NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|323362963|ref|NP_001191037|]
View 

bcl-2-like protein 11 isoform 13 [Homo sapiens]

Protein Classification

Bim_N and Bclx_interact domain-containing protein( domain architecture ID 10274497)

Bim_N and Bclx_interact domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Bim_N super family cl06026
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.32e-10

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


The actual alignment was detected with superfamily member pfam06773:

Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.94  E-value: 1.32e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 323362963    4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 136-166 2.30e-08

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


:

Pssm-ID: 462643  Cd Length: 38  Bit Score: 47.95  E-value: 2.30e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 323362963  136 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 166
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.32e-10

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.94  E-value: 1.32e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 323362963    4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 136-166 2.30e-08

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 47.95  E-value: 2.30e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 323362963  136 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 166
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.32e-10

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.94  E-value: 1.32e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 323362963    4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 136-166 2.30e-08

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 47.95  E-value: 2.30e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 323362963  136 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 166
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH