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Conserved domains on  [gi|324120972|ref|NP_001191222|]
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mucin-1 isoform 17 precursor [Homo sapiens]

Protein Classification

SEA domain-containing protein( domain architecture ID 10640846)

SEA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 55-158 5.90e-38

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


:

Pssm-ID: 214554  Cd Length: 121  Bit Score: 127.14  E-value: 5.90e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120972    55 STGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFREGTI 130
Cdd:smart00200   4 SFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNEGVT 83

                           90       100
                   ....*....|....*....|....*...
gi 324120972   131 NVHDVETQFNQYKTEAAsrYNLTISDVS 158
Cdd:smart00200  84 NGQDVEEDLLQVIKQAA--YSLKITNVN 109
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 55-158 5.90e-38

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 127.14  E-value: 5.90e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120972    55 STGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFREGTI 130
Cdd:smart00200   4 SFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNEGVT 83

                           90       100
                   ....*....|....*....|....*...
gi 324120972   131 NVHDVETQFNQYKTEAAsrYNLTISDVS 158
Cdd:smart00200  84 NGQDVEEDLLQVIKQAA--YSLKITNVN 109
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 60-126 1.64e-10

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 55.71  E-value: 1.64e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324120972   60 FFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 126
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 55-158 5.90e-38

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 127.14  E-value: 5.90e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324120972    55 STGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQG----GFLGLSNIKFRPGSVVVQLTLAFREGTI 130
Cdd:smart00200   4 SFGVSLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkpDFVGTEVIEFRNGSVVVDLGLLFNEGVT 83

                           90       100
                   ....*....|....*....|....*...
gi 324120972   131 NVHDVETQFNQYKTEAAsrYNLTISDVS 158
Cdd:smart00200  84 NGQDVEEDLLQVIKQAA--YSLKITNVN 109
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 60-126 1.64e-10

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 55.71  E-value: 1.64e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324120972   60 FFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQ----GGFLGLSNIKFRP--GSVVVQLTLAFR 126
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslrKQYIKSHVLRLRPdgGSVVVDVVLVFR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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