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Conserved domains on  [gi|375364515|ref|NP_001243624|]
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PR domain-containing protein 11 isoform 1 [Homo sapiens]

Protein Classification

PR domain-containing protein 11( domain architecture ID 17511780)

PR domain-containing protein 11 (PRDM11) may be involved in transcription regulation

EC:  2.1.1.-
Gene Symbol:  PRDM11
Gene Ontology:  GO:0005515|GO:1904047
PubMed:  12372294|17013555

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 5.81e-87

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


:

Pssm-ID: 380972  Cd Length: 127  Bit Score: 276.74  E-value: 5.81e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375364515  189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195    81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
zf_PR_Knuckle super family cl39781
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 1.08e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


The actual alignment was detected with superfamily member pfam18445:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.66  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*..
gi 375364515    75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445   12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 5.81e-87

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 276.74  E-value: 5.81e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375364515  189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195    81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 129-230 1.21e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.57  E-value: 1.21e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515    129 VRCvNEVIPKGHIFGPYEGQISTQD---KSAGFFSWLIVDKNNRYKS-----IDGSDetKANWMRYVVISREEREQNLLA 200
Cdd:smart00317   15 VRA-TEDIPKGEFIGEYVGEIITSEeaeERPKAYDTDGAKAFYLFDIdsdlcIDARR--KGNLARFINHSCEPNCELLFV 91

                            90       100       110
                    ....*....|....*....|....*....|.
gi 375364515    201 FQ-HSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:smart00317   92 EVnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 130-225 4.31e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.05  E-value: 4.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515   130 RCV--NEVIPKGHIFGPYEGQ--ISTQDKSAGFFSWLIVDKNNRYK------------SIDGSDETKANWMRYVvisREE 193
Cdd:pfam00856    2 RGLfaTEDIPKGEFIGEYVEVllITKEEADKRELLYYDKLELRLWGpylftldedseyCIDARALYYGNWARFI---NHS 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 375364515   194 REQNLLAF----QHSERIYFRACRDIRPGEWLRVWY 225
Cdd:pfam00856   79 CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 1.08e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.66  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*..
gi 375364515    75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445   12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 5.81e-87

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 276.74  E-value: 5.81e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375364515  189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195    81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 111-233 9.23e-40

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 143.53  E-value: 9.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  111 LTIPQGMEVvkdtsGESDVR------CVNEVIPKGHIFGPYEGQISTQDKSAGF-FSWLIVDKNNRYKSIDGSDETKANW 183
Cdd:cd19193     2 LTLPPGLSI-----KRSSIPgaglgvWAEAPIPKGMVFGPYEGEIVEDEEAADSgYSWQIYKGGKLSHYIDAKDESKSNW 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 375364515  184 MRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19193    77 MRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 113-226 3.21e-27

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 106.13  E-value: 3.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  113 IPQGMEVVKDTSGESDVR-CVNEVIPKGHIFGPYEGQIstqdksagffswlivdknnryksidgsdetkaNWMRYVVISR 191
Cdd:cd10534     1 LPAGLELVLSSIPEGGLGvFARRTIPAGTRFGPLEGVV--------------------------------NWMRFVRPAR 48

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 375364515  192 EEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYS 226
Cdd:cd10534    49 NEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-233 2.28e-26

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 105.10  E-value: 2.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  112 TIPQGMeVVKDTSGESDVRCV--NEVIPKGHIFGPYEGQISTQDK-----SAGFFsWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19187     2 SLPRNL-TLKYSSVGREVLGVwsSDYIPRGTRFGPLVGEIYTNDPvpkgaNRKYF-WRIYSNGEFYHYIDGFDPSKSNWM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 375364515  185 RYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19187    80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 131-229 2.54e-25

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 102.17  E-value: 2.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  131 CVNEVIPKGHIFGPYEGQISTQDKSAGFFS-----WLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHS 204
Cdd:cd19191    20 CAAQRIPQGTWIGPFEGVLVSPEKQIGAVRntqhlWEIYDQEGTLQHfIDGGDPSKSSWMRYIRCARHCGEQNLTVVQYR 99

                          90       100
                  ....*....|....*....|....*
gi 375364515  205 ERIYFRACRDIRPGEWLRVWYSEDY 229
Cdd:cd19191   100 GCIFYRACRDIPRGTELLVWYDDSY 124
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 108-233 2.80e-25

