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Conserved domains on  [gi|326937412|ref|NP_001192067|]
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leucine-rich repeat-containing protein 51 isoform 7 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
71-155 1.27e-09

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412   71 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLSRITTFDFSGVTKA 149
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 326937412  150 DRTTAE 155
Cdd:pfam14580 154 ERQAAE 159
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
71-155 1.27e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412   71 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLSRITTFDFSGVTKA 149
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 326937412  150 DRTTAE 155
Cdd:pfam14580 154 ERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-123 1.66e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  34 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 113
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 326937412 114 LTLHGNPMEE 123
Cdd:COG4886  187 LDLSNNQITD 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-160 1.04e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  67 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLSRITTFDFSG 145
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 326937412 146 VTKADRTTAEVWKRM 160
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
71-155 1.27e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412   71 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLSRITTFDFSGVTKA 149
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 326937412  150 DRTTAE 155
Cdd:pfam14580 154 ERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-123 1.66e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  34 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 113
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 326937412 114 LTLHGNPMEE 123
Cdd:COG4886  187 LDLSNNQITD 196
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-119 8.10e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 8.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  34 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 113
Cdd:COG4886  185 KELDLSNNQITDL-------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEE 254


                 ....*.
gi 326937412 114 LTLHGN 119
Cdd:COG4886  255 LDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-145 9.60e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 9.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  34 QSLWLNNNVLNDLRDFnqvasqlLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 113
Cdd:COG4886  162 KSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                         90       100       110
                 ....*....|....*....|....*....|..
gi 326937412 114 LTLHGNPMEEEKGyrqyvLCTLSRITTFDFSG 145
Cdd:COG4886  233 LDLSNNQLTDLPE-----LGNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-123 3.25e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 3.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  34 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIdPVLTTFFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 113
Cdd:COG4886  208 EELDLSGNQLTDL-------PEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKT 276

                         90
                 ....*....|
gi 326937412 114 LTLHGNPMEE 123
Cdd:COG4886  277 LDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-160 1.04e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  67 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPMEEEKGYRQYVLCTLSRITTFDFSG 145
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 326937412 146 VTKADRTTAEVWKRM 160
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
LRR_8 pfam13855
Leucine rich repeat;
62-121 1.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 326937412   62 NLAWIDLSFNDLTSIDPvlTTFFNLS---VLYLHGNSIQRLGEvNKLAVLPRLRSLTLHGNPM 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-123 1.84e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326937412  43 LNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRSLTLHGNPME 122
Cdd:COG4886   95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLT 172


                 .
gi 326937412 123 E 123
Cdd:COG4886  173 D 173
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-119 1.17e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 1.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 326937412  68 LSFND--LTSIDpVLTTFFNLSVLYLHGNSIQRLgevNKLAVLPRLRSLTLHGN 119
Cdd:cd21340    7 LYLNDknITKID-NLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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