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Conserved domains on  [gi|342672053|ref|NP_001230154|]
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pescadillo homolog isoform 2 [Homo sapiens]

Protein Classification

Pescadillo_N and BRCT_pescadillo_like domain-containing protein( domain architecture ID 13419924)

Pescadillo_N and BRCT_pescadillo_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pescadillo_N pfam06732
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo ...
9-278 8.92e-165

Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.


:

Pssm-ID: 461996  Cd Length: 269  Bit Score: 469.80  E-value: 8.92e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053    9 YERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVF 88
Cdd:pfam06732   1 GKSGAAKNYITRNQALKKLQLSLKDFRRLCILKGIYPREPKKKKKANKGSTAPKTYYYTKDIKYLLHEPILEKFREYKAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   89 VRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEF 168
Cdd:pfam06732  81 AKKLKKALGKKEFERAKRLEKNKPKYKLDHIIKERYPTFIDALRDLDDALSMIFLFANLPSTDKIPANLIANCRRLTREF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  169 MHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPP 248
Cdd:pfam06732 161 QHYVIRSRSLRKVFVSIKGIYYQAEIKGQKITWLVPHKFTQRVPTDVDFRVMLTFLEFYETLLGFVNFKLYHSLNLKYPP 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 342672053  249 KLeGQAQAEAKAGEGTYALDSESCMEKLAA 278
Cdd:pfam06732 241 KL-DPRKDEKAAGLAALSLESKASTEELAA 269
NOP7 super family cl34924
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ...
6-579 2.91e-151

Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5163:

Pssm-ID: 227492 [Multi-domain]  Cd Length: 591  Bit Score: 447.60  E-value: 2.91e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   6 KKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREY 85
Cdd:COG5163    4 KGKNYIGPARKYITRGQAMKKLQLRLADFRRLCILKGVYPREPKNKKKANKGSTAPGTFYYIKDIQYLAHEPVYRKFREN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  86 KVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLT 165
Cdd:COG5163   84 KRFARKLKRALGTGEFEYAKRLEICDEEYGLDHIIKERYPGFGDAVDDIDDALSMLFLFSMLPLTDRISSKIANDAQEVC 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 166 VEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLH 245
Cdd:COG5163  164 EMFEDYVRRRSLLRKSFMSIKGVYYQATIGGEKVVWFVPYKFPENIPGDVDFRIMLTFLEFYSTLLHFVSLKLYVEEGLD 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 246 YPPKLEgQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTD---GEEDRRKELEAQEKH---- 318
Cdd:COG5163  244 YPPKFD-WSKPNFLDGLSSYELEESSSLPTEIEEDVKVESLDSSTLKSAVCNDPGNIDvskEELSEKIPELMVECRlvee 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 319 -------------------------KKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIV 373
Cdd:COG5163  323 kldtfednnknkdimemvskpcsslKSLFSGFKFYISREVPGDSLEFIILSCGGSVVGSPCEADIHVSEKVDEKVTHQIV 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 374 DRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVteKEGDYVPPEKLKLLALQRGEDPGNLNESE 453
Cdd:COG5163  403 DRPVMKNKVEGRTYIQPQWLFDSINKGKLACVENYCVGKRLPPHLSPFA--SVDSYDPRASLMTMEETQRHSEEDLVNRF 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 454 EEEEEDDNNEGDGDEEGENEEEEEDAeagsekEEEARLAALEEQRMEGKKPRvmagtlKLEDKQRLAQEEEsEAKRLAIM 533
Cdd:COG5163  481 EDVRYEHVAGEEDDDDDEELQAQKEL------ELEAQGIKYSETSEADKDVN------KSKNKKRKVDEEE-EEKKLKMI 547
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 342672053 534 MMKKREKYLYQKIMFGKRRKIREANKLAEKRKahDEAVRSEKKAKK 579
Cdd:COG5163  548 MMSNKQKKLYKKMKYSNAKKEEQAENLKKKKK--QIAKQKKLDSKK 591
 
Name Accession Description Interval E-value
Pescadillo_N pfam06732
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo ...
9-278 8.92e-165

Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.


