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Conserved domains on  [gi|378744190|ref|NP_001243759|]
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acid-sensing ion channel 1 isoform c [Homo sapiens]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 235)

amiloride-sensitive sodium channel family protein such as vertebrate acid-sensing ion channels which are cation channels with high affinity for sodium; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ENaC super family cl47122
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
64-544 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00859:

Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 543.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190   64 LVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNeVATTELAFPAVTLCNTNA 143
Cdd:TIGR00859   6 LVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  144 VRLS----QLSYPDLLY------------------------LAPMLGLDESDD-PGVPLAPPGPEAFSG----------- 183
Cdd:TIGR00859  85 YRYSkvkhLLEELDLETaqtllslygynsslarsarsnnrnRIPLVVLDETLPrHPVPRDLFTRQVHNKlisnrsnspqv 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  184 --------------------------------EPFNLH----------RFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVV 221
Cdd:TIGR00859 165 nasdwkvgfklcnnngsdcfyrtytsgvqavrEWYRFHyinifaqvpaEDKDRMGYQLEDFILTCRFDGESCDARNFTHF 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  222 FT-RYGKCYTFNSGRDgRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVA 300
Cdd:TIGR00859 245 HHpMYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  301 PGFQTFVACQEQRLIYLPPPWGTCKAVTmdSDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPE 374
Cdd:TIGR00859 318 PGTETSISMQEDELQRLGGPYGDCTENG--SDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  375 QYKECADPALDFLVEKDQE----YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFF 446
Cdd:TIGR00859 396 QHPDWAYCYYKLYAEFDQEelgcFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  447 EVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SS 513
Cdd:TIGR00859 476 EELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVS 555
                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 378744190  514 ADKGVALSLDDVKR--------HNPCESLRGHPAGMTYA 544
Cdd:TIGR00859 556 ADTPPSLQLDDPPTfpsalplpHASGLSLPGTPPPNYNT 594
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
64-544 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 543.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190   64 LVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNeVATTELAFPAVTLCNTNA 143
Cdd:TIGR00859   6 LVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  144 VRLS----QLSYPDLLY------------------------LAPMLGLDESDD-PGVPLAPPGPEAFSG----------- 183
Cdd:TIGR00859  85 YRYSkvkhLLEELDLETaqtllslygynsslarsarsnnrnRIPLVVLDETLPrHPVPRDLFTRQVHNKlisnrsnspqv 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  184 --------------------------------EPFNLH----------RFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVV 221
Cdd:TIGR00859 165 nasdwkvgfklcnnngsdcfyrtytsgvqavrEWYRFHyinifaqvpaEDKDRMGYQLEDFILTCRFDGESCDARNFTHF 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  222 FT-RYGKCYTFNSGRDgRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVA 300
Cdd:TIGR00859 245 HHpMYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  301 PGFQTFVACQEQRLIYLPPPWGTCKAVTmdSDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPE 374
Cdd:TIGR00859 318 PGTETSISMQEDELQRLGGPYGDCTENG--SDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  375 QYKECADPALDFLVEKDQE----YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFF 446
Cdd:TIGR00859 396 QHPDWAYCYYKLYAEFDQEelgcFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  447 EVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SS 513
Cdd:TIGR00859 476 EELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVS 555
                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 378744190  514 ADKGVALSLDDVKR--------HNPCESLRGHPAGMTYA 544
Cdd:TIGR00859 556 ADTPPSLQLDDPPTfpsalplpHASGLSLPGTPPPNYNT 594
ASC pfam00858
Amiloride-sensitive sodium channel;
67-490 1.11e-125

