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Conserved domains on  [gi|359279863|ref|NP_001240654|]
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kremen protein 2 isoform e precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 34-119 4.40e-21

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


:

Pssm-ID: 214527  Cd Length: 83  Bit Score: 86.29  E-value: 4.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863    34 SECFQVNGADYRGHQNRTGPrgaGRPCLFWDQTQQHSYSSASDPHGRWGLGaHNFCRNPDGDV-QPWCYVaeTEEGIYWR 112
Cdd:smart00130   1 RECYAGNGESYRGTVSVTKS---GKPCQRWDSQTPHLHRFTPESFPDLGLE-ENYCRNPDGDSeGPWCYT--TDPNVRWE 74


                   ....*..
gi 359279863   113 YCDIPSC 119
Cdd:smart00130  75 YCDIPQC 81
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 180-285 2.34e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 2.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863 180 CQGNWTAP-QGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRD--AASGSLLRAFDGAR 251
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIeAPPGYRIRLTFEDFDLESSPncsyDYLEIYDgpSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 359279863 252 PPPsgPLRLGTAALLLTFRSDARGHAQGFALTYR 285
Cdd:cd00041   81 LPP--PIISSGNSLTVRFRSDSSVTGRGFKATYS 112
WSC super family cl47698
WSC domain; This domain is involved in carbohydrate binding.
 124-165 6.51e-07

WSC domain; This domain is involved in carbohydrate binding.


The actual alignment was detected with superfamily member pfam01822:

Pssm-ID: 460348  Cd Length: 82  Bit Score: 46.68  E-value: 6.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 359279863  124 YLGCFVDSGAPPALSGP-SGTSTKLTVQVCLRFCRMKGYQLCG 165
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGsSGDYDDMTPEKCIAFCSAAGYTYAG 43
 
Name Accession Description Interval E-value
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 34-119 4.40e-21

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 86.29  E-value: 4.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863    34 SECFQVNGADYRGHQNRTGPrgaGRPCLFWDQTQQHSYSSASDPHGRWGLGaHNFCRNPDGDV-QPWCYVaeTEEGIYWR 112
Cdd:smart00130   1 RECYAGNGESYRGTVSVTKS---GKPCQRWDSQTPHLHRFTPESFPDLGLE-ENYCRNPDGDSeGPWCYT--TDPNVRWE 74


                   ....*..
gi 359279863   113 YCDIPSC 119
Cdd:smart00130  75 YCDIPQC 81
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 35-119 4.62e-21

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 86.28  E-value: 4.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863  35 ECFQVNGADYRGHQNRTGPrgaGRPCLFWD--QTQQHSYSSASDPHGrwgLGAHNFCRNPDGDV-QPWCYVaeTEEGIYW 111
Cdd:cd00108    3 DCYWGNGESYRGTVSTTKS---GKPCQRWNsqLPHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYT--TDPNVRW 74


                 ....*...
gi 359279863 112 RYCDIPSC 119
Cdd:cd00108   75 EYCDIPRC 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 180-285 2.34e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 2.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863 180 CQGNWTAP-QGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRD--AASGSLLRAFDGAR 251
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIeAPPGYRIRLTFEDFDLESSPncsyDYLEIYDgpSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 359279863 252 PPPsgPLRLGTAALLLTFRSDARGHAQGFALTYR 285
Cdd:cd00041   81 LPP--PIISSGNSLTVRFRSDSSVTGRGFKATYS 112
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 36-119 1.91e-17

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 76.19  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863   36 CFQVNGADYRGHQNRTGprgAGRPCLFWD--QTQQHSYSSAsDPHGRWGLGaHNFCRNPDGDVQPWCYVaeTEEGIYWRY 113
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE---SGRPCQAWDsqTPHRHSKYTP-ENFPAKGLG-ENYCRNPDGDERPWCYT--TDPRVRWEY 73


