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Conserved domains on  [gi|346644667|ref|NP_001231121|]
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protein TALPID3 isoform 4 [Homo sapiens]

Protein Classification

TALPID3 domain-containing protein( domain architecture ID 12173090)

TALPID3 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 31-1313 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


:

Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1928.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667    31 DIFISQYTMGQKDALRTVLKQnvslcltgwsdhsgvitthcslyllrlmrsshlslpsswdyRAQSMPVFKEVKVHLLED 110
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQ-----------------------------------------RAQSAPVFKEVKVQLLDD 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   111 AGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRK 190
Cdd:pfam15324   40 ACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAK 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   191 QEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSL 268
Cdd:pfam15324  120 QEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSH 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   269 YnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSL 348
Cdd:pfam15324  200 H-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSP 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   349 TRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETNSMV----------- 409
Cdd:pfam15324  279 TRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpna 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   410 ------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAII 465
Cdd:pfam15324  359 kstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAII 438

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   466 RAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KD 537
Cdd:pfam15324  439 RAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKD 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   538 IRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKK 617
Cdd:pfam15324  519 IKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKK 596

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   618 GPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLE 697
Cdd:pfam15324  597 GPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLE 675

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   698 GHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDI 777
Cdd:pfam15324  676 GHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDI 755

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   778 DSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRS 854
Cdd:pfam15324  756 DSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRS 835

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   855 VKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLT 934
Cdd:pfam15324  836 VKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPST 915

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   935 SDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTP 1014
Cdd:pfam15324  916 SDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTP 991

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1015 QPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDIS 1093
Cdd:pfam15324  992 QPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENS 1069

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1094 IDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQ 1173
Cdd:pfam15324 1070 IDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQ 1147

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1174 MPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVI 1253
Cdd:pfam15324 1148 SPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVI 1227

                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 346644667  1254 RMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1313
Cdd:pfam15324 1228 RRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 31-1313 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1928.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667    31 DIFISQYTMGQKDALRTVLKQnvslcltgwsdhsgvitthcslyllrlmrsshlslpsswdyRAQSMPVFKEVKVHLLED 110
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQ-----------------------------------------RAQSAPVFKEVKVQLLDD 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   111 AGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRK 190
Cdd:pfam15324   40 ACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAK 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   191 QEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSL 268
Cdd:pfam15324  120 QEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSH 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   269 YnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSL 348
Cdd:pfam15324  200 H-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSP 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   349 TRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETNSMV----------- 409
Cdd:pfam15324  279 TRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpna 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   410 ------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAII 465
Cdd:pfam15324  359 kstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAII 438

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   466 RAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KD 537
Cdd:pfam15324  439 RAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKD 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   538 IRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKK 617
Cdd:pfam15324  519 IKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKK 596

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   618 GPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLE 697
Cdd:pfam15324  597 GPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLE 675

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   698 GHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDI 777
Cdd:pfam15324  676 GHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDI 755

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   778 DSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRS 854
Cdd:pfam15324  756 DSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRS 835

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   855 VKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLT 934
Cdd:pfam15324  836 VKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPST 915

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   935 SDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTP 1014
Cdd:pfam15324  916 SDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTP 991

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1015 QPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDIS 1093
Cdd:pfam15324  992 QPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENS 1069

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1094 IDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQ 1173
Cdd:pfam15324 1070 IDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQ 1147

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1174 MPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVI 1253
Cdd:pfam15324 1148 SPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVI 1227

                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 346644667  1254 RMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1313
Cdd:pfam15324 1228 RRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 31-1313 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1928.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667    31 DIFISQYTMGQKDALRTVLKQnvslcltgwsdhsgvitthcslyllrlmrsshlslpsswdyRAQSMPVFKEVKVHLLED 110
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQ-----------------------------------------RAQSAPVFKEVKVQLLDD 39

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   111 AGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRK 190
Cdd:pfam15324   40 ACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIKVQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAK 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   191 QEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSL 268
Cdd:pfam15324  120 QEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGSALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSH 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   269 YnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSL 348
Cdd:pfam15324  200 H-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSRDAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSP 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   349 TRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEELETTKVTMQKSDDVLHDLGQKEKETNSMV----------- 409
Cdd:pfam15324  279 TRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEPETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpna 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   410 ------QPKESLSMLKLPDLP------------------QNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAII 465
Cdd:pfam15324  359 kstrssQSSRSLSPLPTPPPPppapismppvtavslaalSSPSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAII 438

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   466 RAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KD 537
Cdd:pfam15324  439 RAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKEIQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKD 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   538 IRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKK 617
Cdd:pfam15324  519 IKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSLQK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKK 596

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   618 GPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLE 697
Cdd:pfam15324  597 GPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHATKPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLE 675

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   698 GHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDI 777
Cdd:pfam15324  676 GHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPPSSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDI 755

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   778 DSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRS 854
Cdd:pfam15324  756 DSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDEEEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRS 835

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   855 VKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLT 934
Cdd:pfam15324  836 VKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRLVDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPST 915

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667   935 SDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTP 1014
Cdd:pfam15324  916 SDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAIMLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTP 991

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1015 QPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICAEKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDIS 1093
Cdd:pfam15324  992 QPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPPEKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENS 1069

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1094 IDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQ 1173
Cdd:pfam15324 1070 IDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVMSVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQ 1147

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346644667  1174 MPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVI 1253
Cdd:pfam15324 1148 SPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLAVRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVI 1227

                         1290      1300      1310      1320      1330      1340
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 346644667  1254 RMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMG 1313
Cdd:pfam15324 1228 RRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVGELSEGQRPRLTAAAENVLTG 1288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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