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Conserved domains on  [gi|315434223|ref|NP_001186782|]
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GTP:AMP phosphotransferase AK3, mitochondrial isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK super family cl37624
Adenylate kinase;
1-120 1.32e-62

Adenylate kinase;


The actual alignment was detected with superfamily member pfam00406:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 190.21  E-value: 1.32e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223    1 MTRLALHELKNL-TQYSWLLDGFPRTLPQAEALDR----AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPP 75
Cdd:pfam00406  60 VVGLVKERLEQNdCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPP 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 315434223   76 KTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKK 120
Cdd:pfam00406 140 KVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
1-120 1.32e-62

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 190.21  E-value: 1.32e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223    1 MTRLALHELKNL-TQYSWLLDGFPRTLPQAEALDR----AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPP 75
Cdd:pfam00406  60 VVGLVKERLEQNdCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPP 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 315434223   76 KTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKK 120
Cdd:pfam00406 140 KVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 3-129 1.58e-61

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 188.41  E-value: 1.58e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   3 RLALHELKNltqySWLLDGFPRTLPQAEALDRA-----YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT 77
Cdd:COG0563   71 RLAQPDCAN----GFILDGFPRTVAQAEALDELlaelgIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKV 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 315434223  78 VGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT 129
Cdd:COG0563  147 EGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 17-129 5.54e-59

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 182.27  E-value: 5.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  17 WLLDGFPRTLPQAEALDRAY-----QIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQR 91
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 315434223  92 EDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT 129
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 17-143 1.59e-57

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 178.20  E-value: 1.59e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   17 WLLDGFPRTLPQAEALDR--AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDD 94
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDAllEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 315434223   95 KPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT-ETNKIWPYVYAFLQ 143
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-131 1.28e-47

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 152.78  E-value: 1.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   1 MTRLALHEL-KNLTQYSWLLDGFPRTLPQAEALDRAYQ----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIefnpp 75
Cdd:cd01428   63 VIKLLKERLkKPDCKKGFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL----- 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 315434223  76 ktvGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET 131
Cdd:cd01428  138 ---GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
1-120 1.32e-62

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 190.21  E-value: 1.32e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223    1 MTRLALHELKNL-TQYSWLLDGFPRTLPQAEALDR----AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPP 75
Cdd:pfam00406  60 VVGLVKERLEQNdCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPP 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 315434223   76 KTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKK 120
Cdd:pfam00406 140 KVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 3-129 1.58e-61

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 188.41  E-value: 1.58e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   3 RLALHELKNltqySWLLDGFPRTLPQAEALDRA-----YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT 77
Cdd:COG0563   71 RLAQPDCAN----GFILDGFPRTVAQAEALDELlaelgIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKV 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 315434223  78 VGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT 129
Cdd:COG0563  147 EGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 17-129 5.54e-59

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 182.27  E-value: 5.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  17 WLLDGFPRTLPQAEALDRAY-----QIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQR 91
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 315434223  92 EDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT 129
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 17-143 1.59e-57

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 178.20  E-value: 1.59e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   17 WLLDGFPRTLPQAEALDR--AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDD 94
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDAllEEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 315434223   95 KPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT-ETNKIWPYVYAFLQ 143
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-131 1.28e-47

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 152.78  E-value: 1.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   1 MTRLALHEL-KNLTQYSWLLDGFPRTLPQAEALDRAYQ----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIefnpp 75
Cdd:cd01428   63 VIKLLKERLkKPDCKKGFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL----- 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 315434223  76 ktvGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET 131
Cdd:cd01428  138 ---GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
PLN02674 PLN02674
adenylate kinase
 14-123 5.31e-44

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 145.03  E-value: 5.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  14 QYSWLLDGFPRTLPQAEALD-----RAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPL 88
Cdd:PLN02674 109 QKGFILDGFPRTVVQAQKLDemlakQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPL 188

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 315434223  89 IQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVL 123
Cdd:PLN02674 189 IQRKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVV 223
PRK14530 PRK14530
adenylate kinase; Provisional
 17-135 1.29e-32

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 114.89  E-value: 1.29e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  17 WLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKP 96
Cdd:PRK14530  85 FVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDDDTE 164

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 315434223  97 ETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET-NKIW 135
Cdd:PRK14530 165 ETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVW 204
PRK14526 PRK14526
adenylate kinase; Provisional
 16-119 4.77e-22