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 102.11  E-value: 2.80e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  108 RAALTIPQGMEVVKDTSGESDVRCVNEvIPKGHIFGPYEGQI-STQDKSAgFFSWLIVDKNNRYKSIDGSDETKANWMRY 186
Cdd:cd19199     2 RARSSLPDNLEIRQLEDGSEGVFALVP-LVKRTQFGPFEAKRvARLDGFA-VFPLKVFEKDGSVVYLDTSNEDDCNWMMF 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 375364515  187 VVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19199    80 VRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 111-233 6.29e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.54  E-value: 6.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  111 LTIPQGMEVVKDTSGE---SDVRCvNEVIPKGHIFGPYEG------QISTQDKSAgfFSWLIVDKNNRYKSIDGSDETkA 181
Cdd:cd19198     1 LDLPEGLRVLQTSFGGtphYGVFC-KKTIPKGTRFGPFRGrvvntsEIKTYDDNS--FMWEIFEDGKLSHFIDGRGST-G 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 375364515  182 NWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19198    77 NWMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFM 128
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 136-225 1.25e-22

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 94.43  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  136 IPKGHIFGPYEGQIST-QDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRD 214
Cdd:cd19188    28 IPKGRKFGPFVGEKKKrSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKP 107

                          90
                  ....*....|.
gi 375364515  215 IRPGEWLRVWY 225
Cdd:cd19188   108 IAPGEELLCWY 118
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 108-233 4.36e-20

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 87.41  E-value: 4.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  108 RAALTIPQGMEVVKdtSGESDVRCVNE-VIPKGHIFGPYEGQISTQDKSAG--FFSWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19194     1 RARASLPLILQIFR--FGETLGGVFAKrRIPKRTQFGPLEGPLVKKSELKDnkIHPLELEEDDGEDLYFDLSDENKCNWM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 375364515  185 RYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19194    79 MFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 108-233 3.16e-19

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 84.82  E-value: 3.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  108 RAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQIS------TQDKSAGFFSWLIVDKNNRYKSIDGSDETKA 181
Cdd:cd19189     1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQShsaevaDWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 375364515  182 NWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19189    81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 136-230 1.18e-18

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 83.18  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  136 IPKGHIFGPYEGQISTQD----KSAGFFSWLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFR 210
Cdd:cd19196    25 IKEGTEMGPYTGRIVSPEdvdpCKNNNLMWEVFNEDGTVSHfIDASQENHRSWMTFVNCARNEQEQNLEVVQIGESIYYR 104

                          90       100
                  ....*....|....*....|
gi 375364515  211 ACRDIRPGEWLRVWYSEDYM 230
Cdd:cd19196   105 AIKDIPPDQELLVWYGNSYN 124
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 136-231 7.74e-17

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 78.18  E-value: 7.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  136 IPKGHIFGPYEGQISTQDKSAGFfSWLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRD 214
Cdd:cd19200    34 IEVGEKFGPFVGVQRSSVKDPTY-AWEIVDEFGKVKFwIDASEPGTGNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRD 112

                          90
                  ....*....|....*..
gi 375364515  215 IRPGEWLRVwysedYMK 231
Cdd:cd19200   113 IQPGEELLL-----YMK 124
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 123-228 5.08e-13

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 67.07  E-value: 5.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  123 TSGESDVRCVNEvIPKGHIFGPYEGQ-----------ISTQDKSAGFFSWLIVdknnryKSIDGSDETKANWMRYVVISR 191
Cdd:cd19192    16 TDIFTSVVTTTD-IPAGTIFGPCVLSftlgydiadiaLKTTDKRVVPYIFRVD------TGACNGSSEPSDWLRLVQPAR 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 375364515  192 EEREQNLLAFQHSE-RIYFRACRDIRPGEWLRVWYSED 228
Cdd:cd19192    89 DRHEQNLEAFRKNEgQVYFRTLRRIRKGEELLVWYSDE 126
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 88-229 4.29e-12

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 65.34  E-value: 4.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515   88 PNHGPPVfvsdtPVPVGIPDRaaLTIPQGMEVVKDTSGESDVRCVNEV-IPKGHIFGPYEGQISTQDKSAgFFSWLIVDK 166
Cdd:cd19214    12 PKEGSPY-----KAPIYIPDD--IPIPSEFELRESNIPGTGLGIWTKRkIEVGEKFGPYVGEQRSNLKDP-SYGWEVLDE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375364515  167 NNRYK-SIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWY-SEDY 229
Cdd:cd19214    84 FGNVKfCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMkSEDY 148
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 129-227 1.29e-11

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 62.82  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  129 VRCVNEVIPKGHIFGPYEGQISTQDKSAG-------FFSWlivdknnryksIDGSD-ETKANWMRYVVISREEREQNLLA 200
Cdd:cd10520    23 VWCVGDALQKGTFLGPLEEELESHDLTEGgsprqeeSGQS-----------GDVLAcEQSSKWMRFACRARSEEESNVAV 91

