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Conserved domains on  [gi|315630349|ref|NP_001186827|]
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pyruvate dehydrogenase kinase, isozyme 2 isoform 2 [Homo sapiens]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 132-297 7.10e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 253.80  E-value: 7.10e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 132 NVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINaanskqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLILPPIK 210
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 211 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 282
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 315630349 283 FSMEGFGTDAVIYLK 297
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-128 2.01e-52

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 170.38  E-value: 2.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349    1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYgdd 80
Cdd:pfam10436  38 IRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVVPTLAQGVLELKKYL--- 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 315630349   81 pvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 128
Cdd:pfam10436 112 --SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 132-297 7.10e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 253.80  E-value: 7.10e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 132 NVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINaanskqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLILPPIK 210
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 211 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 282
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 315630349 283 FSMEGFGTDAVIYLK 297
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-128 2.01e-52

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 170.38  E-value: 2.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349    1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYgdd 80
Cdd:pfam10436  38 IRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVVPTLAQGVLELKKYL--- 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 315630349   81 pvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 128
Cdd:pfam10436 112 --SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 178-297 6.56e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 83.47  E-value: 6.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349   178 PSHLYHMLFELFKNAMRATVEShesslilPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggt 257
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 315630349   258 plAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
Cdd:smart00387  72 --GGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 177-297 3.35e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.86  E-value: 3.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349  177 VPSHLYHMLFELFKNAMRATVESHEsslilppIKVMVAlGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTPQPGtgg 256
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGE-------ITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 315630349  257 tplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
Cdd:pfam02518  70 ----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
131-296 8.23e-11

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 61.46  E-value: 8.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKLLCDKYYmaspdleiQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVEShesslilPPIK 210
Cdd:COG2205   91 VDLAELLEEAVEELRPLAEEKG--------IRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 211 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESEPGGGT 228


                 ....*.
gi 315630349 291 DAVIYL 296
Cdd:COG2205  229 TFTVTL 234
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 171-290 3.78e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 48.78  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 171 PIHMVYVPSHLYHMLFELFKNAMRATVESHesslilppIKVMV-ALGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPT 249
Cdd:PRK11091 389 PHKVITDGTRLRQILWNLISNAVKFTQQGG--------VTVRVrYEEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQVKD 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 315630349 250 pqpGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:PRK11091 460 ---SHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 132-297 7.10e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 253.80  E-value: 7.10e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 132 NVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINaanskqPIHMVYVPSHLYHMLFELFKNAMRATVESHE-SSLILPPIK 210
Cdd:cd16929    1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDP------SIRFPYVPSHLYYILFELLKNAMRATVESHGdDSDDLPPIK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 211 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQ--------PGTGGTPLAGFGYGLPISRLYAKYFQGDLQL 282
Cdd:cd16929   75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSlddfsdliSGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                        170
                 ....*....|....*
gi 315630349 283 FSMEGFGTDAVIYLK 297
Cdd:cd16929  155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-128 2.01e-52

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 170.38  E-value: 2.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349    1 MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHrtlSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYgdd 80
Cdd:pfam10436  38 IRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDN---EKFTELLEEILDRHNDVVPTLAQGVLELKKYL--- 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 315630349   81 pvSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSID 128
Cdd:pfam10436 112 --SPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQSNNPSHPPDyVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 178-297 6.56e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 83.47  E-value: 6.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349   178 PSHLYHMLFELFKNAMRATVEShesslilPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggt 257
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKI---- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 315630349   258 plAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
Cdd:smart00387  72 --GGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 177-297 3.35e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.86  E-value: 3.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349  177 VPSHLYHMLFELFKNAMRATVESHEsslilppIKVMVAlGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPTPQPGtgg 256
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGE-------ITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 315630349  257 tplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK 297
Cdd:pfam02518  70 ----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
131-296 8.23e-11

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 61.46  E-value: 8.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKLLCDKYYmaspdleiQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVEShesslilPPIK 210
Cdd:COG2205   91 VDLAELLEEAVEELRPLAEEKG--------IRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPG-------GTIT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 211 VMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-------GTGLGLAIVKRIVEAHGGTIWVESEPGGGT 228


                 ....*.
gi 315630349 291 DAVIYL 296
Cdd:COG2205  229 TFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
132-296 2.18e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 61.08  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 132 NVSEVVKDAYDMAKLLCdkyymASPDLEIqEINAANSKQPIHMVyvPSHLYHMLFELFKNAMRATVESHesslilpPIKV 211
Cdd:COG0642  183 DLAELLEEVVELFRPLA-----EEKGIEL-ELDLPDDLPTVRGD--PDRLRQVLLNLLSNAIKYTPEGG-------TVTV 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 212 MVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGtggtplaGFGYGLPISRLYAKYFQGDLQLFSMEGFGTD 291
Cdd:COG0642  248 SVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-------GTGLGLAIVKRIVELHGGTIEVESEPGKGTT 320


