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Conserved domains on  [gi|357197147|ref|NP_001239401|]
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SLAM family member 5 isoform 2 precursor [Mus musculus]

Protein Classification

Ig_SLAM-CD84_like_N domain-containing protein( domain architecture ID 11617245)

Ig_SLAM-CD84_like_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 1.43e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 120.89  E-value: 1.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 357197147 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 1.43e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 120.89  E-value: 1.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 357197147 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-126 3.29e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 3.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147   26 PVVMNGILGESVTFL--LNIQEPKKIDNIAWTSQSSVA----FIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRM 99
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWYRQPPGKgptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 357197147  100 EDAGTYKADINEENEETITKIYYLHIY 126
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 1.43e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 120.89  E-value: 1.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 357197147 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 29-126 2.78e-08

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 48.50  E-value: 2.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  29 MNGILGESVTflLNIQE-PKKIDNIAW--TSQSSVAFikpgVNKAEVTITqGTYKGRIEIIDQKYDLVIRDLRMEDAGTY 105
Cdd:cd05775    5 VYGALGGNVT--LTISSlQDDIDEIKWkkTKDKIVEW----ENNIGPTYF-GSFKDRVLLDKESGSLTIKNLTKEDSGTY 77

                         90       100
                 ....*....|....*....|.
gi 357197147 106 KADINEENEETITKIYYLHIY 126
Cdd:cd05775   78 ELEITSTNGKVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-126 3.29e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 3.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147   26 PVVMNGILGESVTFL--LNIQEPKKIDNIAWTSQSSVA----FIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRM 99
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWYRQPPGKgptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 357197147  100 EDAGTYKADINEENEETITKIYYLHIY 126
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 76-114 1.63e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 35.59  E-value: 1.63e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 357197147  76 QGTYKGRIEIIDqkYDLVIRDLRMEDAGTYKADINEENE 114
Cdd:cd20946   52 QGDYKGRAEILG--TNITIKNVTRSDSGKYRCEVSARSD 88
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 30-125 2.08e-03

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 35.57  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  30 NGILGESVTFLL-NIQEPKKidNIAWTSQSSVAF---IKPGVNKAEVTITQGTYKGRiEIIDQKYDLVIRDLRMEDAGTY 105
Cdd:cd05741    6 YGAEGKNVLLLVpNLQTPLK--SVSWYKGKQVSRndeIAEYENSSDEFRAGSAFSGR-EYIYTNGSLLIQNITLSDTGFY 82

                         90       100
                 ....*....|....*....|
gi 357197147 106 KADINEENEETITKIYYLHI 125
Cdd:cd05741   83 TLESTNIGGKTESATFQLHV 102
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 29-105 2.63e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 35.50  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  29 MNGILGESVTF--LLNIQEPKKIDNIAW-----TSQSSVAFIKP--GVNkaevtiTQGTYKGRIEIIDQKYD-----LVI 94
Cdd:cd05718    9 VTGFLGGSVTLpcSLTSPGTTKITQVTWmkigaGSSQNVAVFHPqyGPS------VPNPYAERVEFLAARLGlrnatLRI 82

                         90
                 ....*....|.
gi 357197147  95 RDLRMEDAGTY 105
Cdd:cd05718   83 RNLRVEDEGNY 93
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 25-118 7.13e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 33.91  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197147  25 DPVVMNGILGESVTFLLNIQEpkkidniaWTSQSSVAFIKPGVNKAEVTITQGTY--KGRIEIIDQKYDLV----IRDLR 98
Cdd:cd05716    3 GPEVVTGVEGGSVTIQCPYPP--------KYASSRKYWCKWGSEGCQTLVSSEGVvpGGRISLTDDPDNGVftvtLNQLR 74

                         90       100
                 ....*....|....*....|..
gi 357197147  99 MEDAGTYK--ADINEENEETIT 118
Cdd:cd05716   75 KEDAGWYWcgVGDDGDRGLTVQ 96
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 82-115 8.23e-03

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 33.68  E-value: 8.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 357197147  82 RIEIIDQ-KYDLVIRDLRMEDAGTYKADINEENEE 115
Cdd:cd07690   58 RRNLWDQgSFPLIIKNLKIEDSDTYICEVEDKKEE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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