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Conserved domains on  [gi|312922335|ref|NP_001186181|]
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shugoshin 1 isoform EF [Homo sapiens]

Protein Classification

Shugoshin_N and Shugoshin_C domain-containing protein( domain architecture ID 10540877)

Shugoshin_N and Shugoshin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Shugoshin_N pfam07558
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ...
 22-66 1.83e-05

Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.


:

Pssm-ID: 462208  Cd Length: 45  Bit Score: 41.83  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 312922335   22 MKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVL 66
Cdd:pfam07558   1 LKRKYLRQNRELAKSNSALSLKIRELEKEISELLSENLNLRSQVL 45
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 474-495 2.26e-05

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


:

Pssm-ID: 462207  Cd Length: 24  Bit Score: 41.31  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 312922335  474 PKRRCTASVNYKEPTLASKLRR 495
Cdd:pfam07557   3 PSRRARKPVSYKEPSLRSKMRR 24
 
Name Accession Description Interval E-value
Shugoshin_N pfam07558
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ...
 22-66 1.83e-05

Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.


Pssm-ID: 462208  Cd Length: 45  Bit Score: 41.83  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 312922335   22 MKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVL 66
Cdd:pfam07558   1 LKRKYLRQNRELAKSNSALSLKIRELEKEISELLSENLNLRSQVL 45
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 474-495 2.26e-05

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


Pssm-ID: 462207  Cd Length: 24  Bit Score: 41.31  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 312922335  474 PKRRCTASVNYKEPTLASKLRR 495
Cdd:pfam07557   3 PSRRARKPVSYKEPSLRSKMRR 24
 
Name Accession Description Interval E-value
Shugoshin_N pfam07558
Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved ...
 22-66 1.83e-05

Shugoshin N-terminal coiled-coil region; The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.


Pssm-ID: 462208  Cd Length: 45  Bit Score: 41.83  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 312922335   22 MKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVL 66
Cdd:pfam07558   1 LKRKYLRQNRELAKSNSALSLKIRELEKEISELLSENLNLRSQVL 45
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 474-495 2.26e-05

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


Pssm-ID: 462207  Cd Length: 24  Bit Score: 41.31  E-value: 2.26e-05
                          10        20
                  ....*....|....*....|..
gi 312922335  474 PKRRCTASVNYKEPTLASKLRR 495
Cdd:pfam07557   3 PSRRARKPVSYKEPSLRSKMRR 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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