Pssm-ID: 461996  Cd Length: 269  Bit Score: 469.80  E-value: 8.92e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053    9 YERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVF 88
Cdd:pfam06732   1 GKSGAAKNYITRNQALKKLQLSLKDFRRLCILKGIYPREPKKKKKANKGSTAPKTYYYTKDIKYLLHEPILEKFREYKAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   89 VRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEF 168
Cdd:pfam06732  81 AKKLKKALGKKEFERAKRLEKNKPKYKLDHIIKERYPTFIDALRDLDDALSMIFLFANLPSTDKIPANLIANCRRLTREF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  169 MHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPP 248
Cdd:pfam06732 161 QHYVIRSRSLRKVFVSIKGIYYQAEIKGQKITWLVPHKFTQRVPTDVDFRVMLTFLEFYETLLGFVNFKLYHSLNLKYPP 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 342672053  249 KLeGQAQAEAKAGEGTYALDSESCMEKLAA 278
Cdd:pfam06732 241 KL-DPRKDEKAAGLAALSLESKASTEELAA 269
NOP7 COG5163
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ...
6-579 2.91e-151

Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227492 [Multi-domain]  Cd Length: 591  Bit Score: 447.60  E-value: 2.91e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   6 KKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREY 85
Cdd:COG5163    4 KGKNYIGPARKYITRGQAMKKLQLRLADFRRLCILKGVYPREPKNKKKANKGSTAPGTFYYIKDIQYLAHEPVYRKFREN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  86 KVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLT 165
Cdd:COG5163   84 KRFARKLKRALGTGEFEYAKRLEICDEEYGLDHIIKERYPGFGDAVDDIDDALSMLFLFSMLPLTDRISSKIANDAQEVC 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 166 VEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLH 245
Cdd:COG5163  164 EMFEDYVRRRSLLRKSFMSIKGVYYQATIGGEKVVWFVPYKFPENIPGDVDFRIMLTFLEFYSTLLHFVSLKLYVEEGLD 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 246 YPPKLEgQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTD---GEEDRRKELEAQEKH---- 318
Cdd:COG5163  244 YPPKFD-WSKPNFLDGLSSYELEESSSLPTEIEEDVKVESLDSSTLKSAVCNDPGNIDvskEELSEKIPELMVECRlvee 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 319 -------------------------KKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIV 373
Cdd:COG5163  323 kldtfednnknkdimemvskpcsslKSLFSGFKFYISREVPGDSLEFIILSCGGSVVGSPCEADIHVSEKVDEKVTHQIV 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 374 DRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVteKEGDYVPPEKLKLLALQRGEDPGNLNESE 453
Cdd:COG5163  403 DRPVMKNKVEGRTYIQPQWLFDSINKGKLACVENYCVGKRLPPHLSPFA--SVDSYDPRASLMTMEETQRHSEEDLVNRF 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 454 EEEEEDDNNEGDGDEEGENEEEEEDAeagsekEEEARLAALEEQRMEGKKPRvmagtlKLEDKQRLAQEEEsEAKRLAIM 533
Cdd:COG5163  481 EDVRYEHVAGEEDDDDDEELQAQKEL------ELEAQGIKYSETSEADKDVN------KSKNKKRKVDEEE-EEKKLKMI 547
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 342672053 534 MMKKREKYLYQKIMFGKRRKIREANKLAEKRKahDEAVRSEKKAKK 579
Cdd:COG5163  548 MMSNKQKKLYKKMKYSNAKKEEQAENLKKKKK--QIAKQKKLDSKK 591
BRCT_pescadillo_like cd17709
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish ...
321-408 1.50e-54

BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish as a protein involved in the control of cell proliferation, specifically in the developing embryo. Mammalian homologs have been linked to ribosome biogenesis and nucleologenesis, and yeast homologs have been shown to be required for synthesis of the 60S ribosomal subunit. Pescadillo contains a BRCT domain.


Pssm-ID: 349341  Cd Length: 86  Bit Score: 179.31  E-value: 1.50e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 321 LFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGAtyDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNAR 400
Cdd:cd17709    1 LFKGLKFFLSREVPRESLEFIIRSFGGEVSWDGSDSPGA--DEDDESITHQIVDRPVQNKQYLSREYVQPQWVFDCVNAR 78

                 ....*...
gi 342672053 401 LLLPVAEY 408
Cdd:cd17709   79 ILLPVEDY 86
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
319-408 1.90e-08

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 51.60  E-value: 1.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  319 KKLFEGLKFFLNR--EVPREALAFIIRSFGGEVSwdkslcigatyDVTDSRITHQIVDRPGQQTSVIGRC--YVQPQWVF 394
Cdd:pfam16589   2 PNLFEPLRFYINAipSPSRSKLKRLIEANGGTVV-----------DNINPAVYIVIAPYNKTDKLAENTKlgVVSPQWIF 70
                          90
                  ....*....|....
gi 342672053  395 DSVNARLLLPVAEY 408
Cdd:pfam16589  71 DCVKKGKLLPLENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
320-397 1.90e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.53  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   320 KLFEGLKFFLNR---EVPREALAFIIRSFGGEVSWDkslcigatydVTDSRITHQIVDRPGQQTSVI------GRCYVQP 390
Cdd:smart00292   2 KLFKGKTFYITGsfdKEERDELKELIEALGGKVTSS----------LSSKTTTHVIVGSPEGGKLELlkaialGIPIVKE 71

