metastasis-associated protein MTA1 isoform MTA1s [Homo sapiens]
BAH_MTA and SANT_MTA3_like domain-containing protein( domain architecture ID 10140461)
protein containing domains BAH_MTA, ELM2, and SANT_MTA3_like
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
BAH_MTA | cd04709 | BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ... |
3-188 | 2.26e-97 | ||||
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions. : Pssm-ID: 240060 Cd Length: 164 Bit Score: 288.52 E-value: 2.26e-97
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SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
287-332 | 3.10e-24 | ||||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. : Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 94.22 E-value: 3.10e-24
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
167-219 | 4.23e-16 | ||||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. : Pssm-ID: 460214 Cd Length: 53 Bit Score: 71.87 E-value: 4.23e-16
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Name | Accession | Description | Interval | E-value | ||||
BAH_MTA | cd04709 | BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ... |
3-188 | 2.26e-97 | ||||
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions. Pssm-ID: 240060 Cd Length: 164 Bit Score: 288.52 E-value: 2.26e-97
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SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
287-332 | 3.10e-24 | ||||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 94.22 E-value: 3.10e-24
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BAH | pfam01426 | BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ... |
4-164 | 1.50e-22 | ||||
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction. Pssm-ID: 460207 Cd Length: 120 Bit Score: 91.98 E-value: 1.50e-22
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BAH | smart00439 | Bromo adjacent homology domain; |
5-164 | 1.24e-17 | ||||
Bromo adjacent homology domain; Pssm-ID: 214664 [Multi-domain] Cd Length: 121 Bit Score: 78.49 E-value: 1.24e-17
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
167-219 | 4.23e-16 | ||||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 71.87 E-value: 4.23e-16
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
287-331 | 1.63e-06 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 44.80 E-value: 1.63e-06
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
286-333 | 1.61e-05 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 41.83 E-value: 1.61e-05
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Name | Accession | Description | Interval | E-value | ||||
BAH_MTA | cd04709 | BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ... |
3-188 | 2.26e-97 | ||||
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions. Pssm-ID: 240060 Cd Length: 164 Bit Score: 288.52 E-value: 2.26e-97
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SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
287-332 | 3.10e-24 | ||||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 94.22 E-value: 3.10e-24
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BAH | cd04370 | BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ... |
3-160 | 4.70e-23 | ||||
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions. Pssm-ID: 239835 [Multi-domain] Cd Length: 123 Bit Score: 93.61 E-value: 4.70e-23
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BAH | pfam01426 | BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ... |
4-164 | 1.50e-22 | ||||
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction. Pssm-ID: 460207 Cd Length: 120 Bit Score: 91.98 E-value: 1.50e-22
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BAH | smart00439 | Bromo adjacent homology domain; |
5-164 | 1.24e-17 | ||||
Bromo adjacent homology domain; Pssm-ID: 214664 [Multi-domain] Cd Length: 121 Bit Score: 78.49 E-value: 1.24e-17
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
167-219 | 4.23e-16 | ||||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 71.87 E-value: 4.23e-16
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
287-331 | 1.63e-06 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 44.80 E-value: 1.63e-06
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
286-333 | 1.61e-05 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 41.83 E-value: 1.61e-05
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
287-331 | 2.51e-05 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 41.41 E-value: 2.51e-05
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Blast search parameters | ||||
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