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Conserved domains on  [gi|323510698|ref|NP_001191123|]
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signal recognition particle 19 kDa protein isoform 3 [Homo sapiens]

Protein Classification

signal recognition particle subunit SRP19/SEC65 family protein( domain architecture ID 10487531)

signal recognition particle subunit SRP19/SEC65 family protein may be a component of the signal recognition particle (SRP), which is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences

CATH:  3.30.56.30
Gene Ontology:  GO:0006614|GO:0008312|GO:0048500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-91 1.05e-23

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


:

Pssm-ID: 460383  Cd Length: 94  Bit Score: 87.15  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698   17 CIYPAYLNNKKTIAEGRRIPISK------------------------KNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 72
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELavenptakeiadackklglpvvvePDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75

                          90
                  ....*....|....*....
gi 323510698   73 QFPSRKSVMLYAAEMIPKL 91
Cdd:pfam01922  76 EIKNKKQLLKKIAEYIKKL 94
 
Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-91 1.05e-23

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


Pssm-ID: 460383  Cd Length: 94  Bit Score: 87.15  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698   17 CIYPAYLNNKKTIAEGRRIPISK------------------------KNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 72
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELavenptakeiadackklglpvvvePDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75

                          90
                  ....*....|....*....
gi 323510698   73 QFPSRKSVMLYAAEMIPKL 91
Cdd:pfam01922  76 EIKNKKQLLKKIAEYIKKL 94
SEC65 COG1400
Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular ...
 16-61 1.05e-04

Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441010  Cd Length: 96  Bit Score: 38.26  E-value: 1.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698  16 ICIYPAYLNNKKTIAEGRRIPISK------------------------KNKMYSREWNRDvqyRGRVRVQ 61
Cdd:COG1400    7 IVIWPAYFDASLSRSEGRRVPRELavekptleeiakaakklglnpeveRDKKYPRRWWEK---SGRVVVE 73
Sig_rec_Srp19_Halo NF041311
signal recognition particle subunit SRP19;
18-73 1.95e-03

signal recognition particle subunit SRP19;


Pssm-ID: 469208  Cd Length: 93  Bit Score: 35.10  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698  18 IYPAYLNNKKTIAEGRRIPIS------------------------KKNKMYSREWNRDvqyRGRVRVQLKQEDGSLCLVQ 73
Cdd:NF041311   6 IWPAYFDAELSRSEGRRVPEDlaveeptvdeiakavqqvgydaviERDVAYPREHWEE---RGRVLVKDADDAGKNDLVQ 82
 
Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-91 1.05e-23

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


Pssm-ID: 460383  Cd Length: 94  Bit Score: 87.15  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698   17 CIYPAYLNNKKTIAEGRRIPISK------------------------KNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 72
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELavenptakeiadackklglpvvvePDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75

                          90
                  ....*....|....*....
gi 323510698   73 QFPSRKSVMLYAAEMIPKL 91
Cdd:pfam01922  76 EIKNKKQLLKKIAEYIKKL 94
SEC65 COG1400
Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular ...
 16-61 1.05e-04

Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441010  Cd Length: 96  Bit Score: 38.26  E-value: 1.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698  16 ICIYPAYLNNKKTIAEGRRIPISK------------------------KNKMYSREWNRDvqyRGRVRVQ 61
Cdd:COG1400    7 IVIWPAYFDASLSRSEGRRVPRELavekptleeiakaakklglnpeveRDKKYPRRWWEK---SGRVVVE 73
Sig_rec_Srp19_Halo NF041311
signal recognition particle subunit SRP19;
18-73 1.95e-03

signal recognition particle subunit SRP19;


Pssm-ID: 469208  Cd Length: 93  Bit Score: 35.10  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510698  18 IYPAYLNNKKTIAEGRRIPIS------------------------KKNKMYSREWNRDvqyRGRVRVQLKQEDGSLCLVQ 73
Cdd:NF041311   6 IWPAYFDAELSRSEGRRVPEDlaveeptvdeiakavqqvgydaviERDVAYPREHWEE---RGRVLVKDADDAGKNDLVQ 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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