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Conserved domains on  [gi|319655720|ref|NP_001188331|]
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galactocerebrosidase isoform d [Homo sapiens]

Protein Classification

glycoside hydrolase family 30 protein( domain architecture ID 13670604)

glycoside hydrolase family 30 protein similar to mammalian lysosomal acid glucosylceramidase that catalyzes the hydrolysis of glucosylceramide into free ceramide and glucose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
40-323 2.91e-142

Glycosyl hydrolase family 59;


:

Pssm-ID: 396577  Cd Length: 293  Bit Score: 415.96  E-value: 2.91e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720   40 ATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWLMKEAKKRNPNI 118
Cdd:pfam02057  11 ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWLMAEAKKRNPDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  119 TLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKMLNYQGLQRVKI 197
Cdd:pfam02057  91 KLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPALDAYGYKKIKI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  198 IASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWGRILNQNYINGY 274
Cdd:pfam02057 168 VASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIARRINRNYVNGR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 319655720  275 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 323
Cdd:pfam02057 245 MTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
331-438 3.88e-58

Glycosyl hydrolase family 59 central domain;


:

Pssm-ID: 465411  Cd Length: 116  Bit Score: 191.26  E-value: 3.88e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  331 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 409
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80

                          90       100
                  ....*....|....*....|....*....
gi 319655720  410 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 438
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
 
Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
40-323 2.91e-142

Glycosyl hydrolase family 59;


Pssm-ID: 396577  Cd Length: 293  Bit Score: 415.96  E-value: 2.91e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720   40 ATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWLMKEAKKRNPNI 118
Cdd:pfam02057  11 ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWLMAEAKKRNPDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  119 TLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKMLNYQGLQRVKI 197
Cdd:pfam02057  91 KLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPALDAYGYKKIKI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  198 IASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWGRILNQNYINGY 274
Cdd:pfam02057 168 VASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIARRINRNYVNGR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 319655720  275 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 323
Cdd:pfam02057 245 MTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
331-438 3.88e-58

Glycosyl hydrolase family 59 central domain;


Pssm-ID: 465411  Cd Length: 116  Bit Score: 191.26  E-value: 3.88e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  331 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 409
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80

                          90       100
                  ....*....|....*....|....*....
gi 319655720  410 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 438
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
XynC COG5520
O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];
44-328 6.41e-15

O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444271 [Multi-domain]  Cd Length: 445  Bit Score: 77.57  E-value: 6.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  44 LLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGG--------------DGQTTDGtepshmHYALDENyfRGYEWWLMK 109
Cdd:COG5520   65 LLGKLSAAKRNELLKELFSPEKGIGLSLLRTPIGAsdfslgsysyddvpDGDPDLG------HFSIARD--KKYLIPFLK 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 110 EAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQ---LTAY--YVVTWIvgaKRY--HDLDIDYIGIWNERSYNANY--- 179
Cdd:COG5520  137 EALAINPDLKIMASPWSPPAWMKTNGSMNGGSLKpeyYDAYadYFVKYI---QAYkkEGIPIDALTPQNEPLAPQNWpsc 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 180 ----------IK-ILRKMLNYQGLqRVKIIASDNLWESIS---ASMLLDAELFKVVDVIGAH-YPGTHSAKD---AKLTG 241
Cdd:COG5520  214 lmtaeeqadfIKnYLGPALEKAGL-DTKILAYDHNRDYKPdypITILSDPEAAKYVDGIAFHwYGGDISALSrvhEAFPD 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 242 KKLWSSEdFSTLNSDMGAGCWGRILNQ--NYINGYMTSTIAWNLvASYYEQLPY--GRC-GLMTAqEPWSGHYVVESPVW 316
Cdd:COG5520  293 KNLYFTE-GCGGGWDGDWDGALHYANLiiGDLRNWAKGWLDWNL-ALDENGGPNhgGYCnGLVTI-DTKTGEVTYNPEYY 369

                        330
                 ....*....|..
gi 319655720 317 VSAHTTQFTQPG 328
Cdd:COG5520  370 AIGHFSKFVRPG 381
 
Name Accession Description Interval E-value
Glyco_hydro_59 pfam02057
Glycosyl hydrolase family 59;
40-323 2.91e-142

