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Conserved domains on  [gi|325974475|ref|NP_001191826|]
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transmembrane 4 L6 family member 19 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L6_membrane super family cl05399
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 11-146 9.53e-24

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


The actual alignment was detected with superfamily member pfam05805:

Pssm-ID: 461745  Cd Length: 192  Bit Score: 94.17  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325974475   11 SRTCSRILGLSLGTAALFAAGANVALLLPNWDVTYLLRGLLGRHAMLGTGLWGGGLMVLTAAILISLMGWRYGCFSkSGL 90
Cdd:pfam05805   3 TGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-CGN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325974475   91 CRSVLTALLSGGLALLGALICFVTSGVALKDGPFCMFDVSSFNqtqawkYGYPFKD 146
Cdd:pfam05805  82 RCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGSTS------WGYPFKN 131
 
Name Accession Description Interval E-value
L6_membrane pfam05805
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 11-146 9.53e-24

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


Pssm-ID: 461745  Cd Length: 192  Bit Score: 94.17  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325974475   11 SRTCSRILGLSLGTAALFAAGANVALLLPNWDVTYLLRGLLGRHAMLGTGLWGGGLMVLTAAILISLMGWRYGCFSkSGL 90
Cdd:pfam05805   3 TGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-CGN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325974475   91 CRSVLTALLSGGLALLGALICFVTSGVALKDGPFCMFDVSSFNqtqawkYGYPFKD 146
Cdd:pfam05805  82 RCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGSTS------WGYPFKN 131
 
Name Accession Description Interval E-value
L6_membrane pfam05805
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 11-146 9.53e-24

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


Pssm-ID: 461745  Cd Length: 192  Bit Score: 94.17  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325974475   11 SRTCSRILGLSLGTAALFAAGANVALLLPNWDVTYLLRGLLGRHAMLGTGLWGGGLMVLTAAILISLMGWRYGCFSkSGL 90
Cdd:pfam05805   3 TGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-CGN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325974475   91 CRSVLTALLSGGLALLGALICFVTSGVALKDGPFCMFDVSSFNqtqawkYGYPFKD 146
Cdd:pfam05805  82 RCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGSTS------WGYPFKN 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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