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Conserved domains on  [gi|312596914|ref|NP_001186104|]
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target of rapamycin complex subunit LST8 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-319 6.83e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 6.83e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 87
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 167 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596914 247 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 319
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-319 6.83e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 6.83e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 87
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 167 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596914 247 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 319
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-296 1.51e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 1.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 91
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 170
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596914 251 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 296
Cdd:cd00200  251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-246 8.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 8.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 312596914   211 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-113 1.22e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEVTPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVNKN 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSKT 663

                         90       100
                 ....*....|....*....|....*..
gi 312596914  87 IASVGFhEDGRWMYTGGEDCTARIWDL 113
Cdd:PLN00181 664 VSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
211-246 3.84e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 312596914  211 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-319 6.83e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 6.83e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 87
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 166
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 167 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596914 247 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 319
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-296 3.78e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 3.78e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 91
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKL--LRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 170
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596914 251 FSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 296
Cdd:COG2319  362 GELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-296 1.51e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 1.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 91
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 170
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596914 251 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 296
Cdd:cd00200  251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
14-250 1.79e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 1.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  14 ILATAGYDHTVRFWQAHSGICTRTVQ-HQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNIASVG 91
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGtVRLWDLAT--GKLLRTLTGHSGSVRSVA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  92 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 170
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-319 5.15e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 5.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 87
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  88 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 167
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 168 PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 247
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 312596914 248 TSNFSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 319
Cdd:COG2319  233 LATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-247 5.40e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.40  E-value: 5.40e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  15 LATAGYDHTVRFWQAHSGICTRT-VQHQDSVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVGF 92
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKC--LTTLRGHTDWVNSVAF 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  93 HEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS 171
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312596914 172 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtqlIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 247
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
91-320 7.67e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 7.67e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  91 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 170
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 251 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 320
Cdd:COG2319  152 GKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-155 2.89e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914   8 VGSDPVILATAGYDHTVRFWQAHSGICTRT-VQHQDSVNALEVTPD-RSMIAAAGYQHIRMYDLNSnnPNPIISYDGVNK 85
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLST--GKCLGTLRGHEN 220

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  86 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 155
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-322 1.15e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 171 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 250
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 312596914 251 FSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 322
Cdd:cd00200   83 GECVRTL--------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 215-322 4.37e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 4.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914 215 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGnpgessrgWMWGCAFSGDSQYIVTASSDNLAR 294
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRDVAASADGTYLASGSSDKTIR 76

                         90       100
                 ....*....|....*....|....*...
gi 312596914 295 LWCVETGEIKREYGGHQKAVVCLAFNDS 322
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPD 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-246 8.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 8.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 312596914   211 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-113 1.22e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596914  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSVNALEVTPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVNKN 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSKT 663

                         90       100
                 ....*....|....*....|....*..
gi 312596914  87 IASVGFhEDGRWMYTGGEDCTARIWDL 113
Cdd:PLN00181 664 VSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
211-246 3.84e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 312596914  211 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 246
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
75-112 7.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 7.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312596914   75 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 1.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312596914    73 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 112
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-296 5.39e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.39e-03
                           10        20
                   ....*....|....*....|....*...
gi 312596914   269 RGWMWGCAFSGDSQYIVTASSDNLARLW 296
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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