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 87.60  E-value: 4.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  16 SWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDK 95
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDK 159

                         90       100
                 ....*....|....*....|....
gi 315434223  96 PETVIKRLKAYEDQTKPVLEYYQK 119
Cdd:PRK14526 160 EESLKTRLQEYKLQTKPLIEFYSK 183
PLN02459 PLN02459
probable adenylate kinase
 18-126 3.77e-19

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 81.05  E-value: 3.77e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  18 LLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNI------EFNPPKTVGIDDLTGEP---- 87
Cdd:PLN02459 113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVadidlkGEDGRPGIVMPPLLPPPecas 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 315434223  88 -LIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETF 126
Cdd:PLN02459 193 kLITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
PRK14532 PRK14532
adenylate kinase; Provisional
 18-128 1.99e-18

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 77.55  E-value: 1.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  18 LLDGFPRTLPQAEALD-----RAYQIDTVINLNVPFEVIKQRLTARWIHPAsgrvyniefnppktvgiddltgepliqRE 92
Cdd:PRK14532  82 IFDGFPRTVAQAEALDkmlasRGQKIDVVIRLKVDDEALIERIVKRFEEQG---------------------------RP 134

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 315434223  93 DDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSG 128
Cdd:PRK14532 135 DDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
adk PRK02496
adenylate kinase; Provisional
 13-131 5.17e-18

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 76.33  E-value: 5.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  13 TQYSWLLDGFPRTLPQAEALDR-----AYQIDTVINLNVPFEVIKQRLTARwihpasgrvyniefnppktvgiddltgep 87
Cdd:PRK02496  78 AANGWILDGFPRKVTQAAFLDEllqeiGQSGERVVNLDVPDDVVVERLLAR----------------------------- 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 315434223  88 liQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET 131
Cdd:PRK02496 129 --GRKDDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PLN02842 PLN02842
nucleotide kinase
 3-117 6.24e-18

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 79.52  E-value: 6.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   3 RLALHELKnltQYSWLLDGFPRTLPQAEALDR-AYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTVGID 81
Cdd:PLN02842  68 RLSREDAK---EKGWLLDGYPRSFAQAQSLEKlKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEIK 144

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 315434223  82 dltgEPLIQREDDKPETVIKRLKAYEDQTKPVLEYY 117
Cdd:PLN02842 145 ----ARLITRPDDTEEKVKARLQIYKKNAEAILSTY 176
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 58-93 8.45e-18

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 71.72  E-value: 8.45e-18
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 315434223   58 RWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQRED 93
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
PRK14531 PRK14531
adenylate kinase; Provisional
 8-125 1.33e-17

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 75.23  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   8 ELKNLTQYSWLLDGFPRTLPQAEALDRAYQ-----IDTVINLNVPFEVIKQRLTARwihpasGRvyniefnppktvgidd 82
Cdd:PRK14531  73 QLKALNSGGWLLDGFPRTVAQAEALEPLLEelkqpIEAVVLLELDDAVLIERLLAR------GR---------------- 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 315434223  83 ltgepliqreDDKPETVIK-RLKAYEDQTKPVLEYYQKKGVLET 125
Cdd:PRK14531 131 ----------ADDNEAVIRnRLEVYREKTAPLIDHYRQRGLLQS 164
PRK13808 PRK13808
adenylate kinase; Provisional
 17-128 1.05e-15

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 72.61  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  17 WLLDGFPRTLPQAEALDR-----AYQIDTVINLNVPFEVIKQRLTARwihPASGRVyniefnppktvgiddlTGEPLiqR 91
Cdd:PRK13808  81 FILDGFPRTVPQAEALDAllkdkQLKLDAVVELRVNEGALLARVETR---VAEMRA----------------RGEEV--R 139

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 315434223  92 EDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSG 128
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDG 176
PRK14527 PRK14527
adenylate kinase; Provisional
 8-131 1.38e-14

