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Conserved domains on  [gi|373838757|ref|NP_001243315|]
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leucine-rich repeat-containing protein 39 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-281 7.93e-40

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 145.08  E-value: 7.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  22 IKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTgllkipEF 101
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 102 IGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRdICDLPQELSNLLKLTHL 181
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 182 DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQtISNMKNLGTLVLSNNKLQDIP 261
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP 266

                        250       260
                 ....*....|....*....|
gi 373838757 262 VCMeEMANLRFVNFRDNPLK 281
Cdd:COG4886  267 PLA-NLTNLKTLDLSNNQLT 285
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-281 7.93e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 145.08  E-value: 7.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  22 IKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTgllkipEF 101
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 102 IGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRdICDLPQELSNLLKLTHL 181
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 182 DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQtISNMKNLGTLVLSNNKLQDIP 261
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP 266

                        250       260
                 ....*....|....*....|
gi 373838757 262 VCMeEMANLRFVNFRDNPLK 281
Cdd:COG4886  267 PLA-NLTNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-290 3.10e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 3.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  77 SSLLKLNQLQEWQLHRTGllKIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLTRLQELILSYNKIKT-VPKELSNCASL 154
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSL 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNK-LEQLPDTIeRMQNLHTLWLQRN 232
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRN 485

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 233 EIT-CLPQTISNMKNLGTLVLSNNKLQ-DIPVCMEEMANLRFVNFRDNPLKLKVSLPPSE 290
Cdd:PLN00113 486 QFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-280 1.76e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  90 LHRTGLLKIPEFIgRFQNLIVLDLSRNTISEIPpGIGLLTRLQELILSYNKIKTVPkELSNCASLEKLELAVNRdICDLp 169
Cdd:cd21340    9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 170 qE-LSNLLKLTHLDLSMNDfttiplavlnmpalewLDMGsNKLEQLPDTIERMQN-LHTLWLQRNEITCLpQTISNMKNL 247
Cdd:cd21340   84 -EgLENLTNLEELHIENQR----------------LPPG-EKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNL 144

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 373838757 248 GTLVLSNNKLQDI-PVC--MEEMANLRFVNFRDNPL 280
Cdd:cd21340  145 EQLDASNNQISDLeELLdlLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
106-163 8.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  106 QNLIVLDLSRNTISEIPPGIGL-LTRLQELILSYNKIKTV-PKELSNCASLEKLELAVNR 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-281 7.93e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 145.08  E-value: 7.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  22 IKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTgllkipEF 101
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 102 IGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRdICDLPQELSNLLKLTHL 181
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 182 DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQtISNMKNLGTLVLSNNKLQDIP 261
Cdd:COG4886  188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP 266

                        250       260
                 ....*....|....*....|
gi 373838757 262 VCMeEMANLRFVNFRDNPLK 281
Cdd:COG4886  267 PLA-NLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-334 1.21e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCA 152
Cdd:COG4886  126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 153 SLEKLELAVNRdICDLPQELSNLLKLTHLDLSMNDFTTIPlAVLNMPALEWLDMGSNKLEQLPDTIErMQNLHTLWLQRN 232
Cdd:COG4886  206 NLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 233 EITCLpqtisNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQE 312
Cdd:COG4886  283 QLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                        250       260
                 ....*....|....*....|..
gi 373838757 313 SRRRADHQVNGSTTLPISINTD 334
Cdd:COG4886  358 LLSLLLTLLLTLGLLGLLEATL 379
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-290 3.10e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 3.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  77 SSLLKLNQLQEWQLHRTGllKIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLTRLQELILSYNKIKT-VPKELSNCASL 154
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSL 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNK-LEQLPDTIeRMQNLHTLWLQRN 232
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRN 485

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 233 EIT-CLPQTISNMKNLGTLVLSNNKLQ-DIPVCMEEMANLRFVNFRDNPLKLKVSLPPSE 290
Cdd:PLN00113 486 QFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-280 1.31e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.91  E-value: 1.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  97 KIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLTRLQELILSYNK-IKTVPKELSNCASLEKLELAVNRDICDLPQELSN 174
Cdd:PLN00113 155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 175 LLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNKLE-QLPDTIERMQNLHTLWLQRNEITC-LPQTISNMKNLGTLV 251
Cdd:PLN00113 235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILH 314

