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Conserved domains on  [gi|357588422|ref|NP_001239496|]
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seizure 6-like protein 2 isoform 3 precursor [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 12869279)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 467-557 1.76e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 467 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 540
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588422 541 PRRRLLSSGPDLTLQFQ 557
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 605-768 3.15e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.39  E-value: 3.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 680
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 681 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 759
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588422 760 QWTSQPPLC 768
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 289-357 4.69e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 4.69e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422 289 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 357
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 113-225 1.00e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 113 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 186
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588422 187 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 225
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 230-285 7.32e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422 230 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 285
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
406-463 4.04e-06

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422  406 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 463
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 467-557 1.76e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 467 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 540
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588422 541 PRRRLLSSGPDLTLQFQ 557
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 605-768 3.15e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.39  E-value: 3.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 680
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 681 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 759
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588422 760 QWTSQPPLC 768
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 289-357 4.69e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 4.69e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422 289 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 357
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 584-640 4.60e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.71  E-value: 4.60e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357588422 584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 640
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 113-225 1.00e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 113 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 186
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588422 187 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 225
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 584-639 1.46e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 1.46e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588422   584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 639
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB pfam00431
CUB domain;
467-557 1.81e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.54  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422  467 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 541
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 357588422  542 RRRLLSSGPDLTLQFQ 557
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 476-557 2.72e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.87  E-value: 2.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422   476 GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 549
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 357588422   550 PDLTLQFQ 557
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
584-639 6.95e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 6.95e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588422  584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 639
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 230-285 7.32e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422 230 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 285
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 230-285 1.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 1.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422   230 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTRpaWTGEPPSC 285
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
230-285 8.16e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.50  E-value: 8.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422  230 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 285
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQeDGT---WSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 299-357 1.74e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 50.08  E-value: 1.74e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422   299 GRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 357
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
406-463 4.04e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422  406 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 463
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 405-464 2.17e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 2.17e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 405 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 464
Cdd:cd00033    3 PPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 122-223 4.42e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.15  E-value: 4.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422   122 GFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAG--GGSPGLApRLLANSSMlgeG 194
Cdd:smart00042   1 GTITSPNYPQSYPNN---LDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDGpsASSPLLG-RFCGSEAP---P 73

                           90       100
                   ....*....|....*....|....*....
gi 357588422   195 QVLRSPTNRLLLHFQSPRVPRGNGFRIHY 223
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
289-357 6.18e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 6.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422  289 CGGTIHNATlGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 357
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 405-463 7.41e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 7.41e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422   405 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 463
Cdd:smart00032   3 PPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
CUB pfam00431
CUB domain;
141-223 3.49e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422  141 DCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllANSSMLGE------GQVLRSPTNRLLLHFQ 209
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------ASSPLLGRfcgsgiPEDIVSSSNQMTIKFV 96

                          90
                  ....*....|....
gi 357588422  210 SPRVPRGNGFRIHY 223
Cdd:pfam00431  97 SDASVQKRGFKATY 110
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 467-557 1.76e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.77  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 467 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 540
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 357588422 541 PRRRLLSSGPDLTLQFQ 557
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 605-768 3.15e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 82.39  E-value: 3.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLE 680
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 681 GAAVLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 759
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 357588422 760 QWTSQPPLC 768
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 289-357 4.69e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.06  E-value: 4.69e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422 289 CGGTIHNATLGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 357
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 605-770 7.71e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 69.68  E-value: 7.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGY--ELLGSDILTCQWDlSWSAAPPACQKimTCADPGEITNGHRTASDAGFpvGSHVQYRCLPGYSLEGA 682
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTGT-GWTLFNQCIKR--RCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 683 AVLTCYSRDTGTPKWSDRVPKCalKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpsQWt 762
Cdd:PHA02927 122 SKSYCELGSTGSMVWNPEAPIC--ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG---EW- 195