                   ....*..
gi 342672053   391 QWVFDSV 397
Cdd:smart00292  72 EWLLDCL 78
PTZ00121 PTZ00121
MAEBL; Provisional
433-580 7.68e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  433 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLK 512
Cdd:PTZ00121 1562 EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKK 1641
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 342672053  513 LEDKQRLAQE---EESEAKRLAIMMMKKREKylyqkimfgKRRKIREANKLAE-KRKAHDEAVRSEKKAKKA 580
Cdd:PTZ00121 1642 EAEEKKKAEElkkAEEENKIKAAEEAKKAEE---------DKKKAEEAKKAEEdEKKAAEALKKEAEEAKKA 1704
 
Name Accession Description Interval E-value
Pescadillo_N pfam06732
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo ...
9-278 8.92e-165

Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.


Pssm-ID: 461996  Cd Length: 269  Bit Score: 469.80  E-value: 8.92e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053    9 YERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVF 88
Cdd:pfam06732   1 GKSGAAKNYITRNQALKKLQLSLKDFRRLCILKGIYPREPKKKKKANKGSTAPKTYYYTKDIKYLLHEPILEKFREYKAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   89 VRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEF 168
Cdd:pfam06732  81 AKKLKKALGKKEFERAKRLEKNKPKYKLDHIIKERYPTFIDALRDLDDALSMIFLFANLPSTDKIPANLIANCRRLTREF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  169 MHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPP 248
Cdd:pfam06732 161 QHYVIRSRSLRKVFVSIKGIYYQAEIKGQKITWLVPHKFTQRVPTDVDFRVMLTFLEFYETLLGFVNFKLYHSLNLKYPP 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 342672053  249 KLeGQAQAEAKAGEGTYALDSESCMEKLAA 278
Cdd:pfam06732 241 KL-DPRKDEKAAGLAALSLESKASTEELAA 269
NOP7 COG5163
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ...
6-579 2.91e-151

Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227492 [Multi-domain]  Cd Length: 591  Bit Score: 447.60  E-value: 2.91e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   6 KKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREY 85
Cdd:COG5163    4 KGKNYIGPARKYITRGQAMKKLQLRLADFRRLCILKGVYPREPKNKKKANKGSTAPGTFYYIKDIQYLAHEPVYRKFREN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  86 KVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLT 165
Cdd:COG5163   84 KRFARKLKRALGTGEFEYAKRLEICDEEYGLDHIIKERYPGFGDAVDDIDDALSMLFLFSMLPLTDRISSKIANDAQEVC 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 166 VEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLH 245
Cdd:COG5163  164 EMFEDYVRRRSLLRKSFMSIKGVYYQATIGGEKVVWFVPYKFPENIPGDVDFRIMLTFLEFYSTLLHFVSLKLYVEEGLD 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 246 YPPKLEgQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTD---GEEDRRKELEAQEKH---- 318
Cdd:COG5163  244 YPPKFD-WSKPNFLDGLSSYELEESSSLPTEIEEDVKVESLDSSTLKSAVCNDPGNIDvskEELSEKIPELMVECRlvee 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 319 -------------------------KKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIV 373
Cdd:COG5163  323 kldtfednnknkdimemvskpcsslKSLFSGFKFYISREVPGDSLEFIILSCGGSVVGSPCEADIHVSEKVDEKVTHQIV 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 374 DRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVteKEGDYVPPEKLKLLALQRGEDPGNLNESE 453
Cdd:COG5163  403 DRPVMKNKVEGRTYIQPQWLFDSINKGKLACVENYCVGKRLPPHLSPFA--SVDSYDPRASLMTMEETQRHSEEDLVNRF 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 454 EEEEEDDNNEGDGDEEGENEEEEEDAeagsekEEEARLAALEEQRMEGKKPRvmagtlKLEDKQRLAQEEEsEAKRLAIM 533
Cdd:COG5163  481 EDVRYEHVAGEEDDDDDEELQAQKEL------ELEAQGIKYSETSEADKDVN------KSKNKKRKVDEEE-EEKKLKMI 547
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*.
gi 342672053 534 MMKKREKYLYQKIMFGKRRKIREANKLAEKRKahDEAVRSEKKAKK 579
Cdd:COG5163  548 MMSNKQKKLYKKMKYSNAKKEEQAENLKKKKK--QIAKQKKLDSKK 591
BRCT_pescadillo_like cd17709
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish ...
321-408 1.50e-54

BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish as a protein involved in the control of cell proliferation, specifically in the developing embryo. Mammalian homologs have been linked to ribosome biogenesis and nucleologenesis, and yeast homologs have been shown to be required for synthesis of the 60S ribosomal subunit. Pescadillo contains a BRCT domain.


Pssm-ID: 349341  Cd Length: 86  Bit Score: 179.31  E-value: 1.50e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 321 LFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGAtyDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNAR 400
Cdd:cd17709    1 LFKGLKFFLSREVPRESLEFIIRSFGGEVSWDGSDSPGA--DEDDESITHQIVDRPVQNKQYLSREYVQPQWVFDCVNAR 78

                 ....*...
gi 342672053 401 LLLPVAEY 408
Cdd:cd17709   79 ILLPVEDY 86
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
319-408 1.90e-08

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 51.60  E-value: 1.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  319 KKLFEGLKFFLNR--EVPREALAFIIRSFGGEVSwdkslcigatyDVTDSRITHQIVDRPGQQTSVIGRC--YVQPQWVF 394
Cdd:pfam16589   2 PNLFEPLRFYINAipSPSRSKLKRLIEANGGTVV-----------DNINPAVYIVIAPYNKTDKLAENTKlgVVSPQWIF 70
                          90
                  ....*....|....
gi 342672053  395 DSVNARLLLPVAEY 408
Cdd:pfam16589  71 DCVKKGKLLPLENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
320-397 1.90e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.53  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053   320 KLFEGLKFFLNR---EVPREALAFIIRSFGGEVSWDkslcigatydVTDSRITHQIVDRPGQQTSVI------GRCYVQP 390
Cdd:smart00292   2 KLFKGKTFYITGsfdKEERDELKELIEALGGKVTSS----------LSSKTTTHVIVGSPEGGKLELlkaialGIPIVKE 71

                   ....*..
gi 342672053   391 QWVFDSV 397
Cdd:smart00292  72 EWLLDCL 78
PTZ00121 PTZ00121
MAEBL; Provisional
433-580 7.68e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  433 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLK 512
Cdd:PTZ00121 1562 EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKK 1641
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 342672053  513 LEDKQRLAQE---EESEAKRLAIMMMKKREKylyqkimfgKRRKIREANKLAE-KRKAHDEAVRSEKKAKKA 580
Cdd:PTZ00121 1642 EAEEKKKAEElkkAEEENKIKAAEEAKKAEE---------DKKKAEEAKKAEEdEKKAAEALKKEAEEAKKA 1704
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
335-396 2.83e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 36.57  E-value: 2.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 342672053 335 REALAFIIRSFGGEVSWDKSlcigatydvtdSRITHQIVDRPGQQTSVI-----GRCYVQPQWVFDS 396
Cdd:cd00027   13 REELKKLIEALGGKVSESLS-----------SKVTHLIAKSPSGEKYYLaalawGIPIVSPEWLLDC 68
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
321-409 3.93e-03

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 36.78  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053 321 LFEGLKFFLN--REVPREALAFIIRSFGGEVSwdkslcigaTYdVTDSRITHQIVDR-PGQQTSVIGR----CYVQPQWV 393
Cdd:cd17719    1 IFKGVVIYVNgyTDPSADELKRLILLHGGQYE---------HY-YSRSRVTHIIATNlPGSKIKKLKKarnyKVVRPEWI 70
                         90
                 ....*....|....*.
gi 342672053 394 FDSVNARLLLPVAEYF 409
Cdd:cd17719   71 VDSIKAGRLLPEAPYL 86
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
320-397 5.21e-03

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 36.12  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342672053  320 KLFEGLKFFLNR--EVPREALAFIIRSFGGEVSwdKSLCIGATYDVTDSRIT-HQIVDRPGqqtsviGRCyVQPQWVFDS 396
Cdd:pfam00533   4 KLFSGKTFVITGldGLERDELKELIEKLGGKVT--DSLSKKTTHVIVEARTKkYLKAKELG------IPI-VTEEWLLDC 74

                  .
gi 342672053  397 V 397
Cdd:pfam00533  75 I 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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