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Conserved domains on  [gi|335892870|ref|NP_001229462|]
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UNC93-like protein MFSD11 isoform 1 [Homo sapiens]

Protein Classification

UNC93-like protein MFSD11( domain architecture ID 13024469)

unc-93-like protein MFSD11 belongs to the major facilitator superfamily (MFS) of transporters that facilitate the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
11-435 0e+00

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340965  Cd Length: 387  Bit Score: 623.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  11 IIILGVAFMFMFTAFQTCGNVAQTVIRSLNR--TDFHGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSM 88
Cdd:cd17407    1 VIILGVAFMFIFTAFQTCGNIEQTVIKSLNQgnTTFHGSGYTSLAIIYGVFAASNWIAPSVVAVIGPKWSMVVGGLTYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  89 YIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQISESD 168
Cdd:cd17407   81 FIASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSETIGRNSGIFWALLQCSLLFGNLYVYFAFQGKTTISDHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 169 RRTVFIALTVISLVGTVLFFLIRKPDSENvlgedessddqdmevnesaqnnltkavdafkksfklcvtKEMLLLSITTAY 248
Cdd:cd17407  161 RRTVFIVLTVISLVGVVLLFLLRKPPSEP---------------------------------------KEMLLLSVTFAY 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 249 TGLELTFFSGVYGTCIGATNKFGAEEKSLIGLSGIFIGIGEILGGSLFGLLSKN-NRFGRNPVVLLGILVHFIAFYLIFL 327
Cdd:cd17407  202 TGLELTFFSGVYGTCIGNTNKFGEDAKSLIGLSGIFIGIGEILGGGLFGILGKKtNRFGRDPIVLLGFVVHLIAFYLIFL 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 328 NMPGDAPIApvKGTDSSAYIKSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSN 407
Cdd:cd17407  282 NIPSDAPIA--EGTNDSAYIEPSAYVALFCSFLLGFGDSCFNTQIYSILGFMYPEDSAPAFALFKFVQSIAAAIAFFYSN 359
                        410       420
                 ....*....|....*....|....*...
gi 335892870 408 YLLLHWQLLVMVIFGFFGTISFFTVEWE 435
Cdd:cd17407  360 YLLLQWQLLILVVFGFLGTISFFLVEWK 387
 
Name Accession Description Interval E-value
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
11-435 0e+00

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 623.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  11 IIILGVAFMFMFTAFQTCGNVAQTVIRSLNR--TDFHGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSM 88
Cdd:cd17407    1 VIILGVAFMFIFTAFQTCGNIEQTVIKSLNQgnTTFHGSGYTSLAIIYGVFAASNWIAPSVVAVIGPKWSMVVGGLTYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  89 YIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQISESD 168
Cdd:cd17407   81 FIASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSETIGRNSGIFWALLQCSLLFGNLYVYFAFQGKTTISDHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 169 RRTVFIALTVISLVGTVLFFLIRKPDSENvlgedessddqdmevnesaqnnltkavdafkksfklcvtKEMLLLSITTAY 248
Cdd:cd17407  161 RRTVFIVLTVISLVGVVLLFLLRKPPSEP---------------------------------------KEMLLLSVTFAY 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 249 TGLELTFFSGVYGTCIGATNKFGAEEKSLIGLSGIFIGIGEILGGSLFGLLSKN-NRFGRNPVVLLGILVHFIAFYLIFL 327
Cdd:cd17407  202 TGLELTFFSGVYGTCIGNTNKFGEDAKSLIGLSGIFIGIGEILGGGLFGILGKKtNRFGRDPIVLLGFVVHLIAFYLIFL 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 328 NMPGDAPIApvKGTDSSAYIKSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSN 407
Cdd:cd17407  282 NIPSDAPIA--EGTNDSAYIEPSAYVALFCSFLLGFGDSCFNTQIYSILGFMYPEDSAPAFALFKFVQSIAAAIAFFYSN 359
                        410       420
                 ....*....|....*....|....*...
gi 335892870 408 YLLLHWQLLVMVIFGFFGTISFFTVEWE 435
Cdd:cd17407  360 YLLLQWQLLILVVFGFLGTISFFLVEWK 387
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
45-430 9.14e-139

