NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|319918857|ref|NP_001188402|]
View 

coronin-7 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-795 5.63e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 5.63e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 386 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 461
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 462 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 541
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 542 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 621
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 622 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 701
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 702 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 773
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918857 774 PPDMSPVSQAPREAPARRAPSS 795
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-343 1.33e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 132.71  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLW 158
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIMLW 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 159 DTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAVM 238
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 239 SCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCLV 315
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGASA 400

                        250       260
                 ....*....|....*....|....*...
gi 319918857 316 PPAEPLPdtaQPAVMETPVGDADASEGF 343
Cdd:PTZ00421 401 LSPSGKP---RHSGVSVPASTSAMTHSF 425
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-60 2.92e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


:

Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.52  E-value: 2.92e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857    3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFN--SDRPGVLGIVPL 60
Cdd:pfam08953   2 FVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPL 61
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 386-795 5.63e-70

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 5.63e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 386 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 461
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 462 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 541
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 542 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 621
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 622 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 701
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 702 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 773
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918857 774 PPDMSPVSQAPREAPARRAPSS 795
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 79-343 1.33e-32

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 132.71  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLW 158
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIMLW 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 159 DTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAVM 238
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 239 SCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCLV 315
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGASA 400

                        250       260
                 ....*....|....*....|....*...
gi 319918857 316 PPAEPLPdtaQPAVMETPVGDADASEGF 343
Cdd:PTZ00421 401 LSPSGKP---RHSGVSVPASTSAMTHSF 425
WD40 COG2319
WD40 repeat [General function prediction only];
460-675 5.27e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 5.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 460 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 539
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 540 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 619
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 319918857 620 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 675
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 461-619 9.64e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 9.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 461 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 540
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 541 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 617
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 319918857 618 SQ 619
Cdd:cd00200  199 GT 200
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 723-767 3.40e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.85  E-value: 3.40e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918857  723 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 767
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 253-295 3.21e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.46  E-value: 3.21e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 319918857  253 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 295
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-60 2.92e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.52  E-value: 2.92e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857    3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFN--SDRPGVLGIVPL 60
Cdd:pfam08953   2 FVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPL 61
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 548-579 2.84e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.84e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 319918857   548 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 579
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-210 5.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  75 CHSELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRdSRLAWMGTWEHLVSTGFNqmreRE 154
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD----GT 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 319918857 155 VKLWDTRFFSSaLASLT--LDTSLGCLVpllDPDsGLLVLAGKGERQLYCYEVVPQQP 210
Cdd:cd00200  201 IKLWDLSTGKC-LGTLRghENGVNSVAF---SPD-GYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
69-161 9.33e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  69 RVAHLGCHSELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFN 148
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTS-VAFSPDGKLLASGSDD 183

                         90
                 ....*....|...
gi 319918857 149 qmreREVKLWDTR 161
Cdd:COG2319  184 ----GTVRLWDLA 192
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 386-795 5.63e-70

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 5.63e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 386 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 461
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 462 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 541
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 542 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 621
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 622 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 701
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 702 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 773
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918857 774 PPDMSPVSQAPREAPARRAPSS 795
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00420 PTZ00420
coronin; Provisional
 415-764 4.51e-37

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 147.40  E-value: 4.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 415 ESDGFCANKLRVAVPL-LSSGGQVAVLELRKPGRLPdtalPTLQ---NGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVP 490
Cdd:PTZ00420  30 DSCGIACSSGFVAVPWeVEGGGLIGAIRLENQMRKP----PVIKlkgHTSSILDLQFNPCFSEILASGSEDLTIRVWEIP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 491 A--EGLEEVlTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQgHQDQIFSLAWSPDGQQLA 568
Cdd:PTZ00420 106 HndESVKEI-KDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 569 TVCKDGRVRVYRPRSgPEPLQEGPGPKGGRGARIVWV----CDGRCLLVSGFDSQSERQLLLYEAEALAgGPLAVLGLDV 644
Cdd:PTZ00420 184 GTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKNTT-SALVTMSIDN 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 645 APSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESpfFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLR-LRQSSL 723
Cdd:PTZ00420 262 ASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSI 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 319918857 724 EPVAFRLPRVRKEFFQDDVFPDTaVIWEPVLSAEAWLQGAN 764
Cdd:PTZ00420 340 RPISFYVPRKNPTKFQEDLYPPI-LMHDPERSSRNWIDGKD 379
PTZ00421 PTZ00421
coronin; Provisional
 79-343 1.33e-32