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 375.74  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190   67 FANSCTLHGTNHIFVEGGPgPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTE-LAFPAVTLCNTNAVR 145
Cdd:pfam00858   1 FCENTSIHGVRYIKSKDGF-LRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEEILYVWnVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  146 LSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEAFSGEPFNLHRFYNRSC--------------HRLEDMLLYCSYQGG 211
Cdd:pfam00858  80 YSALKELSLFYDNLSFLLYLKFKFLEKILKSLTSNTEELEDELKLLLDFTNellnslsgyilnlgLRCEDLIVSCSFGGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  212 --PCGPhNFSVVFTRYGKCYTFNSGRDGRPR--LKTMKGGTGNGLEIMLDIQQDEYlpvwgETDETSFEAGIKVQIHSQD 287
Cdd:pfam00858 160 keDCSA-NFTPILTEYGNCYTFNSKDNGSKLypRRLKGAGSGRGLSLILNIQQSET-----YSPLDYQAAGFKVSIHSPG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  288 EPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCkaVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGD 367
Cdd:pfam00858 234 EPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGNC--TFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLP 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  368 APYCTPEQYKeCADPALDFLVE-KDQEYCV-CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK----SEQYIGENILV 441
Cdd:pfam00858 312 PGTKTGADIP-CLLNYEDHLLEvNEGLSCQdCLPPCNETEYETEISYSTWPSLSSQLFLLYYELStynnSSSTIRENLAK 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 378744190  442 LDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY 490
Cdd:pfam00858 391 LNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
64-544 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 543.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190   64 LVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNeVATTELAFPAVTLCNTNA 143
Cdd:TIGR00859   6 LVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLS-VNSDKLTFPAVTLCNLNP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  144 VRLS----QLSYPDLLY------------------------LAPMLGLDESDD-PGVPLAPPGPEAFSG----------- 183
Cdd:TIGR00859  85 YRYSkvkhLLEELDLETaqtllslygynsslarsarsnnrnRIPLVVLDETLPrHPVPRDLFTRQVHNKlisnrsnspqv 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  184 --------------------------------EPFNLH----------RFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVV 221
Cdd:TIGR00859 165 nasdwkvgfklcnnngsdcfyrtytsgvqavrEWYRFHyinifaqvpaEDKDRMGYQLEDFILTCRFDGESCDARNFTHF 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  222 FT-RYGKCYTFNSGRDgRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVA 300
Cdd:TIGR00859 245 HHpMYGNCYTFNSGEN-SNLLTSSMPGAENGLKLVLDIEQDEYLPLLST------EAGARVMVHSQDEPPFIDDLGFGVR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  301 PGFQTFVACQEQRLIYLPPPWGTCKAVTmdSDLDFFD----SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPE 374
Cdd:TIGR00859 318 PGTETSISMQEDELQRLGGPYGDCTENG--SDVPVENlynsSYSIQACLRSCFQRYMVENCGCAYYHYPlpGGAEYCNYE 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  375 QYKECADPALDFLVEKDQE----YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE----QYIGENILVLDIFF 446
Cdd:TIGR00859 396 QHPDWAYCYYKLYAEFDQEelgcFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNeyniTLIRNGIAKLNIFF 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  447 EVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-QKEAKR------------SS 513
Cdd:TIGR00859 476 EELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRfRKWWQRrrgppyaeppepVS 555
                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 378744190  514 ADKGVALSLDDVKR--------HNPCESLRGHPAGMTYA 544
Cdd:TIGR00859 556 ADTPPSLQLDDPPTfpsalplpHASGLSLPGTPPPNYNT 594
ASC pfam00858
Amiloride-sensitive sodium channel;
67-490 1.11e-125

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 375.74  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190   67 FANSCTLHGTNHIFVEGGPgPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTE-LAFPAVTLCNTNAVR 145
Cdd:pfam00858   1 FCENTSIHGVRYIKSKDGF-LRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEEILYVWnVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  146 LSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEAFSGEPFNLHRFYNRSC--------------HRLEDMLLYCSYQGG 211
Cdd:pfam00858  80 YSALKELSLFYDNLSFLLYLKFKFLEKILKSLTSNTEELEDELKLLLDFTNellnslsgyilnlgLRCEDLIVSCSFGGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  212 --PCGPhNFSVVFTRYGKCYTFNSGRDGRPR--LKTMKGGTGNGLEIMLDIQQDEYlpvwgETDETSFEAGIKVQIHSQD 287
Cdd:pfam00858 160 keDCSA-NFTPILTEYGNCYTFNSKDNGSKLypRRLKGAGSGRGLSLILNIQQSET-----YSPLDYQAAGFKVSIHSPG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  288 EPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCkaVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGD 367
Cdd:pfam00858 234 EPPDVDKRGFSVPPGTETSVGIQPTEITTLKRPYGNC--TFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLP 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  368 APYCTPEQYKeCADPALDFLVE-KDQEYCV-CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK----SEQYIGENILV 441
Cdd:pfam00858 312 PGTKTGADIP-CLLNYEDHLLEvNEGLSCQdCLPPCNETEYETEISYSTWPSLSSQLFLLYYELStynnSSSTIRENLAK 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 378744190  442 LDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY 490
Cdd:pfam00858 391 LNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
199-486 2.38e-38

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 148.84  E-value: 2.38e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  199 LEDMLLYCSYQGGPCgphNFSVVFTR-----YGKCYTFNSGRDGRprLKTMKGGTGNGLEIMLDIQQDEYLPvwgetdeT 273
Cdd:TIGR00867 305 KHELILKCSFNGKPC---DIDRDFTLhidpvFGNCYTFNYNRSVN--LSSSRAGPMYGLRLLLFVNQSDYLP-------T 372
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  274 SFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCkaVTMDSDLDFFDS---YSITACRIDCET 350
Cdd:TIGR00867 373 TEAAGVRLTIHDKDEFPFPDTFGYSAPTGYISSFGVRLKQMSRLPAPYGNC--VDTGKDSSYIYKgyiYSPEGCHRSCFQ 450
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378744190  351 RYLVENCNCrmvhmpGDAPYCTPEQYKECADP---ALDFL---------VEKDQEYCVCEMPCNLTRYGKELSMVKIPSK 418
Cdd:TIGR00867 451 RLIIAKCGC------ADPRFPVPEGTRHCQAFnktDRECLetltgdlgeLHHSIFKCRCQQPCQESIYTTTYSAAKWPSG 524
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378744190  419 ASAKYLAKKFNKSE----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLE 486
Cdd:TIGR00867 525 SLKITLGSCDSNTAsecnEYYRENAAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQLGLWLGASVITVCE 596
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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