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 402.86  E-value: 9.14e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870   45 HGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSMYIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLT 124
Cdd:pfam05978   7 AYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQGSYLS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  125 INSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQ---ISESDRRTVFIALTVISLVGTVLFFLIRKPDSENVLGE 201
Cdd:pfam05978  87 ENSTRETIERNTSISWAMLQSSLIGGGIFLFIVFQSGGQgdeISDGQIKLLYSVFTAISIVGIVVFAFLPSPDYENVLSS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  202 DESSddqdmevnesaqnnlTKAVDAFKKSFKLCVTKEMLLLSITTAYTGLELTFFSGVYGTCIGATNKFGAEEKSLIGLS 281
Cdd:pfam05978 167 KEKI---------------QSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEVSFWTSIYPTCISFTSKLGTNTTYLIAIY 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  282 GIFIGIGEILGGSLFGLLSKNNR-FGRNPVVLLGILVHFIAFYLIFLNMPGDAPIAPVKGtdSSAYIKSSKEVAILCSFL 360
Cdd:pfam05978 232 SISTGLGQIIGGIFFGPLGKRIRkFGRDPTILLGTLLHLVYFILIYLSFPNDAPLHPTDG--PGLLITPSLYLAFIISFL 309
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  361 LGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSNYLLLHWQLLVMVIFGFFGTISFF 430
Cdd:pfam05978 310 LGFSDACWNTQIYSILADAYPEDSSQAFAVFKFYQSIASCVAFFYSPYLTLYWHLLILTIFSIFATICFF 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-402 4.06e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870   1 MSPESKKLFNIIILGVAFMFMFTAFQTCGNVAQTVIRslnrTDFHGSGYTS---MAIIYGVFSASNLITPSVVAIVGPQL 77
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA----ADLGASPAQAglvVTAYLLGAALGAPLAGRLADRFGRRR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  78 SMFASGLFYS-MYIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYF 156
Cdd:COG2814   77 VLLLGLLLFAlGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 157 AwqgktqISESDRRTVFIALTVISLVGTVLFFLIrkpdsenvlgedessddqdmeVNESAQNNLTKAVDAFKKSFKLCVT 236
Cdd:COG2814  157 L------ADLFGWRWVFLVNAVLALLALLLLLRL---------------------LPESRPAARARLRGSLRELLRRPRL 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 237 KEMLLLSITTAYTGLELTFFSGVYgtcigATNKFGAEEkSLIGLSGIFIGIGEILGGSLFGLLSKnnRFGRNPVVLLGIL 316
Cdd:COG2814  210 LLLLLLAFLLGFGFFALFTYLPLY-----LQEVLGLSA-SAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLL 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 317 VHFIAFYLIFLNmpgdapiapvkgtdssayikSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAP-AFAIFKFVQ 395
Cdd:COG2814  282 LLALGLLLLALA--------------------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGrASGLYNSAF 341

                 ....*..
gi 335892870 396 SICAAVA 402
Cdd:COG2814  342 FLGGPLA 348
 
Name Accession Description Interval E-value
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
11-435 0e+00