                 ....*...
gi 357588422 763 SQPPLCKV 770
Cdd:PHA02927 196 SDPPTCQI 203
PHA02639 PHA02639
EEV host range protein; Provisional
 641-770 2.02e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 68.92  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 641 KIMTCADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCYsRDTGTPKWSDRVPKCALKyePCLNPGVPENG 720
Cdd:PHA02639  18 KSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLK--ECNDPPSIING 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 357588422 721 YQTLYKHHYQAGESLRFFCYE----GFELIGEVTITCVpgHPSQWTSQPPLCKV 770
Cdd:PHA02639  95 KIYNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI--QDKSWKPDPPICKM 146
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 584-640 4.60e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.71  E-value: 4.60e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357588422 584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 640
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 711-769 6.61e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 6.61e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422 711 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLCK 769
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 113-225 1.00e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.43  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 113 CNNNIS-EGEGFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 186
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNN---LNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 357588422 187 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGNGFRIHYQA 225
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 584-639 1.46e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 1.46e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588422   584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 639
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB pfam00431
CUB domain;
467-557 1.81e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.54  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422  467 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 541
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 357588422  542 RRRLLSSGPDLTLQFQ 557
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 476-557 2.72e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.87  E-value: 2.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422   476 GVVLSPDWPQSYSPGQDCVWGLHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 549
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 357588422   550 PDLTLQFQ 557
Cdd:smart00042  81 NSLTLTFV 88
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 645-704 4.66e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.69  E-value: 4.66e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422   645 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 704
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITC----LENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
584-639 6.95e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 6.95e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357588422  584 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 639
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 645-704 7.18e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.18e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 645 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 704
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC----TENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 230-285 7.32e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422 230 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 285
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 711-768 8.89e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.92  E-value: 8.89e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422   711 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 768
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 230-285 1.30e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 1.30e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422   230 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTRpaWTGEPPSC 285
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 608-768 7.62e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 60.78  E-value: 7.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 608 LTYQCEPGYEllgSDILTCQwDLSWSAAPpACQKIMTCADPGEITNGHRTASDAGFPVGSHVQYRC----LPGYSLEGAA 683
Cdd:PHA02831  46 LEYKCNNNFD---KVFVTCN-NGSWSTKN-MCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 684 VLTCYSRdtgtpKWSDRVPKCAL---KYePCLnpgvpENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCvpGHPSQ 760
Cdd:PHA02831 121 TVKCINK-----QWVPKYPVCKLircKY-PAL-----QNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSI 187


                 ....*...
gi 357588422 761 WTSQPPLC 768
Cdd:PHA02831 188 WYPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 605-768 9.40e-10

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 60.83  E-value: 9.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPACQkIMTCADPGEITNGHRTASDAGFPVGSHVQYRCLP----GY 677
Cdd:PHA02639  43 GKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCM-LKECNDPPSIINGKIYNKREMYKVGDEIYYVCNEhkgvQY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 678 SLEGAAVLTCysrdTGTPKWSDRVPKCalKYEPCLNPGVPE---NGYQTLYKHHYQAgeSLRFFCYEGFELIGEVTITCv 754
Cdd:PHA02639 122 SLVGNEKITC----IQDKSWKPDPPIC--KMINCRFPALQNgyiNGIPSNKKFYYKT--RVGFSCKSGFDLVGEKYSTC- 192

                        170
                 ....*....|....
gi 357588422 755 pGHPSQWTSQPPLC 768
Cdd:PHA02639 193 -NINATWFPSIPTC 205
Sushi pfam00084
Sushi repeat (SCR repeat);
645-704 2.33e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 54.04  E-value: 2.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422  645 CADPGEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCysrdTGTPKWSDRVPKC 704
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITC----QEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
230-285 8.16e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.50  E-value: 8.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422  230 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICL-NGTrpaWTGEPPSC 285
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQeDGT---WSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 299-357 1.74e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 50.08  E-value: 1.74e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422   299 GRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 357
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
711-768 4.07e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422  711 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 768
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
406-463 4.04e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 4.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357588422  406 PPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 463
Cdd:pfam00084   4 PPDIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 604-713 9.91e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 47.63  E-value: 9.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 604 RGTVLTYQCEPG-----YELLGSDILTCQWDLSWSAAPPACqKIMTCADPGeITNGHRTA--SDAGFPVGSHVQYRCLPG 676
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVC-KIIRCRFPA-LQNGFVNGipDSKKFYYESEVSFSCKPG 121