                        170       180       190
                 ....*....|....*....|....*....|
gi 373838757 252 L-SNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Cdd:PLN00113 315 LfSNNFTGKIPVALTSLPRLQVLQLWSNKF 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
19-291 1.43e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  19 EKRIKKLNEDLKREKefqhklVRIWEERVSLTKLREKVTREDGRVILkiEKEEWKTLPSSLLklNQLQEWQLHRTGLLKI 98
Cdd:PRK15370 166 EEAVQRMRDCLKNNK------TELRLKILGLTTIPACIPEQITTLIL--DNNELKSLPENLQ--GNIKTLYANSNQLTSI 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  99 PEFIGrfQNLIVLDLSRNTISEIPPGigLLTRLQELILSYNKIKTVPKELSNcaSLEKLELAVNrDICDLPQELSNllKL 178
Cdd:PRK15370 236 PATLP--DTIQEMELSINRITELPER--LPSALQSLDLFHNKISCLPENLPE--ELRYLSVYDN-SIRTLPAHLPS--GI 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 179 THLDLSMNDFTTIPLAVlnMPALEWLDMGSNKLEQLPDTIErmQNLHTLWLQRNEITCLPQTISnmKNLGTLVLSNNKLQ 258
Cdd:PRK15370 307 THLNVQSNSLTALPETL--PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALT 380

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 373838757 259 DIPvcmEEM-ANLRFVNF-RDNPLKLKVSLPP--SEG 291
Cdd:PRK15370 381 NLP---ENLpAALQIMQAsRNNLVRLPESLPHfrGEG 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-304 2.84e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPkELSNCA 152
Cdd:COG4886  172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 153 SLEKLELAVNRdICDLPqELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN 232
Cdd:COG4886  251 NLEELDLSNNQ-LTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373838757 233 EITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQ 304
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-289 8.64e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 8.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 105 FQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH---- 180
Cdd:COG4886   25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTEldls 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 181 -------------LDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNL 247
Cdd:COG4886  105 gneelsnltnlesLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 373838757 248 GTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKlkvSLPPS 289
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT---DLPEP 223
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-293 9.11e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.27  E-value: 9.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  75 LPSSLLKLNQLQEWQLHRTGLL-KIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLTRLQELILSYNKIK-TVPKELSNC 151
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSL 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 152 ASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNKLE-QLPDTIERMQNLHTLWL 229
Cdd:PLN00113 332 PRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRL 411

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 373838757 230 QRNEITC-LPQTISNMKNLGTLVLSNNKLQ-DIPVCMEEMANLRFVNFRDNplKLKVSLPPSEGTD 293
Cdd:PLN00113 412 QDNSFSGeLPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARN--KFFGGLPDSFGSK 475
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-289 9.87e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 9.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  97 KIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLT-RLQELILSYNKIkTVPKELSNCASLEKLELAVNRDICDLPQELSN 174
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNF-TGSIPRGSIPNLETLDLSNNMLSGEIPNDIGS 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 175 LLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNKLE-QLPDTIERMQNLHTLWLQRNEITC-LPQTISNMKNLGTLV 251
Cdd:PLN00113 163 FSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLD 242

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 373838757 252 LSNNKLQ-DIPVCMEEMANLRFVNFRDNplKLKVSLPPS 289
Cdd:PLN00113 243 LVYNNLTgPIPSSLGNLKNLQYLFLYQN--KLSGPIPPS 279
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-217 4.22e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 4.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  66 KIEKEEWKtlpssllkLNQLQEWQLHRTGLL-KIPEFIGRfQNLIVLDLSRNTISE-IPPGIGLLTRLQELILSYNKIK- 142
Cdd:PLN00113 443 RINSRKWD--------MPSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSg 513

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373838757 143 TVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFT-TIPLAVLNMPALEWLDMGSNKLE-QLPDT 217
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPST 590
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-280 1.76e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  90 LHRTGLLKIPEFIgRFQNLIVLDLSRNTISEIPpGIGLLTRLQELILSYNKIKTVPkELSNCASLEKLELAVNRdICDLp 169
Cdd:cd21340    9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 170 qE-LSNLLKLTHLDLSMNDfttiplavlnmpalewLDMGsNKLEQLPDTIERMQN-LHTLWLQRNEITCLpQTISNMKNL 247
Cdd:cd21340   84 -EgLENLTNLEELHIENQR----------------LPPG-EKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNL 144

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 373838757 248 GTLVLSNNKLQDI-PVC--MEEMANLRFVNFRDNPL 280
Cdd:cd21340  145 EQLDASNNQISDLeELLdlLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-281 2.70e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 106 QNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSM 185
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 186 NDFTTIPLAVLNMPALEWLDMGSNkleqlpDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCME 265
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG 156