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 132.71  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLW 158
Cdd:PTZ00421 164 IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIMLW 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 159 DTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAVM 238
Cdd:PTZ00421 243 DTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTR 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 239 SCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCLV 315
Cdd:PTZ00421 321 KCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGASA 400

                        250       260
                 ....*....|....*....|....*...
gi 319918857 316 PPAEPLPdtaQPAVMETPVGDADASEGF 343
Cdd:PTZ00421 401 LSPSGKP---RHSGVSVPASTSAMTHSF 425
WD40 COG2319
WD40 repeat [General function prediction only];
460-675 5.27e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 5.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 460 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 539
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 540 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 619
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 319918857 620 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 675
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
391-675 2.51e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.51e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 391 AQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT------LQNGAAVTD 464
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGallatlLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 465 LAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGAD 544
Cdd:COG2319   84 VAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 545 RLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsqseRQL 624
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTV 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 319918857 625 LLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 675
Cdd:COG2319  229 RLWDLA--TGKLLRTLTGHSGSVRSV-AFSPD-GRLLASGSADGTVRLWDL 275
PTZ00420 PTZ00420
coronin; Provisional
 86-300 2.55e-26

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 114.66  E-value: 2.55e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  86 VQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWM----GTWEHLVSTGFNQMREREVKLWDTR 161
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIAS-SFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLK 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 162 FFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVvpQQPALSPVTQCVLESVLRGAALVPRQALAVMSCE 241
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQH--SLGSIRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 319918857 242 VLRVLQ-LSDTAIVPIGYHVPRK-AVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSL 300
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINI 387
WD40 COG2319
WD40 repeat [General function prediction only];
459-617 2.96e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 2.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 459 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 538
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 319918857 539 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFD 617
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
459-583 1.35e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 1.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 459 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVpaeGLEEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 538
Cdd:COG2319  288 SGGVNSVAFSP-DGKLLASGSDDGTVRLWDL---ATGKLLRT----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 319918857 539 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 583
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 461-619 9.64e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 9.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 461 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 540
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 541 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 617
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 319918857 618 SQ 619
Cdd:cd00200  199 GT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 462-580 4.40e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 4.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 462 VTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQA 541
Cdd:cd00200  180 VNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRT 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 319918857 542 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 580
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 461-670 1.49e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 461 AVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 540
Cdd:cd00200   95 YVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 541 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRcLLVSG-- 615
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENG----VNSVAfspDGY-LLASGse 239

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 319918857 616 ------FDSQSERQLllyeaEALAGGPLAVLGLDVAPstllpsydpdTGLVLLTGKGDTRV 670
Cdd:cd00200  240 dgtirvWDLRTGECV-----QTLSGHTNSVTSLAWSP----------DGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 504-584 1.16e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 504 VLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 583
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82


                 .
gi 319918857 584 G 584
Cdd:cd00200   83 G 83
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 723-767 3.40e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.85  E-value: 3.40e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918857  723 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 767
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 385-447 1.23e-13