                          90       100
                  ....*....|....*....|....*..
gi 375364515  201 FQHSERIYFRACRDIRPGEWLRVWYSE 227
Cdd:cd10520    92 VRLSGRLHLRVCKDIEPGSELLLWPEE 118
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 136-226 3.45e-11

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 60.99  E-value: 3.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  136 IPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSI---DGSDETKANWMRYVVISREEREQNLLAFQHSE--RIYFR 210
Cdd:cd19197     1 IPAGLRLGPVPGIFKLGKYLSDRKEPGNKKKVRRVRGDylvDESGSPATEWIGLVRAARNNQEQNLEAIADLPggQIFYR 80

                          90
                  ....*....|....*.
gi 375364515  211 ACRDIRPGEWLRVWYS 226
Cdd:cd19197    81 ALRDIQPGEELTVWYS 96
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 88-231 6.80e-10

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 59.12  E-value: 6.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515   88 PNHGPPVfvsdtPVPVGIPDRaaLTIPQGMEVvKDTS--GESDVRCVNEVIPKGHIFGPYEG-QISTQDKSAgfFSWLIV 164
Cdd:cd19213     2 PKEGSPY-----EAPVYIPDD--IPIPSDFEL-RESSipGAGLGVWAKRKIEAGERFGPYTGvQRSTLKDTN--FGWEQI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  165 DKNNRYKS------------------IDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVwys 226
Cdd:cd19213    72 LNDVEVSSqegcitkivddlgnekfcVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLV--- 148


                  ....*
gi 375364515  227 edYMK 231
Cdd:cd19213   149 --YVK 151
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 113-228 8.15e-10

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 57.74  E-value: 8.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  113 IPQGMEVVKDTSGESDVRCV--NEVIPKGHIFGPYEGQISTQDKSAGffSWLIVDKNNRYKSIDGSDET--KANWMRYVV 188
Cdd:cd19201     3 LPGELELRKPSQDAGRSGGVwaKQPLPEGTRFGPYPGKLVKEPLDPS--YEWKVEAQGSKGGEGLLLLTedSGTWLKLVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 375364515  189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSED 228
Cdd:cd19201    81 SADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREP 120
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 129-230 1.21e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.57  E-value: 1.21e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515    129 VRCvNEVIPKGHIFGPYEGQISTQD---KSAGFFSWLIVDKNNRYKS-----IDGSDetKANWMRYVVISREEREQNLLA 200
Cdd:smart00317   15 VRA-TEDIPKGEFIGEYVGEIITSEeaeERPKAYDTDGAKAFYLFDIdsdlcIDARR--KGNLARFINHSCEPNCELLFV 91

                            90       100       110
                    ....*....|....*....|....*....|.
gi 375364515    201 FQ-HSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:smart00317   92 EVnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 134-231 1.41e-07

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 51.19  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  134 EVIPKGHIFGPYEGQISTQDKSA-----GFFSWLIVDKNNRYKSIDGSdeTKANWMRYVVISRE---EREQNLLAFQHse 205
Cdd:cd10522    21 ETIAKGEFVGEYTGEVLDRWEEDrdsvyHYDPLYPFDLNGDILVIDAG--KKGNLTRFINHSDQpnlELIVRTLKGEQ-- 96

                          90       100
                  ....*....|....*....|....*.
gi 375364515  206 RIYFRACRDIRPGEWLRVWYSEDYMK 231
Cdd:cd10522    97 HIGFVAIRDIKPGEELFISYGPKYWK 122
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 105-230 1.82e-05

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 45.36  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515  105 IPDRAALTIPQgmevVKDTSGESDVRCVNevipKGHIFGPYEGQ---ISTQDKSAGF-FSWLIV-DKNNRYKSIDGSDET 179
Cdd:cd19190     5 VPDRFSLKSSK----VQDGMGLYTARRVK----KGEKFGPFAGEkrmPNELDESMDPrLMWEVRgSKGEVLYILDASNPR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 375364515  180 KANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:cd19190    77 HSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 130-225 4.31e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.05  E-value: 4.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364515   130 RCV--NEVIPKGHIFGPYEGQ--ISTQDKSAGFFSWLIVDKNNRYK------------SIDGSDETKANWMRYVvisREE 193
Cdd:pfam00856    2 RGLfaTEDIPKGEFIGEYVEVllITKEEADKRELLYYDKLELRLWGpylftldedseyCIDARALYYGNWARFI---NHS 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 375364515   194 REQNLLAF----QHSERIYFRACRDIRPGEWLRVWY 225
Cdd:pfam00856   79 CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 1.08e-03

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.66  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*..
gi 375364515    75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445   12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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