                        170
                 ....*....|....*.
gi 373838757 266 EMANLRFVNFRDNPLK 281
Cdd:COG4886  157 NLTNLKSLDLSNNQLT 172
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 27-277 1.96e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 56.04  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757   27 EDLKREKEFQHKLVRIWEERVSLTKLRE------KVTREDGRVILKIEKEEWK--------TLPSSLLKLNQLQEWQLHR 92
Cdd:PLN03210  611 ENLVKLQMQGSKLEKLWDGVHSLTGLRNidlrgsKNLKEIPDLSMATNLETLKlsdcsslvELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757   93 ---------------------TGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLlTRLQELILSYNKIKTVPKELSNC 151
Cdd:PLN03210  691 cenleilptginlkslyrlnlSGCSRLKSFPDISTNISWLDLDETAIEEFPSNLRL-ENLDELILCEMKSEKLWERVQPL 769

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  152 A--------SLEKLELAVNRDICDLPQELSNLLKLTHLDLsMN--DFTTIPLAVlNMPALEWLDM-GSNKLEQLPDTier 220
Cdd:PLN03210  770 TplmtmlspSLTRLFLSDIPSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsGCSRLRTFPDI--- 844

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 373838757  221 MQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN-NKLQDIPVCMEEMANLRFVNFRD 277
Cdd:PLN03210  845 STNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLETVDFSD 902
PLN03150 PLN03150
hypothetical protein; Provisional
 98-176 1.56e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  98 IPEFIGRFQNLIVLDLSRNTI-SEIPPGIGLLTRLQELILSYNKIK-TVPKELSNCASLEKLELAVNRDICDLPQELSNL 175
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513


                 .
gi 373838757 176 L 176
Cdd:PLN03150 514 L 514
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-270 6.06e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  75 LPSSLLKL----NQLQEWQLHRTGLLKIPEFIGRFQNLIVLdlsrntiseiPPGiglltrLQELILSYNKIKTVPKelsn 150
Cdd:PRK15387 260 LPPGLLELsifsNPLTHLPALPSGLCKLWIFGNQLTSLPVL----------PPG------LQELSVSDNQLASLPA---- 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 151 casleklelavnrdicdLPQELSNLLKLThldlsmNDFTTIPlavlNMPA-LEWLDMGSNKLEQLPDTierMQNLHTLWL 229
Cdd:PRK15387 320 -----------------LPSELCKLWAYN------NQLTSLP----TLPSgLQELSVSDNQLASLPTL---PSELYKLWA 369

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 373838757 230 QRNEITCLPQTISNMKNlgtLVLSNNKLQDIPVCMEEMANL 270
Cdd:PRK15387 370 YNNRLTSLPALPSGLKE---LIVSGNRLTSLPVLPSELKEL 407
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-289 1.34e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  42 IWEERVSLTKLREKVTREDGRVILKiekeewktlpsSLLKLNQlQEWQLHRTGLLKIPEFIGrfQNLIVLDLSRNTISEI 121
Cdd:PRK15370 149 IWSEWVKEAPAKEAANREEAVQRMR-----------DCLKNNK-TELRLKILGLTTIPACIP--EQITTLILDNNELKSL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 122 PPGigLLTRLQELILSYNKIKTVPKELSNcaSLEKLELAVNRdICDLPqelsnllklthldlsmndfttiplavlnmpal 201
Cdd:PRK15370 215 PEN--LQGNIKTLYANSNQLTSIPATLPD--TIQEMELSINR-ITELP-------------------------------- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 202 ewldmgsnklEQLPDTiermqnLHTLWLQRNEITCLPQTISNmkNLGTLVLSNNKLQDIPVCMEemANLRFVNFRDNPLK 281
Cdd:PRK15370 258 ----------ERLPSA------LQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLT 317


                 ....*....
gi 373838757 282 -LKVSLPPS 289
Cdd:PRK15370 318 aLPETLPPG 326
LRR_8 pfam13855
Leucine rich repeat;
106-163 8.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  106 QNLIVLDLSRNTISEIPPGIGL-LTRLQELILSYNKIKTV-PKELSNCASLEKLELAVNR 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
84-141 9.46e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757   84 QLQEWQLHRTGLLKI-PEFIGRFQNLIVLDLSRNTISEIPPG-IGLLTRLQELILSYNKI 141
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-263 1.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  79 LLKLNQLQEWQlhrTGLLKIPEFIGRFQNLIVLDLSRNTIS-EIPPGIGLLTR---LQELILSYNKI-----KTVPKELS 149
Cdd:cd00116   57 CLSLNETGRIP---RGLQSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLgdrglRLLAKGLK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 150 NCA-SLEKLELAVNR----DICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLnmpalewldmgsnkLEQLPDTiermQNL 224
Cdd:cd00116  134 DLPpALEKLVLGRNRlegaSCEALAKALRANRDLKELNLANNGIGDAGIRAL--------------AEGLKAN----CNL 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 373838757 225 HTLWLQRNEITC-----LPQTISNMKNLGTLVLSNNKLQDIPVC 263
Cdd:cd00116  196 EVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAA 239
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 77-205 1.42e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  77 SSLLKLNQLQewqLHRTGLLKIpEFIGRFQNLIVLDLSRNTISEI-------------------PPG----------IGL 127
Cdd:cd21340   43 EFLTNLTHLY---LQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlPPGekltfdprslAAL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 128 LTRLQELILSYNKIKTVpKELSNCASLEKLELAVNR--DICDLPQELSNLLKLTHLDLSMNDFTTIPL----AVLNMPAL 201
Cdd:cd21340  119 SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisDLEELLDLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSL 197


