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Conserved domains on  [gi|335057505|ref|NP_001229391|]
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growth hormone receptor isoform 5 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 49-127 4.88e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 63.98  E-value: 4.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505   49 KEPKFTKCRSPERETFSCHWTDEVhhgTKNLGPI-QLFYTRRNtqewtQEWKECPDYVSAGENS-----CYFNSSFTSIW 122
Cdd:pfam09067   9 EKPEDIKCFSREKEDFTCFWEEEE---DGGLPTTySFSYAYEN-----ETVKECPLYSTSGANStrlfiCFFPKNDVSLF 80


                  ....*
gi 335057505  123 IPYCI 127
Cdd:pfam09067  81 VPLHI 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 149-250 6.07e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 6.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505 149 PDPPIalnwtllNVSLTGIHAD-IQVRWEAPRNadiqKGWMVLEYELQYKEVNETKWKMMD--PILTTSVPVYSLKVDKE 225
Cdd:cd00063    1 PSPPT-------NLRVTDVTSTsVTLSWTPPED----DGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTE 69

                         90       100
                 ....*....|....*....|....*
gi 335057505 226 YEVRVRSkqRNSGNYGEFSEVLYVT 250
Cdd:cd00063   70 YEFRVRA--VNGGGESPPSESVTVT 92
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 49-127 4.88e-13

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 63.98  E-value: 4.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505   49 KEPKFTKCRSPERETFSCHWTDEVhhgTKNLGPI-QLFYTRRNtqewtQEWKECPDYVSAGENS-----CYFNSSFTSIW 122
Cdd:pfam09067   9 EKPEDIKCFSREKEDFTCFWEEEE---DGGLPTTySFSYAYEN-----ETVKECPLYSTSGANStrlfiCFFPKNDVSLF 80


                  ....*
gi 335057505  123 IPYCI 127
Cdd:pfam09067  81 VPLHI 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 149-250 6.07e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 6.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505 149 PDPPIalnwtllNVSLTGIHAD-IQVRWEAPRNadiqKGWMVLEYELQYKEVNETKWKMMD--PILTTSVPVYSLKVDKE 225
Cdd:cd00063    1 PSPPT-------NLRVTDVTSTsVTLSWTPPED----DGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTE 69

                         90       100
                 ....*....|....*....|....*
gi 335057505 226 YEVRVRSkqRNSGNYGEFSEVLYVT 250
Cdd:cd00063   70 YEFRVRA--VNGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
161-244 8.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 8.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505  161 NVSLTGIHAD-IQVRWEAPRNADIQkgwmVLEYELQYKEVNETKWKMMDPIL--TTSVPVYSLKVDKEYEVRVRSkqRNS 237
Cdd:pfam00041   5 NLTVTDVTSTsLTVSWTPPPDGNGP----ITGYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQA--VNG 78


                  ....*..
gi 335057505  238 GNYGEFS 244
Cdd:pfam00041  79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 149-241 2.43e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505   149 PDPPIalnwtllNVSLTGIHAD-IQVRWEAPRNADIqkGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYE 227
Cdd:smart00060   1 PSPPS-------NLRVTDVTSTsVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71

                           90
                   ....*....|....
gi 335057505   228 VRVRSkqRNSGNYG 241
Cdd:smart00060  72 FRVRA--VNGAGEG 83
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 49-127 4.88e-13

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 63.98  E-value: 4.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505   49 KEPKFTKCRSPERETFSCHWTDEVhhgTKNLGPI-QLFYTRRNtqewtQEWKECPDYVSAGENS-----CYFNSSFTSIW 122
Cdd:pfam09067   9 EKPEDIKCFSREKEDFTCFWEEEE---DGGLPTTySFSYAYEN-----ETVKECPLYSTSGANStrlfiCFFPKNDVSLF 80


                  ....*
gi 335057505  123 IPYCI 127
Cdd:pfam09067  81 VPLHI 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 149-250 6.07e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 6.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505 149 PDPPIalnwtllNVSLTGIHAD-IQVRWEAPRNadiqKGWMVLEYELQYKEVNETKWKMMD--PILTTSVPVYSLKVDKE 225
Cdd:cd00063    1 PSPPT-------NLRVTDVTSTsVTLSWTPPED----DGGPITGYVVEYREKGSGDWKEVEvtPGSETSYTLTGLKPGTE 69

                         90       100
                 ....*....|....*....|....*
gi 335057505 226 YEVRVRSkqRNSGNYGEFSEVLYVT 250
Cdd:cd00063   70 YEFRVRA--VNGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
161-244 8.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 8.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505  161 NVSLTGIHAD-IQVRWEAPRNADIQkgwmVLEYELQYKEVNETKWKMMDPIL--TTSVPVYSLKVDKEYEVRVRSkqRNS 237
Cdd:pfam00041   5 NLTVTDVTSTsLTVSWTPPPDGNGP----ITGYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQA--VNG 78


                  ....*..
gi 335057505  238 GNYGEFS 244
Cdd:pfam00041  79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 149-241 2.43e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 2.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057505   149 PDPPIalnwtllNVSLTGIHAD-IQVRWEAPRNADIqkGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYE 227
Cdd:smart00060   1 PSPPS-------NLRVTDVTSTsVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71

                           90
                   ....*....|....
gi 335057505   228 VRVRSkqRNSGNYG 241
Cdd:smart00060  72 FRVRA--VNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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