                  ....*.
gi 359279863  114 CDIPSC 119
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
180-284 7.79e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.41  E-value: 7.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863  180 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRDA--ASGSLLRAFDGARP 252
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIrAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGpsASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 359279863  253 PPsgPLRLGTAALLLTFRSDARGHAQGFALTY 284
Cdd:pfam00431  81 PE--DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 189-284 1.35e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 74.73  E-value: 1.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863   189 GVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRD--AASGSLLRAFDGARPPPSgPLRLG 261
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIrAPPGYRIELQFTDFDLESSDnceyDYVEIYDgpSASSPLLGRFCGSEAPPP-VISSS 79

                           90       100
                   ....*....|....*....|...
gi 359279863   262 TAALLLTFRSDARGHAQGFALTY 284
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 124-165 6.51e-07

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 46.68  E-value: 6.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 359279863  124 YLGCFVDSGAPPALSGP-SGTSTKLTVQVCLRFCRMKGYQLCG 165
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGsSGDYDDMTPEKCIAFCSAAGYTYAG 43
 
Name Accession Description Interval E-value
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 34-119 4.40e-21

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 86.29  E-value: 4.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863    34 SECFQVNGADYRGHQNRTGPrgaGRPCLFWDQTQQHSYSSASDPHGRWGLGaHNFCRNPDGDV-QPWCYVaeTEEGIYWR 112
Cdd:smart00130   1 RECYAGNGESYRGTVSVTKS---GKPCQRWDSQTPHLHRFTPESFPDLGLE-ENYCRNPDGDSeGPWCYT--TDPNVRWE 74


                   ....*..
gi 359279863   113 YCDIPSC 119
Cdd:smart00130  75 YCDIPQC 81
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 35-119 4.62e-21

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 86.28  E-value: 4.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863  35 ECFQVNGADYRGHQNRTGPrgaGRPCLFWD--QTQQHSYSSASDPHGrwgLGAHNFCRNPDGDV-QPWCYVaeTEEGIYW 111
Cdd:cd00108    3 DCYWGNGESYRGTVSTTKS---GKPCQRWNsqLPHQHKFNPERFPEG---LLEENYCRNPDGDPeGPWCYT--TDPNVRW 74


                 ....*...
gi 359279863 112 RYCDIPSC 119
Cdd:cd00108   75 EYCDIPRC 82
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 180-285 2.34e-20

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 2.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863 180 CQGNWTAP-QGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRD--AASGSLLRAFDGAR 251
Cdd:cd00041    1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIeAPPGYRIRLTFEDFDLESSPncsyDYLEIYDgpSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 359279863 252 PPPsgPLRLGTAALLLTFRSDARGHAQGFALTYR 285
Cdd:cd00041   81 LPP--PIISSGNSLTVRFRSDSSVTGRGFKATYS 112
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 36-119 1.91e-17

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 76.19  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863   36 CFQVNGADYRGHQNRTGprgAGRPCLFWD--QTQQHSYSSAsDPHGRWGLGaHNFCRNPDGDVQPWCYVaeTEEGIYWRY 113
Cdd:pfam00051   1 CYHGNGESYRGTVSTTE---SGRPCQAWDsqTPHRHSKYTP-ENFPAKGLG-ENYCRNPDGDERPWCYT--TDPRVRWEY 73


                  ....*.
gi 359279863  114 CDIPSC 119
Cdd:pfam00051  74 CDIPRC 79
CUB pfam00431
CUB domain;
180-284 7.79e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.41  E-value: 7.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863  180 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRDA--ASGSLLRAFDGARP 252
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIrAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGpsASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 359279863  253 PPsgPLRLGTAALLLTFRSDARGHAQGFALTY 284
Cdd:pfam00431  81 PE--DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 189-284 1.35e-16

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 74.73  E-value: 1.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359279863   189 GVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR----DRLELRD--AASGSLLRAFDGARPPPSgPLRLG 261
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIrAPPGYRIELQFTDFDLESSDnceyDYVEIYDgpSASSPLLGRFCGSEAPPP-VISSS 79

                           90       100
                   ....*....|....*....|...
gi 359279863   262 TAALLLTFRSDARGHAQGFALTY 284
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 124-165 6.51e-07

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 46.68  E-value: 6.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 359279863  124 YLGCFVDSGAPPALSGP-SGTSTKLTVQVCLRFCRMKGYQLCG 165
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGsSGDYDDMTPEKCIAFCSAAGYTYAG 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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