                 ....
gi 373838757 202 EWLD 205
Cdd:cd21340  198 EVLD 201
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-259 1.82e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  75 LPSSLLKL----NQL----------QEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGiglltrLQELILSYNK 140
Cdd:PRK15387 280 LPSGLCKLwifgNQLtslpvlppglQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQ 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 141 IKTVPKELSNCASLekleLAVNRDICDLPQELSNLLKLThldLSMNDFTTIPLavlnMPA-LEWLDMGSNKLEQLPdtiE 219
Cdd:PRK15387 354 LASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLTSLPV----LPSeLKELMVSGNRLTSLP---M 419

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 373838757 220 RMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQD 259
Cdd:PRK15387 420 LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN03150 PLN03150
hypothetical protein; Provisional
 213-284 2.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 2.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373838757 213 QLPDTIERMQNLHTLWLQRNEIT-CLPQTISNMKNLGTLVLSNNKLQ-DIPVCMEEMANLRFVNFRDNPLKLKV 284
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
222-280 2.79e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 373838757  222 QNLHTLWLQRNEITCLPQ-TISNMKNLGTLVLSNNKLQDI-PVCMEEMANLRFVNFRDNPL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 104-258 7.01e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  104 RFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNK-IKTVPkELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
Cdd:PLN03210  609 RPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKnLKEIP-DLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLD 687

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 373838757  183 LSMND-FTTIPLAVlNMPALEWLD-MGSNKLEQLPDTierMQNLHTLWLQRNEITCLPQTIsNMKNLGTLVLSNNKLQ 258
Cdd:PLN03210  688 MSRCEnLEILPTGI-NLKSLYRLNlSGCSRLKSFPDI---STNISWLDLDETAIEEFPSNL-RLENLDELILCEMKSE 760
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-257 2.11e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 175 LLKLTHLDLSMNDFTTIPLavLNM-PALEWLDMGSNKLEQLPDtIERMQNLHTLWLQRNEITCLpQTISNMKNLGTLVLS 253
Cdd:cd21340    1 LKRITHLYLNDKNITKIDN--LSLcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLG 76


                 ....
gi 373838757 254 NNKL 257
Cdd:cd21340   77 GNRI 80
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-235 2.51e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  67 IEKEEWKTLPSSLLKLNQLQEWQLHRT--GLLKIPEFIGRFQ---NLIVLDLSRNTISEipPGIGLL-------TRLQEL 134
Cdd:COG5238  192 IGDEGIEELAEALTQNTTVTTLWLKRNpiGDEGAEILAEALKgnkSLTTLDLSNNQIGD--EGVIALaealknnTTVETL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757 135 ILSYNKI-----KTVPKELSNCASLEKLELAVNRdICD-----LPQELSNLLKLTHLDLSMNDFTT---IPL--AVLNMP 199
Cdd:COG5238  270 YLSGNQIgaegaIALAKALQGNTTLTSLDLSVNR-IGDegaiaLAEGLQGNKTLHTLNLAYNGIGAqgaIALakALQENT 348

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 373838757 200 ALEWLDMGSNKL-----EQLPDTIERMQNLHTLWLQRNEIT 235
Cdd:COG5238  349 TLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIG 389
LRR_8 pfam13855
Leucine rich repeat;
129-211 2.53e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373838757  129 TRLQELILSYNKIKTVPKELsncasleklelavnrdicdlpqeLSNLLKLTHLDLSMNDFTTIPLAVL-NMPALEWLDMG 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGA-----------------------FKGLSNLKVLDLSNNLLTTLSPGAFsGLPSLRYLDLS 57


                  ....
gi 373838757  208 SNKL 211
Cdd:pfam13855  58 GNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 121-195 5.47e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 5.47e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373838757 121 IPPGIGLLTRLQELILSYNKIK-TVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFT-TIPLAV 195
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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