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 357588422 677 YSLEGAAVLTCYSRDTgtpkWSDRVPKCaLKYEPCLN 713
Cdd:PHA02817 122 FVLIGTKYSVCGINSS----WIPKVPIC-SRDNITYN 153
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 405-464 2.17e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 2.17e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 405 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 464
Cdd:cd00033    3 PPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 645-819 2.33e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.47  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 645 CADPGEITNGHRTASDAGFPVGSHVQYRC------LPgYSLEGAAVLTCySRDTgtpKWSDRVPKCAL---KYePCLNPG 715
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCgnntrgVR-YTLVGEKNIIC-EKDG---KWNKEFPVCKIircRF-PALQNG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 716 VPeNGYQTLYKHHYQagESLRFFCYEGFELIGEVTITCvpGHPSQWTSQPPLC--------KVAYEELL--DNRKLEVTQ 785
Cdd:PHA02817  98 FV-NGIPDSKKFYYE--SEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPICsrdnitynKIYINKVNidDNFFNQINN 172

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 357588422 786 TTDPS--RQLEGGNLA---LAILLPLGLVIVLGIGVYIY 819
Cdd:PHA02817 173 SNTYYfdKILQINNVNrytLIFFVVVSIKILFGFVFIFF 211
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 122-223 4.42e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 43.15  E-value: 4.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422   122 GFVESPDLGSTASRSvelLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAG--GGSPGLApRLLANSSMlgeG 194
Cdd:smart00042   1 GTITSPNYPQSYPNN---LDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDGpsASSPLLG-RFCGSEAP---P 73

                           90       100
                   ....*....|....*....|....*....
gi 357588422   195 QVLRSPTNRLLLHFQSPRVPRGNGFRIHY 223
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 653-769 5.35e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 45.80  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 653 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLtcYSRDTGTpKWSdRVPKCALKYepCLNPGVPENGYQTLYKHHYqaG 732
Cdd:PHA02927  34 NSVETDANANYNIGDTIEYLCLPGYRKQKMGPI--YAKCTGT-GWT-LFNQCIKRR--CPSPRDIDNGQLDIGGVDF--G 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 357588422 733 ESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPPLCK 769
Cdd:PHA02927 106 SSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPICE 144
CUB pfam00431
CUB domain;
289-357 6.18e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 6.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588422  289 CGGTIHNATlGRIVSPEPGGAAGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 357
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 605-704 6.63e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 45.85  E-value: 6.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 605 GTVLTYQCEPGYELLGSDILTCQWDlSWSAAPPACQKimtCADPgEITNGhrTASDAGFPVGSHVQYRCLPGYSLEGAAV 684
Cdd:PHA02954 150 GEHITINCDVGYEVIGASYISCTAN-SWNVIPSCQQK---CDIP-SLSNG--LISGSTFSIGGVIHLSCKSGFTLTGSPS 222

                         90       100
                 ....*....|....*....|
gi 357588422 685 LTCYSrdtgtPKWSDRVPKC 704
Cdd:PHA02954 223 STCID-----GKWNPVLPIC 237
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 405-463 7.41e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 7.41e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 357588422   405 FPPFLAHGNVTTTDPEFHPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 463
Cdd:smart00032   3 PPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 704-770 2.05e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.69  E-value: 2.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357588422 704 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEG-----FELIGEVTITCvpGHPSQWTSQPPLCKV 770
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC--EKDGKWNKEFPVCKI 86
CUB pfam00431
CUB domain;
141-223 3.49e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.04  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422  141 DCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllANSSMLGE------GQVLRSPTNRLLLHFQ 209
Cdd:pfam00431  26 DCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------ASSPLLGRfcgsgiPEDIVSSSNQMTIKFV 96

                          90
                  ....*....|....
gi 357588422  210 SPRVPRGNGFRIHY 223
Cdd:pfam00431  97 SDASVQKRGFKATY 110
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 663-775 8.84e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 39.30  E-value: 8.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588422 663 FPVGSHVQYRCLPGYSLEGAAVLTCYSRdtgtpKWsDRVPKCALKYE-PCLNPGVpengyqtLYKHHYQAGESLRFFCYE 741
Cdd:PHA02954 147 YSFGEHITINCDVGYEVIGASYISCTAN-----SW-NVIPSCQQKCDiPSLSNGL-------ISGSTFSIGGVIHLSCKS 213

                         90       100       110
                 ....*....|....*....|....*....|....
gi 357588422 742 GFELIGEVTITCVPGhpsQWTSQPPLCKVAYEEL 775
Cdd:PHA02954 214 GFTLTGSPSSTCIDG---KWNPVLPICVRSNEEF 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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