                 ....*
gi 315630349 292 AVIYL 296
Cdd:COG0642  321 FTVTL 325
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 131-296 6.57e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 50.57  E-value: 6.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKLLCdKYYMASPDLEIQEinaanskqPIHMVYV-PSHLYHMLFELFKNAMRATVESHEsslilPPI 209
Cdd:COG4191  215 VDLNELIDEALELLRPRL-KARGIEVELDLPP--------DLPPVLGdPGQLEQVLLNLLINAIDAMEEGEG-----GRI 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 210 KVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQpGTGgtpLagfgyGLPISRLYAKYFQGDLQLFSMEGFG 289
Cdd:COG4191  281 TISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK-GTG---L-----GLSISYGIVEKHGGRIEVESEPGGG 351


                 ....*..
gi 315630349 290 TDAVIYL 296
Cdd:COG4191  352 TTFTITL 358
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 188-296 1.37e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.13  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 188 LFKNAMRATVESHEsslilPPIKVMVALGEE--DLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplAGFGYG 265
Cdd:cd16915    8 LIDNALDALAATGA-----PNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ----------GERGIG 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 315630349 266 LPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 296
Cdd:cd16915   73 LALVRQSVERLGGSITVESEPGGGTTFSIRI 103
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 146-296 2.87e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 48.69  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 146 LLCDKYYMAS---PDLEIqEINAANSKQPIhmvyVPSHLYHMLFELFKNAMRATVESHESSlilPPIKVMVALGEEDLSI 222
Cdd:COG3290  249 LLLGKAARARergIDLTI-DIDSDLPDLPL----SDTDLVTILGNLLDNAIEAVEKLPEEE---RRVELSIRDDGDELVI 320

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315630349 223 KMSDRGGGVPLRKIERLFSYMYSTaptpqPGTGGTplagfGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 296
Cdd:COG3290  321 EVEDSGPGIPEELLEKIFERGFST-----KLGEGR-----GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 181-296 3.06e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 45.47  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 181 LYHMLFELFKNAMRATVESHesslilppiKVMVALGEEDLS-IKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTggtpl 259
Cdd:cd16940   14 LFLLLRNLVDNAVRYSPQGS---------RVEIKLSADDGAvIRVEDNGPGIDEEELEALFERFYRSDGQNYGGS----- 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 315630349 260 agfGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 296
Cdd:cd16940   80 ---GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 171-290 3.78e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 48.78  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 171 PIHMVYVPSHLYHMLFELFKNAMRATVESHesslilppIKVMV-ALGEEDLSIKMSDRGGGVPLRKIERLFSyMYSTAPT 249
Cdd:PRK11091 389 PHKVITDGTRLRQILWNLISNAVKFTQQGG--------VTVRVrYEEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQVKD 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 315630349 250 pqpGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:PRK11091 460 ---SHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 131-296 5.93e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.65  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKllcdkyymasPDLEIQEIN-AANSKQPIHMVYV-PSHLYHMLFELFKNAMRATVEShesslilPP 208
Cdd:COG5000  276 VDLNELLREVLALYE----------PALKEKDIRlELDLDPDLPEVLAdRDQLEQVLINLLKNAIEAIEEG-------GE 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 209 IKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpGTggtplagfGYGLPISRLYAKYFQGDLQLFSMEGF 288
Cdd:COG5000  339 IEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK---GT--------GLGLAIVKKIVEEHGGTIELESRPGG 407


                 ....*...
gi 315630349 289 GTDAVIYL 296
Cdd:COG5000  408 GTTFTIRL 415
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
131-298 2.46e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 45.70  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKLLCDKYymaspDLEIQeinaANSKQPIHMVYV-PSHLYHMLFELFKNAMRATVESHEsslilppI 209
Cdd:COG5002  240 VDLAELLEEVVEELRPLAEEK-----GIELE----LDLPEDPLLVLGdPDRLEQVLTNLLDNAIKYTPEGGT-------I 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 210 KVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTplagfGYGLPISRLYAKYFQGDLQLFSMEGFG 289
Cdd:COG5002  304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGT-----GLGLAIVKHIVEAHGGRIWVESEPGKG 378


                 ....*....
gi 315630349 290 TDAVIYLKA 298
Cdd:COG5002  379 TTFTITLPL 387
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-282 2.50e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 42.83  E-value: 2.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315630349 209 IKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTaPTPQPGTGGTplagfGYGLPISRLYAKYFQGDLQL 282
Cdd:cd16945   26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKST-----GLGLAFVQEVAQLHGGRITL 93
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 185-290 1.60e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.46  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 185 LFELFKNAMRATVESHESSLILPpIKVMVAlGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplaGFGY 264
Cdd:cd16920    5 LINLVRNGIEAMSEGGCERRELT-IRTSPA-DDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE-----------GLGM 71

