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Conserved domains on  [gi|374253785|ref|NP_001243372|]
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proline-rich transmembrane protein 2 isoform 3 [Homo sapiens]

Protein Classification

CD225/dispanin family protein( domain architecture ID 13453843)

CD225/dispanin family protein similar to Homo sapiens tumor suppressor candidate 5 (TUSC5), which may be involved in fat metabolism, and synapse differentiation-inducing gene protein 1 (SynDIG1), which may regulate AMPA receptor content at nascent synapses and have a role in postsynaptic development and maturation. CD225 is an interferon-inducible transmembrane protein associated with interferon induced cell growth suppression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-296 1.95e-10

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


:

Pssm-ID: 461336  Cd Length: 68  Bit Score: 55.97  E-value: 1.95e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 374253785  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMVSP 296
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRD 33
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 29-218 4.10e-04

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  29 EAETGPPQVLAGVPDQPEAPQPGPNTTAAPvdsgPKAGLAPETTETPAGASETAQatdlslsPGGESKANCSPEDPCQET 108
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPASSGPPEEAAR----PAAPAAPAAPAAPAPAGAAAA-------PAEASAAPAPGVAAPEHH 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785 109 VSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQ 188
Cdd:PRK07764 654 PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733

                        170       180       190
                 ....*....|....*....|....*....|
gi 374253785 189 AGDGEEGPAPEPHSPPSKKSPPANGAPPRV 218
Cdd:PRK07764 734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-296 1.95e-10

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 55.97  E-value: 1.95e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 374253785  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMVSP 296
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRD 33
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 29-218 4.10e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  29 EAETGPPQVLAGVPDQPEAPQPGPNTTAAPvdsgPKAGLAPETTETPAGASETAQatdlslsPGGESKANCSPEDPCQET 108
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPASSGPPEEAAR----PAAPAAPAAPAAPAPAGAAAA-------PAEASAAPAPGVAAPEHH 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785 109 VSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQ 188
Cdd:PRK07764 654 PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733

                        170       180       190
                 ....*....|....*....|....*....|
gi 374253785 189 AGDGEEGPAPEPHSPPSKKSPPANGAPPRV 218
Cdd:PRK07764 734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 264-296 1.95e-10

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 55.97  E-value: 1.95e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 374253785  264 KPRDYIILAILSCFCPMWPVNIVAFAYAVMVSP 296
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRD 33
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 29-218 4.10e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  29 EAETGPPQVLAGVPDQPEAPQPGPNTTAAPvdsgPKAGLAPETTETPAGASETAQatdlslsPGGESKANCSPEDPCQET 108
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPASSGPPEEAAR----PAAPAAPAAPAAPAPAGAAAA-------PAEASAAPAPGVAAPEHH 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785 109 VSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQ 188
Cdd:PRK07764 654 PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733

                        170       180       190
                 ....*....|....*....|....*....|
gi 374253785 189 AGDGEEGPAPEPHSPPSKKSPPANGAPPRV 218
Cdd:PRK07764 734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763
PHA03247 PHA03247
large tegument protein UL36; Provisional
 25-216 4.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785   25 PGHSEAETGPPQVLAGVPDQPEAPQPGPNTtAAPVDSGPKAGLAPETTETPA------GASETAQATDLSLSPGGESKAN 98
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTSAQPTapppppGPPPPSLPLGGSVAPGGDVRRR 2865

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785   99 CSPEDPCQE--TVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPT------PKPALQPELPTQEDPTPEI 170
Cdd:PHA03247 2866 PPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQpqppppPQPQPPPPPPPRPQPPLAP 2945

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 374253785  171 LSESVGEKQENGAVVPLQAGDGEEG--PAPEPHSPPSKKSPPANGAPP 216
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASST 2993
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 20-216 1.07e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  20 VPGEGPGHSEAETGPPQVLAGVPDQPE-APQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKAN 98
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARpAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  99 CSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEK 178
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDD 747

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 374253785 179 QENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPP 216
Cdd:PRK07764 748 PPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 1-80 6.86e-03

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 38.02  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785   1 MAASSSEISEMKGVEEsPKVPGEGPGHSEAETGPPQvLAGVPDQPEAPQPgPNTTAAPVDSGPKAGLAPettETPAGASE 80
Cdd:PRK13700 589 LAAREAEGRQMASLFE-PDVPEVASGEDVTQAEQPQ-QPQQPQQPQQPQQ-PQQPVSPVINDKKSDAGV---NVPAGGIE 662
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
25-239 7.41e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 7.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785  25 PGHSEAETGPPQVLAG-VPDQPEAPQPGPNTTAAPVDSGPKAGLAPEttetPAGASETAQATDLSLSPGGESKANCSPED 103
Cdd:PRK12323 365 PGQSGGGAGPATAAAApVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA----AAAAARAVAAAPARRSPAPEALAAARQAS 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374253785 104 PCQETVSKPEVSKEATADQGSrlESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGA 183
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAA--ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 374253785 184 VVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSP 239
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLP 574
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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