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 66.37  E-value: 1.23e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 319918857  385 SSKFRHAQGTVLHRDSHITNLKglNLTTPGESDGFCANKLRVAVPLLSSG-GQVAVLELRKPGR 447
Cdd:pfam08953   5 ASKFRHVYGKPAKKELCYDNIK--VTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 253-295 3.21e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.46  E-value: 3.21e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 319918857  253 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 295
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-60 2.92e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.52  E-value: 2.92e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857    3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFN--SDRPGVLGIVPL 60
Cdd:pfam08953   2 FVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPL 61
WD40 COG2319
WD40 repeat [General function prediction only];
474-675 2.19e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 474 RLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAAnVLASSSYDLTVRIWDLQAGADRLKLQGHQD 553
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857 554 QIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGarIVWVCDGRCLLVSGFDsqseRQLLLYEAEalA 633
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS--VAFSPDGKTLASGSAD----GTVRLWDLA--T 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 319918857 634 GGPLAVL-GLDVAPSTLlpSYDPDtGLVLLTGKGDTRVFLYEL 675
Cdd:COG2319  152 GKLLRTLtGHSGAVTSV--AFSPD-GKLLASGSDDGTVRLWDL 191
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 548-579 2.84e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.84e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 319918857   548 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 579
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-210 5.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 5.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  75 CHSELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRdSRLAWMGTWEHLVSTGFNqmreRE 154
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD----GT 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 319918857 155 VKLWDTRFFSSaLASLT--LDTSLGCLVpllDPDsGLLVLAGKGERQLYCYEVVPQQP 210
Cdd:cd00200  201 IKLWDLSTGKC-LGTLRghENGVNSVAF---SPD-GYLLASGSEDGTIRVWDLRTGEC 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 500-538 6.35e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 319918857   500 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 538
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
547-579 8.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 8.64e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 319918857  547 KLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 579
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
500-538 3.65e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.65e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 319918857  500 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 538
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
69-161 9.33e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  69 RVAHLGCHSELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFN 148
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTS-VAFSPDGKLLASGSDD 183

                         90
                 ....*....|...
gi 319918857 149 qmreREVKLWDTR 161
Cdd:COG2319  184 ----GTVRLWDLA 192
WD40 COG2319
WD40 repeat [General function prediction only];
78-161 1.71e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  78 ELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWM--GTWehLVSTGfnqmREREV 155
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRS-VAFSpdGRL--LASGS----ADGTV 270


                 ....*.
gi 319918857 156 KLWDTR 161
Cdd:COG2319  271 RLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
79-161 1.76e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKpRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKLW 158
Cdd:COG2319  326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSAD----GTVRLW 399


                 ...
gi 319918857 159 DTR 161
Cdd:COG2319  400 DLA 402
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 535-579 2.76e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 2.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918857  535 RIWDLQAGADRLKlqghqdqIFSLAWSPDGQQLATVCKDGRVRVY 579
Cdd:pfam12894  28 RVWTLSPDKEDLE-------VTSLAWRPDGKLLAVGYSDGTVRLL 65
WD40 COG2319
WD40 repeat [General function prediction only];
78-161 3.01e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  78 ELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKL 157
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTVRL 230


                 ....
gi 319918857 158 WDTR 161
Cdd:COG2319  231 WDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
79-161 3.23e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRasQSTQAHENSRDSRLAW--MGTWehLVSTGFNQMrereVK 156
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFspDGKL--LASGSDDGT----VR 313


                 ....*
gi 319918857 157 LWDTR 161
Cdd:COG2319  314 LWDLA 318
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 431-584 1.61e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 42.33  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  431 LSSGGQVAVLELR--------KPG---RLPDTAlptlqnGAAVTDLAWDPfDPHRLAVA----GEDArirLWRVPAEGLE 495
Cdd:COG4946   309 LSPDGKRVAFEARgevftvpaEKGptrNLTNTP------GVRERLPAWSP-DGKSIAYFsdasGEYE---LYIAPADGSG 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  496 EV--LTTPETvltghtekicSLRFHPLAANV---LASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWSPDGQQLAT 569
Cdd:COG4946   379 EPkqLTLGDL----------GRVFNPVWSPDgkkIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAY 448

                         170
                  ....*....|....*....
gi 319918857  570 VCKDG----RVRVYRPRSG 584
Cdd:COG4946   449 SKPGPnqlsQIFLYDVETG 467
WD40 COG2319
WD40 repeat [General function prediction only];
79-161 3.12e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  79 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWM--GTWehLVSTGfnqmREREVK 156
Cdd:COG2319  284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSpdGKT--LASGS----DDGTVR 355


                 ....*
gi 319918857 157 LWDTR 161
Cdd:COG2319  356 LWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-161 3.66e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918857  75 CHSELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDprTKPRASQST-QAHENSrDSRLAWMGTWEHLVSTGFNQMrer 153
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD--LETGELLRTlKGHTGP-VRDVAASADGTYLASGSSDKT--- 74


                 ....*...
gi 319918857 154 eVKLWDTR 161
Cdd:cd00200   75 -IRLWDLE 81
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 555-630 7.50e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 7.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 319918857  555 IFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAE 630
Cdd:COG4946   391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASG-KVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVE 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH