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Conserved domains on  [gi|347659013|ref|NP_001231630|]
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mRNA decay activator protein ZFP36L1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 70-175 2.66e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


:

Pssm-ID: 461350  Cd Length: 114  Bit Score: 141.92  E-value: 2.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347659013   70 MTTTLVSAtIFDLsEVLCKGNKMLNysaPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 146
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 347659013  147 ALSS---------RDSRFRDRSFSEGGERLLPTQKQPG 175
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQ 113
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
184-246 9.48e-13

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.93  E-value: 9.48e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 347659013 184 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 246
Cdd:COG5063  113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 70-175 2.66e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 141.92  E-value: 2.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347659013   70 MTTTLVSAtIFDLsEVLCKGNKMLNysaPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 146
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 347659013  147 ALSS---------RDSRFRDRSFSEGGERLLPTQKQPG 175
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQ 113
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
184-246 9.48e-13

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.93  E-value: 9.48e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 347659013 184 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 246
Cdd:COG5063  113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
184-209 1.45e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 52.97  E-value: 1.45e-09
                          10        20
                  ....*....|....*....|....*.
gi 347659013  184 YKTELCRPFEENGACKYGDKCQFAHG 209
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
183-209 2.03e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 46.85  E-value: 2.03e-07
                           10        20
                   ....*....|....*....|....*..
gi 347659013   183 RYKTELCRPFEeNGACKYGDKCQFAHG 209
Cdd:smart00356   1 KYKTELCKFFK-RGYCPRGDRCKFAHP 26
COG5152 COG5152
Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function ...
 140-208 1.53e-04

Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only];


Pssm-ID: 227481 [Multi-domain]  Cd Length: 259  Bit Score: 43.14  E-value: 1.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347659013 140 LKGEPAPALS--SRDSRFRD-----RSFSEGGERLLPTQKQPGGGQVNS-SRYKTELCRPFEENGACKYGDKCQFAH 208
Cdd:COG5152   87 LLNFERKELAekAKKRRPSDdnelvLNMSGKNKRLTKQINQPTMFRDGEvIDTQPDVCKDYKETGYCGYGDSCKFLH 163
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 70-175 2.66e-41

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 141.92  E-value: 2.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347659013   70 MTTTLVSAtIFDLsEVLCKGNKMLNysaPSAGGC-LLDRKAVGTPAG--GGFPRRHSVTLPSSKFHQNQLLSSLKGEPAP 146
Cdd:pfam04553   1 MSTTLVSA-FFDF-DVLCKNNKSLN---SNPTGLnLLDRKAVGTPVTgsGVFQRRHSVSNLSAKFNQNQFLKELKAEPSS 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 347659013  147 ALSS---------RDSRFRDRSFSEGGERLLPTQKQPG 175
Cdd:pfam04553  76 LISGsggttallnKENKFRDRSFSENGERLLHLQKLQQ 113
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
184-246 9.48e-13

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.93  E-value: 9.48e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 347659013 184 YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 246
Cdd:COG5063  113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
175-246 3.81e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 60.84  E-value: 3.81e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347659013 175 GGGQVNSSR--YKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHP--KYKTELCRTFHTIGFCPYGPRCHFIH 246
Cdd:COG5063  261 NELKSKKKKqnFRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSF 336
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
166-250 4.64e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 60.84  E-value: 4.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347659013 166 RLLPTQKQpgggQVNSSRYKT--ELCRPFEENGACKY---GDKCQFA---HGIHELRSLTRHPKYKTELCRTFHTIGFCP 237
Cdd:COG5063  212 DELIYQKQ----EQNKPLYKTnpELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCP 287

                         90
                 ....*....|...
gi 347659013 238 YGPRCHFIHNAEE 250
Cdd:COG5063  288 YGLRCCFKHGDDS 300
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
184-209 1.45e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 52.97  E-value: 1.45e-09
                          10        20
                  ....*....|....*....|....*.
gi 347659013  184 YKTELCRPFEENGACKYGDKCQFAHG 209
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHG 26
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
222-246 7.35e-09

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 50.65  E-value: 7.35e-09
                          10        20
                  ....*....|....*....|....*
gi 347659013  222 YKTELCRTFHTIGFCPYGPRCHFIH 246
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
183-209 2.03e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 46.85  E-value: 2.03e-07
                           10        20
                   ....*....|....*....|....*..
gi 347659013   183 RYKTELCRPFEeNGACKYGDKCQFAHG 209
Cdd:smart00356   1 KYKTELCKFFK-RGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
221-247 2.26e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 46.47  E-value: 2.26e-07
                           10        20
                   ....*....|....*....|....*..
gi 347659013   221 KYKTELCRTFHTiGFCPYGPRCHFIHN 247
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHP 26
COG5152 COG5152
Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function ...
 140-208 1.53e-04

Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only];


Pssm-ID: 227481 [Multi-domain]  Cd Length: 259  Bit Score: 43.14  E-value: 1.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347659013 140 LKGEPAPALS--SRDSRFRD-----RSFSEGGERLLPTQKQPGGGQVNS-SRYKTELCRPFEENGACKYGDKCQFAH 208
Cdd:COG5152   87 LLNFERKELAekAKKRRPSDdnelvLNMSGKNKRLTKQINQPTMFRDGEvIDTQPDVCKDYKETGYCGYGDSCKFLH 163
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 189-208 5.62e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.01  E-value: 5.62e-04
                          10        20
                  ....*....|....*....|
gi 347659013  189 CRPFEeNGACKYGDKCQFAH 208
Cdd:pfam18345   1 CKFFL-KGRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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