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 67.51  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   8 ELKNLTQYSWLLDGFPRTLPQAEALDR-----AYQIDTVINLNVPFEVIKQRLTARwihpasGRvyniefnppktvgidd 82
Cdd:PRK14527  77 ELAGMEPVRVIFDGFPRTLAQAEALDRlleelGARLLAVVLLEVPDEELIRRIVER------AR---------------- 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 315434223  83 ltgepLIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET 131
Cdd:PRK14527 135 -----QEGRSDDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 8-122 1.57e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 67.90  E-value: 1.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   8 ELKNLTQ---YSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIE-----------FN 73
Cdd:PTZ00088  77 EIAKVTDdcfKGFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIAhirsdpydmppIL 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 315434223  74 PPKtvGIDDLTGEP-LIQREDDKPETVIKRLKAYEDQTKPVLEYYQKKGV 122
Cdd:PTZ00088 157 PPA--DCEGCKGNPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14528 PRK14528
adenylate kinase; Provisional
 17-131 2.35e-13

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 64.26  E-value: 2.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  17 WLLDGFPRTLPQAEALDR-----AYQIDTVINLNVPFEVIKQRLTARWIHPAsgrvyniefnppktvgiddltgepliqR 91
Cdd:PRK14528  82 FLLDGFPRTVEQADALDAllkneGKSIDKAINLEVPDGELLKRLLGRAEIEG---------------------------R 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 315434223  92 EDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET 131
Cdd:PRK14528 135 ADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 15-129 2.23e-11

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 58.92  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   15 YSWLLDGFPRTLPQAEA----LDRAYQIDTVINLNVPFEVIKQRLTARwiHPASGRVyniefnppktvgiddltgepliq 90
Cdd:TIGR01359  79 KKFLIDGFPRNEENLEAweklMDNKVNFKFVLFFDCPEETMIKRLLKR--GQTSGRV----------------------- 133

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 315434223   91 reDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGT 129
Cdd:TIGR01359 134 --DDNIETLKKRFRTYNEETLPIIEHFENKGKVKEINAE 170
PRK14529 PRK14529
adenylate kinase; Provisional
 6-120 2.39e-11

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 59.35  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   6 LHELKNLTQYSWLLDGFPRTLPQAEALDRAYQ-----IDTVINLNVPFEVIKQRLTARWI------HPAsgrvyNIEFNP 74
Cdd:PRK14529  69 LETLKQDGKNGWLLDGFPRNKVQAEKLWEALQkegmkLDYVIEILLPREVAKNRIMGRRLckndnnHPN-----NIFIDA 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 315434223  75 PKTVG-IDDLTGEPLIQREDDKPETVI-KRLKAYEDQTKPVLE--YYQKK 120
Cdd:PRK14529 144 IKPDGdVCRVCGGELSTRADDQDEEAInKRHDIYYDTETGTLAaaYFFKD 193
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 17-125 5.69e-09

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 52.51  E-value: 5.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   17 WLLDGFPRTLPQAEALDRAYQ-IDTVINLNVPFEVIKQRLTARwiHPASGRVyniefnppktvgiddltgepliqreDDK 95
Cdd:TIGR01360  85 FLIDGYPREVKQGEEFERRIGpPTLVLYFDCSEDTMVKRLLKR--AETSGRV-------------------------DDN 137

                          90       100       110
                  ....*....|....*....|....*....|
gi 315434223   96 PETVIKRLKAYEDQTKPVLEYYQKKGVLET 125
Cdd:TIGR01360 138 EKTIKKRLETYYKATEPVIAYYETKGKLRK 167
PLN02200 PLN02200
adenylate kinase family protein
 3-145 4.34e-06

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 44.88  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223   3 RLALHELKNLTQYSWLLDGFPRTLPQAEALDR--AYQIDTVINLNVPFEVIKQRLTARwihpASGRVyniefnppktvgi 80
Cdd:PLN02200 109 KLIQKEMESSDNNKFLIDGFPRTEENRIAFERiiGAEPNVVLFFDCPEEEMVKRVLNR----NQGRV------------- 171

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315434223  81 ddltgepliqreDDKPETVIKRLKAYEDQTKPVLEYYQKKGVLETFSGTET-----NKIWPYVYAFLQTK 145
Cdd:PLN02200 172 ------------DDNIDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvdeifEQVRPIFAACEAMK 229
AAA_17 pfam13207
AAA domain;
17-71 1.28e-05

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 42.23  E-value: 1.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 315434223   17 WLLDGFPRTLPQAEALD-------RAYQIDTVINLNVPFEVIKQRLTARwihPASGRVY-NIE 71
Cdd:pfam13207  74 VIVDGHPRIKTPAGYLPglpvevlRELKPDAIILLEADPEEILERRLKD---RTRGRDDdSEE 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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