                         90       100
                 ....*....|....*....|....*.
gi 315630349 265 GLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:cd16920   72 GLSICRSIIEAHGGRLSVESPAGGGA 97
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 220-296 3.09e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 40.06  E-value: 3.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315630349 220 LSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtggtplaGFGYGLPISRLY--AKYFQGDLQLFSMEGFGTDAVIYL 296
Cdd:cd16919   48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEV-----------GKGTGLGLSMVYgfVKQSGGHLRIYSEPGVGTTVRIYL 115
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 180-284 1.13e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 40.83  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 180 HLYHMLFELFKNAMRATVEShesslilPPIKVMVALGEEDLSIKMSDRGGGVPLrkIERLFSYMYSTAPTpqpgtggtpl 259
Cdd:COG4192  543 LLEQVLVNLLVNALDAVATQ-------PQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEV---------- 603

                         90       100
                 ....*....|....*....|....*
gi 315630349 260 aGFGYGLPISRLYAKYFQGDLQLFS 284
Cdd:COG4192  604 -GLGLGLSICRSIMQQFGGDLYLAS 627
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 188-296 1.21e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 40.34  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 188 LFKNAMRATVEshesslilpPIKVMVALGEED---LSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpgtgGTplagfGY 264
Cdd:COG5809  387 LLKNAIEAMPE---------GGNITIETKAEDddkVVISVTDEGCGIPEERLKKLGEPFYTTKEK------GT-----GL 446

                         90       100       110
                 ....*....|....*....|....*....|..
gi 315630349 265 GLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL 296
Cdd:COG5809  447 GLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
185-303 1.88e-03

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 39.95  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 185 LFELFKNAMRATVESHEsslilppIKVMVAL-GEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpGTggtplagfG 263
Cdd:PRK11360 505 LLNILINAVQAISARGK-------IRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK---GT--------G 566

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 315630349 264 YGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDS 303
Cdd:PRK11360 567 LGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 184-290 2.70e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 37.09  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 184 MLFELFKNAMRATVESHesslilppIKVMVALGEED-----LSIKMSDRGGGVPLRKIERLFSyMYSTAPTP-QPGTGGT 257
Cdd:cd16922    4 ILLNLLGNAIKFTEEGE--------VTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFE-PFSQADSStTRKYGGT 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 315630349 258 plagfGYGLPISRLYAKYFQGDLQLFSMEGFGT 290
Cdd:cd16922   75 -----GLGLAISKKLVELMGGDISVESEPGQGS 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 209-300 3.82e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 39.06  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 209 IKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYStapTPQPGTG--GTplagfGYGLPISRLYAKYFQGDLQLFSME 286
Cdd:PRK11100 390 ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYS---LPRPANGrkST-----GLGLAFVREVARLHGGEVTLRNRP 461

                         90
                 ....*....|....
gi 315630349 287 GFGTDAVIYLKALS 300
Cdd:PRK11100 462 EGGVLATLTLPRHF 475
PRK14867 PRK14867
DNA topoisomerase VI subunit B; Provisional
 173-243 5.87e-03

DNA topoisomerase VI subunit B; Provisional


Pssm-ID: 237841 [Multi-domain]  Cd Length: 659  Bit Score: 38.64  E-value: 5.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315630349 173 HMVYVPSHLYHM---LFELFKNAMRATveshESSLILPPIKVMVA-LGEEDLSIKMSDRGGGVPLRKIERLFSYM 243
Cdd:PRK14867  26 HMLGYSGKLRSMttiIHELVTNSLDAC----EEAEILPDIKVEIEkLGSDHYKVAVEDNGPGIPPEFVPKVFGKM 96
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
131-303 6.56e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 37.90  E-value: 6.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 131 CNVSEVVKDAYDMAKLLCDKyymaspDLEIQEiNAANSkqpIHMVYV-PSHLYHMLFELFKNAMRATVESHE---SSLIL 206
Cdd:COG3852  204 VNLHEVLERVLELLRAEAPK------NIRIVR-DYDPS---LPEVLGdPDQLIQVLLNLVRNAAEAMPEGGTitiRTRVE 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315630349 207 PPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTpqpGTGgtpLagfgyGLPISRLYAKYFQGDLQLFSME 286
Cdd:COG3852  274 RQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK---GTG---L-----GLAIVQKIVEQHGGTIEVESEP 342

                        170
                 ....*....|....*..
gi 315630349 287 GFGTDAVIYLKALSTDS 303
Cdd:COG3852  343 GKGTTFRIYLPLEQAEE 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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