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Conserved domains on  [gi|321267489|ref|NP_001189423|]
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highly divergent homeobox [Danio rerio]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10209725)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
16-70 4.97e-05

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 41.33  E-value: 4.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 321267489   16 RSVFTAEQQRILERYYENgmtNQSKSCFQlILQCAQETKLDFSVVRTWVGNKRRK 70
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQE---NPYPSAEE-REELAAQLGLTERQVKVWFQNRRAK 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 423-479 8.87e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.99  E-value: 8.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 321267489 423 RTQFSDRDLYTLKRYWDNGMTslgsLCKEKIAAAAIQLNVDTEIIKTWIGNRRRKYR 479
Cdd:cd00086    4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
16-70 4.97e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 41.33  E-value: 4.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 321267489   16 RSVFTAEQQRILERYYENgmtNQSKSCFQlILQCAQETKLDFSVVRTWVGNKRRK 70
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQE---NPYPSAEE-REELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 16-70 1.96e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 39.54  E-value: 1.96e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 321267489    16 RSVFTAEQQRILERYYENgmtNQSKSCFQlILQCAQETKLDFSVVRTWVGNKRRK 70
Cdd:smart00389   5 RTSFTPEQLEELEKEFQK---NPYPSREE-REELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 16-71 5.98e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 38.38  E-value: 5.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 321267489  16 RSVFTAEQQRILERYYENgmtNQSKSCFQLIlQCAQETKLDFSVVRTWVGNKRRKL 71
Cdd:cd00086    4 RTRFTPEQLEELEKEFEK---NPYPSREERE-ELAKELGLTERQVKIWFQNRRAKL 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 423-479 8.87e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.99  E-value: 8.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 321267489 423 RTQFSDRDLYTLKRYWDNGMTslgsLCKEKIAAAAIQLNVDTEIIKTWIGNRRRKYR 479
Cdd:cd00086    4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
Homeodomain pfam00046
Homeodomain;
423-479 1.57e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.09  E-value: 1.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321267489  423 RTQFSDRDLYTLKRYWDNGMTslgsLCKEKIAAAAIQLNVDTEIIKTWIGNRRRKYR 479
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
16-70 4.97e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 41.33  E-value: 4.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 321267489   16 RSVFTAEQQRILERYYENgmtNQSKSCFQlILQCAQETKLDFSVVRTWVGNKRRK 70
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQE---NPYPSAEE-REELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 16-70 1.96e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 39.54  E-value: 1.96e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 321267489    16 RSVFTAEQQRILERYYENgmtNQSKSCFQlILQCAQETKLDFSVVRTWVGNKRRK 70
Cdd:smart00389   5 RTSFTPEQLEELEKEFQK---NPYPSREE-REELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 16-71 5.98e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 38.38  E-value: 5.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 321267489  16 RSVFTAEQQRILERYYENgmtNQSKSCFQLIlQCAQETKLDFSVVRTWVGNKRRKL 71
Cdd:cd00086    4 RTRFTPEQLEELEKEFEK---NPYPSREERE-ELAKELGLTERQVKIWFQNRRAKL 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 423-479 8.87e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.99  E-value: 8.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 321267489 423 RTQFSDRDLYTLKRYWDNGMTslgsLCKEKIAAAAIQLNVDTEIIKTWIGNRRRKYR 479
Cdd:cd00086    4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
Homeodomain pfam00046
Homeodomain;
423-479 1.57e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.09  E-value: 1.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321267489  423 RTQFSDRDLYTLKRYWDNGMTslgsLCKEKIAAAAIQLNVDTEIIKTWIGNRRRKYR 479
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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