Glycosyl hydrolase family 59;


Pssm-ID: 396577  Cd Length: 293  Bit Score: 415.96  E-value: 2.91e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720   40 ATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDE-NYFRGYEWWLMKEAKKRNPNI 118
Cdd:pfam02057  11 ATSRLLLDYPEPQRSQILDYLFKPNFGASLQHLKVEIGGDANSSSGTEPSHMRTRDELaDVNRGYEWWLMAEAKKRNPDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  119 TLIGLPWSFPGWLGkgfDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYI-GIWNERSYNANYIKILRKMLNYQGLQRVKI 197
Cdd:pfam02057  91 KLDGLPWGAPGWVG---GGPGFWSEDTYDYLKSWIDGAKRTYGLDIDYIsGLWNERGYDATYVKTLRPALDAYGYKKIKI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  198 IASDNLWE-SISASMLLDAELFKVVDVIGAHYPGTHSAKD--AKLTGKKLWSSEDFSTLNsdmGAGCWGRILNQNYINGY 274
Cdd:pfam02057 168 VASDEAGTwSIADDMLKDPELRDAVDVIGYHYPSTDSSYSnlALATGKPLWASEDLSSLN---SALDIARRINRNYVNGR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 319655720  275 MTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQ 323
Cdd:pfam02057 245 MTSYIFWPLIAAYYPGAPYSGKGLMTANEPWSGYYEVDPGIWATAHTTQ 293
Glyco_hydro_59M pfam17387
Glycosyl hydrolase family 59 central domain;
331-438 3.88e-58

Glycosyl hydrolase family 59 central domain;


Pssm-ID: 465411  Cd Length: 116  Bit Score: 191.26  E-value: 3.88e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  331 YLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLG-KTSE 409
Cdd:pfam17387   1 YLKGVGHLEQGGSYVALTDGLGNLTIIIETMSHNHSQCIRPPLPPYNVSPQNATFRLKGSFANITKLQVWYSKLGfKSNK 80

                          90       100
                  ....*....|....*....|....*....
gi 319655720  410 RFLFKQLDSlwLLDSDGSFTLSLHEDELF 438
Cdd:pfam17387  81 SVLFKKLGP--IKVNNGSFSLKLDVDEVY 107
XynC COG5520
O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];
44-328 6.41e-15

O-Glycosyl hydrolase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444271 [Multi-domain]  Cd Length: 445  Bit Score: 77.57  E-value: 6.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720  44 LLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGG--------------DGQTTDGtepshmHYALDENyfRGYEWWLMK 109
Cdd:COG5520   65 LLGKLSAAKRNELLKELFSPEKGIGLSLLRTPIGAsdfslgsysyddvpDGDPDLG------HFSIARD--KKYLIPFLK 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 110 EAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQ---LTAY--YVVTWIvgaKRY--HDLDIDYIGIWNERSYNANY--- 179
Cdd:COG5520  137 EALAINPDLKIMASPWSPPAWMKTNGSMNGGSLKpeyYDAYadYFVKYI---QAYkkEGIPIDALTPQNEPLAPQNWpsc 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 180 ----------IK-ILRKMLNYQGLqRVKIIASDNLWESIS---ASMLLDAELFKVVDVIGAH-YPGTHSAKD---AKLTG 241
Cdd:COG5520  214 lmtaeeqadfIKnYLGPALEKAGL-DTKILAYDHNRDYKPdypITILSDPEAAKYVDGIAFHwYGGDISALSrvhEAFPD 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319655720 242 KKLWSSEdFSTLNSDMGAGCWGRILNQ--NYINGYMTSTIAWNLvASYYEQLPY--GRC-GLMTAqEPWSGHYVVESPVW 316
Cdd:COG5520  293 KNLYFTE-GCGGGWDGDWDGALHYANLiiGDLRNWAKGWLDWNL-ALDENGGPNhgGYCnGLVTI-DTKTGEVTYNPEYY 369

                        330
                 ....*....|..
gi 319655720 317 VSAHTTQFTQPG 328
Cdd:COG5520  370 AIGHFSKFVRPG 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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