLSFNNIS 213
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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