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Conserved domains on  [gi|324120974|ref|NP_001191223|]
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mucin-1 isoform 18 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA super family cl02507
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 71-127 4.16e-14

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


The actual alignment was detected with superfamily member smart00200:

Pssm-ID: 470595  Cd Length: 121  Bit Score: 66.28  E-value: 4.16e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 324120974    71 PGSVVVQLTLAFREGTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 127
Cdd:smart00200  67 NGSVVVDLGLLFNEGVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 71-127 4.16e-14

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 66.28  E-value: 4.16e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 324120974    71 PGSVVVQLTLAFREGTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 127
Cdd:smart00200  67 NGSVVVDLGLLFNEGVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
 
Name Accession Description Interval E-value
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 71-127 4.16e-14

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 66.28  E-value: 4.16e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 324120974    71 PGSVVVQLTLAFREGTINVHDVETQFNQYKTEAAsrYNLTISDVSVSDVPFPFSAQS 127
Cdd:smart00200  67 NGSVVVDLGLLFNEGVTNGQDVEEDLLQVIKQAA--YSLKITNVNVVDVLDPDSADS 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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