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Conserved domains on  [gi|333944018|ref|NP_001207418|]
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cadherin-13 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 2.12e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 117.43  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944018  105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 449-542 5.24e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 5.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 449 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 527
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944018 528 GTGTLLITLEDVNDN 542
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-320 5.85e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 5.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 210 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 289
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944018 290 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 320
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-204 1.23e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   122 QVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 201
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944018   202 NRP 204
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
329-430 3.29e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  329 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 406
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944018  407 NEDPlvpdvsYGPSSTATVHITVL 430
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 550-641 2.72e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  550 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 625
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944018  626 GKPPMTNITDLRVQVC 641
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 2.12e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.43  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944018  105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 449-542 5.24e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 5.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 449 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 527
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944018 528 GTGTLLITLEDVNDN 542
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 3.57e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 88.10  E-value: 3.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018    27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 333944018   105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-320 5.85e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 5.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 210 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 289
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944018 290 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 320
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
211-312 1.38e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  211 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 290
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 333944018  291 IIEAQDMAGldVGLTGTATATI 312
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 461-544 7.63e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 7.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   461 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 539
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944018   540 NDNAP 544
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-204 1.23e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   122 QVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 201
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944018   202 NRP 204
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
329-430 3.29e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  329 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 406
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944018  407 NEDPlvpdvsYGPSSTATVHITVL 430
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
449-537 3.77e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  449 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 527
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944018  528 GTGTLLITLE 537
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-434 1.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 328 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 405
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944018 406 enEDPLVPdvsyGPSSTATVHITVLDVNE 434
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 119-202 3.98e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 3.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 119 GSLQVVDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIV 196
Cdd:cd11304   17 LTVSATDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITV 92


                 ....*.
gi 333944018 197 IDQNDN 202
Cdd:cd11304   93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 229-322 7.64e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   229 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 308
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944018   309 TATIMIDDKNDHSP 322
Cdd:smart00112  68 TVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 345-436 3.66e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 3.66e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   345 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 424
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944018   425 VHITVLDVNEGP 436
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
119-197 7.69e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  119 GSLQVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIV 196
Cdd:pfam00028  16 LTVTATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 333944018  197 I 197
Cdd:pfam00028  92 L 92
Cadherin pfam00028
Cadherin domain;
550-641 2.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  550 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 625
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944018  626 GKPPMTNITDLRVQVC 641
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 550-641 3.61e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 550 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 625
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944018 626 GKPPMTNITDLRVQVC 641
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 567-641 1.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944018   567 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 641
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 2.12e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.43  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 333944018  105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 449-542 5.24e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 5.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 449 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 527
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 333944018 528 GTGTLLITLEDVNDN 542
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 3.57e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 88.10  E-value: 3.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018    27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 333944018   105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 210-320 5.85e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 5.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 210 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 289
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 333944018 290 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 320
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
211-312 1.38e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  211 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 290
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 333944018  291 IIEAQDMAGldVGLTGTATATI 312
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 461-544 7.63e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 7.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   461 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 539
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 333944018   540 NDNAP 544
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 122-204 1.23e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   122 QVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 201
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 333944018   202 NRP 204
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
329-430 3.29e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  329 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 406
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 333944018  407 NEDPlvpdvsYGPSSTATVHITVL 430
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
449-537 3.77e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  449 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 527
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 333944018  528 GTGTLLITLE 537
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-434 1.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 328 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 405
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 333944018 406 enEDPLVPdvsyGPSSTATVHITVLDVNE 434
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 119-202 3.98e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 3.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 119 GSLQVVDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIV 196
Cdd:cd11304   17 LTVSATDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITV 92


                 ....*.
gi 333944018 197 IDQNDN 202
Cdd:cd11304   93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 229-322 7.64e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   229 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 308
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 333944018   309 TATIMIDDKNDHSP 322
Cdd:smart00112  68 TVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 345-436 3.66e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 3.66e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018   345 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 424
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 333944018   425 VHITVLDVNEGP 436
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
119-197 7.69e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  119 GSLQVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIV 196
Cdd:pfam00028  16 LTVTATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 333944018  197 I 197
Cdd:pfam00028  92 L 92
Cadherin pfam00028
Cadherin domain;
550-641 2.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018  550 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 625
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 333944018  626 GKPPMTNITDLRVQVC 641
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-202 1.20e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 47.34  E-value: 1.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 333944018 126 SDRPERSK--FRLTGKGVDQEPkGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDN 202
Cdd:cd00031   21 TDLIASSGeiIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 550-641 3.61e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333944018 550 VAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 625
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 333944018 626 GKPPMTNITDLRVQVC 641
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 567-641 1.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 333944018   567 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 641
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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