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Conserved domains on  [gi|341823689|ref|NP_001230065|]
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E3 ubiquitin-protein ligase pellino homolog 3 isoform 4 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase pellino family protein( domain architecture ID 10520238)

E3 ubiquitin-protein ligase pellino family protein which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins, and is involved in the TLR and IL-1 signaling pathways; similar to human E3 ubiquitin-protein ligase pellino homolog 1 (pellino-1)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 1-362 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


:

Pssm-ID: 461403  Cd Length: 409  Bit Score: 746.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689    1 MHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISR 79
Cdd:pfam04710  48 HHIVKTPQASKAILDKGQHSISYTLSRNQAVVVEYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISR 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689   80 YACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVY 159
Cdd:pfam04710 128 FACRILVDRNPPYTARIYAAGFDSSKNIFLGEKATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  160 TLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPAR 239
Cdd:pfam04710 208 SLRETRSAQQKGKLVENESNILQDGTLIDLCGATLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSR 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  240 GRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKT 319
Cdd:pfam04710 288 GRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGAR-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKT 366

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 341823689  320 ARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD 362
Cdd:pfam04710 367 VRYWSQIPLPHGTHAFHAACPFCATPLTGEPGYVKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 1-362 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 746.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689    1 MHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISR 79
Cdd:pfam04710  48 HHIVKTPQASKAILDKGQHSISYTLSRNQAVVVEYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISR 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689   80 YACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVY 159
Cdd:pfam04710 128 FACRILVDRNPPYTARIYAAGFDSSKNIFLGEKATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  160 TLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPAR 239
Cdd:pfam04710 208 SLRETRSAQQKGKLVENESNILQDGTLIDLCGATLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSR 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  240 GRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKT 319
Cdd:pfam04710 288 GRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGAR-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKT 366

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 341823689  320 ARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD 362
Cdd:pfam04710 367 VRYWSQIPLPHGTHAFHAACPFCATPLTGEPGYVKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 1-362 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 746.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689    1 MHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGG-AAEGPSAQSTISR 79
Cdd:pfam04710  48 HHIVKTPQASKAILDKGQHSISYTLSRNQAVVVEYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKtGEETQVAQSTISR 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689   80 YACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVY 159
Cdd:pfam04710 128 FACRILVDRNPPYTARIYAAGFDSSKNIFLGEKATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVY 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  160 TLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPAR 239
Cdd:pfam04710 208 SLRETRSAQQKGKLVENESNILQDGTLIDLCGATLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSR 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341823689  240 GRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQeRECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKT 319
Cdd:pfam04710 288 GRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGAR-RECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKT 366

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 341823689  320 ARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD 362
Cdd:pfam04710 367 VRYWSQIPLPHGTHAFHAACPFCATPLTGEPGYVKLIFQDNVD 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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