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 623.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  11 IIILGVAFMFMFTAFQTCGNVAQTVIRSLNR--TDFHGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSM 88
Cdd:cd17407    1 VIILGVAFMFIFTAFQTCGNIEQTVIKSLNQgnTTFHGSGYTSLAIIYGVFAASNWIAPSVVAVIGPKWSMVVGGLTYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  89 YIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQISESD 168
Cdd:cd17407   81 FIASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSETIGRNSGIFWALLQCSLLFGNLYVYFAFQGKTTISDHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 169 RRTVFIALTVISLVGTVLFFLIRKPDSENvlgedessddqdmevnesaqnnltkavdafkksfklcvtKEMLLLSITTAY 248
Cdd:cd17407  161 RRTVFIVLTVISLVGVVLLFLLRKPPSEP---------------------------------------KEMLLLSVTFAY 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 249 TGLELTFFSGVYGTCIGATNKFGAEEKSLIGLSGIFIGIGEILGGSLFGLLSKN-NRFGRNPVVLLGILVHFIAFYLIFL 327
Cdd:cd17407  202 TGLELTFFSGVYGTCIGNTNKFGEDAKSLIGLSGIFIGIGEILGGGLFGILGKKtNRFGRDPIVLLGFVVHLIAFYLIFL 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 328 NMPGDAPIApvKGTDSSAYIKSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSN 407
Cdd:cd17407  282 NIPSDAPIA--EGTNDSAYIEPSAYVALFCSFLLGFGDSCFNTQIYSILGFMYPEDSAPAFALFKFVQSIAAAIAFFYSN 359
                        410       420
                 ....*....|....*....|....*...
gi 335892870 408 YLLLHWQLLVMVIFGFFGTISFFTVEWE 435
Cdd:cd17407  360 YLLLQWQLLILVVFGFLGTISFFLVEWK 387
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
45-430 9.14e-139

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 402.86  E-value: 9.14e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870   45 HGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSMYIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLT 124
Cdd:pfam05978   7 AYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQGSYLS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  125 INSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQ---ISESDRRTVFIALTVISLVGTVLFFLIRKPDSENVLGE 201
Cdd:pfam05978  87 ENSTRETIERNTSISWAMLQSSLIGGGIFLFIVFQSGGQgdeISDGQIKLLYSVFTAISIVGIVVFAFLPSPDYENVLSS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  202 DESSddqdmevnesaqnnlTKAVDAFKKSFKLCVTKEMLLLSITTAYTGLELTFFSGVYGTCIGATNKFGAEEKSLIGLS 281
Cdd:pfam05978 167 KEKI---------------QSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEVSFWTSIYPTCISFTSKLGTNTTYLIAIY 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  282 GIFIGIGEILGGSLFGLLSKNNR-FGRNPVVLLGILVHFIAFYLIFLNMPGDAPIAPVKGtdSSAYIKSSKEVAILCSFL 360
Cdd:pfam05978 232 SISTGLGQIIGGIFFGPLGKRIRkFGRDPTILLGTLLHLVYFILIYLSFPNDAPLHPTDG--PGLLITPSLYLAFIISFL 309
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  361 LGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSNYLLLHWQLLVMVIFGFFGTISFF 430
Cdd:pfam05978 310 LGFSDACWNTQIYSILADAYPEDSSQAFAVFKFYQSIASCVAFFYSPYLTLYWHLLILTIFSIFATICFF 379
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
11-434 1.81e-113

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 338.55  E-value: 1.81e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  11 IIILGVAFMFMFTAFQTCGNVAQTVIRSlnrtdfhGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSMYI 90
Cdd:cd17338    1 VIILSFGFLLIFLAYSALQNLQTSLHEN-------GLGSISLGILYSSFAVSSFIAPLLVKLLGEKITLVLGGLGYAIFI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  91 AVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQIseSDRR 170
Cdd:cd17338   74 ASNIFPIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSIFQLSQVFGNLISLALLNHSKGS--SGTT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 171 TVFIALTVISLVGTVLFFLIRKPDSENVLGEDESSDDQDMEVnesaqnnltkaVDAFKKSFKLCVTKEMLLLSITTAYTG 250
Cdd:cd17338  152 ILFIVFMAIMLVGIILLFFLRGPDNEVITEIESSSVGESMEK-----------KNLFKLPFTLLKDKRFLLLIPLLIYSG 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 251 LELTFFSGVYGTCIGATnkfgAEEKSLIGLSGIFIGIGEILGGSLFGLLSKnNRFGRNPVVLLGILVHFIAFYLIFLNMP 330
Cdd:cd17338  221 LEQTFFSGVFTLIIGTP----TTGIARVGYVMAVYGFGDALGSLVAGLLSD-WRFGRIVLAVIGAFVHIASLILLFLSGN 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 331 GDAPIAPvkgtdssayiksSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSNYLL 410
Cdd:cd17338  296 VTPYGLG------------GSWLAYVSAILWGLGDAIFNTQIYALLGSLYENDSESAFAVYKLWQSIATAIAYFLSPYLP 363
                        410       420
                 ....*....|....*....|....
gi 335892870 411 LHWQLLVMVIFGFFGTISFFTVEW 434
Cdd:cd17338  364 LFVKLFVLLALLILLAIFFLFVEL 387
MFS_unc93A_like cd17406
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ...
11-435 6.82e-30

Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340964 [Multi-domain]  Cd Length: 390  Bit Score: 119.67  E-value: 6.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  11 IIILGVAFMFMFTAFQTCGNVaQTvirSLNRTDfhGSGYTSMAIIYGVFSASNLITPSVV-AIVGPQLSMFASGLFYSMY 89
Cdd:cd17406    1 LLVISFAFLLLFTAFQGLQNL-QS---SLNSDD--GLGVVSLSVIYASLIVSCMFLPPLLiKKLGCKWTIVLSMFCYVLY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  90 IAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHS----------IGRNSGIFWALLQSSLFFGNLYIYFAWQ 159
Cdd:cd17406   75 IAANFYPSWYTLIPASIILGFGAAPLWSAKCTYLTESGNRYAkltgksgddvINRFFGIFFMIFQSSQIWGNLISSLVFS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 160 GKTQISESDRRTVFIALTVIslvgTVLFFLirkpDSENVLGEdessddqdmevnESAQNNLTKAVDAFKKSFKLCVTKEM 239
Cdd:cd17406  155 QSLIYTLLGIYLGCGILAVI----IVAVFL----DPLKRDKE------------KRKQETKFSVLSLLLATFKHLKDPRQ 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 240 LLLSITTAYTGLELTFFSGVYgTCIGATNKFGAEEkslIGLSGIFIGIGEILGGSLFGLLSKnnRFGRNPVVLLGILVHF 319
Cdd:cd17406  215 LLLIPLTIYSGLEQAFLSGDF-TKSYVTCALGIWN---VGYVMICFGVVNALCSFLFGRLVK--YTGRIPLFALGALVNL 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 320 ---IAFYLIFLNmPGDapiapvkgtdssayiksskeVAILCSF--LLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFV 394
Cdd:cd17406  289 gliIALLLWEPD-PDQ--------------------LAIFFVFagLWGMADAVWQTQINALYGVLFPKNKEAAFSNYRLW 347
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 335892870 395 QSICAAVAFFYSNYLLLHWQLLVMVIFGFFGTISFFTVEWE 435
Cdd:cd17406  348 ESLGFVIAFAYSNFLCVYVKLYILLAVLLLGMVGYGVVEYI 388
MFS_unc93-like cd06178
Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; ...
10-431 1.57e-11

Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; This subfamily consists of uncharacterized proteins, mainly from fungi and plants, with similarity to Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The unc93-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340867  Cd Length: 415  Bit Score: 65.78  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  10 NIIILGVAFMF--MFTAFQTCGNVAQTVIRSLNrtdfhgsgyTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYS 87
Cdd:cd06178    3 VVLVGLVCFCCpgMFNALTGLGGGGQVDPTVAN---------NANTALYATFAVFGFFGGGIFNLLGPRLTLAFGGTGYP 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  88 MYIAVF----IQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQ 163
Cdd:cd06178   74 LYAGSLlsynHVQNQGFVIFAGAILGIGAGLLWTAQGAIMLSYPTENQKGRFIAIFWVIFNLGGVIGSLIPFGLNYHSTS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 164 ISESDrrTVFIALTVISLVGTVLFFLIRKPDSENVlgedesSDDQDMEVNESAqnnlTKAVDAFKKSFKLCVTKEMLLLS 243
Cdd:cd06178  154 ATVND--ATYIAFIVLMAVGAVLALLLLDPPKVVR------KDGGRVAAIKSA----TWVSEELKLLLKLFKDPKMLLLF 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 244 I----TTAYTGLELTFFSGVYgtcigatnkFGAEEKSLIGLsgIFIGIgEILGGSLFGLLSKNNRFGRNPVVLLGILVHF 319
Cdd:cd06178  222 PaffaSNWFYTYQFNGVNGYL---------FNLRTRSLNNV--LYWGA-QMFGAYVIGYLLDAKFMSRRTRAFIGLAIVF 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 320 IAF--------YLIFLNMPGDA-PIAPVKGTDSSAYIksskeVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPA-FA 389
Cdd:cd06178  290 VIGmaiwggglAFQLSYTRDDVkPTPKIDDKTGRRYA-----GPFVLYLFYGILDAIYQTYVYWTMGALSNDPRKLArYA 364
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 335892870 390 -IFKFVQSICAAVAFF-------YSNYLLLHWQLLVMVIFGFFGTISFFT 431
Cdd:cd06178  365 gFYKGIQSAGAAIAWRldalkvsYMTQLIICWVLLAVGLPLASPVIYFYK 414
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
46-327 1.88e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 43.33  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  46 GSGYTSMAIIYGVFSASNLITPSVVAI----VGPQLSMFASGLFYSM-YIAVFIQPFPWSFYTASVFIGIAAAVLWTAQG 120
Cdd:cd17325   27 GASVAQIGLIVAAYALAQLLFSPPAGRlsdrFGRKRLLLLGLLLLAVsTLLFAFATSYWQLLLARFLQGLASAAVWPAAM 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 121 NCLTINSDEHSIGRNSGIFWALLQSSLFFGNL---YIYFAWqgktqisesDRRTVFIALTVISLVGTVLFFLIRKPDsen 197
Cdd:cd17325  107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLlggLLADAL---------GYRAPFLVCAALALLALVLALLLLPEP--- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 198 vlgedessddqdmevNESAQNNLTKAVDAFKKSFKLCVTKEMLLLSITTAYTGLELTFFSGVYGtcIGATNKFGAEEkSL 277
Cdd:cd17325  175 ---------------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLP--LYAAELGGLSP-AQ 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 335892870 278 IGLSGIFIGIGEILGGSLFGLLSknNRFGRNPVVLLGILVHFIAFYLIFL 327
Cdd:cd17325  237 IGLLFGAQGLASALSQPPAGKLS--DRIGRKPLILIGLLLSAVALLLLPL 284
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-402 4.06e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870   1 MSPESKKLFNIIILGVAFMFMFTAFQTCGNVAQTVIRslnrTDFHGSGYTS---MAIIYGVFSASNLITPSVVAIVGPQL 77
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA----ADLGASPAQAglvVTAYLLGAALGAPLAGRLADRFGRRR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870  78 SMFASGLFYS-MYIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYF 156
Cdd:COG2814   77 VLLLGLLLFAlGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 157 AwqgktqISESDRRTVFIALTVISLVGTVLFFLIrkpdsenvlgedessddqdmeVNESAQNNLTKAVDAFKKSFKLCVT 236
Cdd:COG2814  157 L------ADLFGWRWVFLVNAVLALLALLLLLRL---------------------LPESRPAARARLRGSLRELLRRPRL 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 237 KEMLLLSITTAYTGLELTFFSGVYgtcigATNKFGAEEkSLIGLSGIFIGIGEILGGSLFGLLSKnnRFGRNPVVLLGIL 316
Cdd:COG2814  210 LLLLLLAFLLGFGFFALFTYLPLY-----LQEVLGLSA-SAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLL 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335892870 317 VHFIAFYLIFLNmpgdapiapvkgtdssayikSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAP-AFAIFKFVQ 395
Cdd:COG2814  282 LLALGLLLLALA--------------------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGrASGLYNSAF 341

                 ....*..
gi 335892870 396 SICAAVA 402
Cdd:COG2814  342 FLGGPLA 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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