RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379698839   112 ARGLVREAREDLEVHQAKLKEVRDRLDRVSREDSQylelaTLEHRMLQEEKRLRTAYLRA---EDSEREKfslfSAAVRE 188
Cdd:TIGR02169  175 ALEELEEVEENIERLDLIIDEKRQQLERLRREREK-----AERYQALLKEKREYEGYELLkekEALERQK----EAIERQ 245

                           90
                   ....*....|...
gi 379698839   189 SHEKERTRAERTK 201
Cdd:TIGR02169  246 LASLEEELEKLTE 258

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379698839   112 ARGLVREAREDLEVHQAKLKEVRDRLDRVSREDSQylelaTLEHRMLQEEKRLRTAYLRA---EDSEREKfslfSAAVRE 188
Cdd:TIGR02169  175 ALEELEEVEENIERLDLIIDEKRQQLERLRREREK-----AERYQALLKEKREYEGYELLkekEALERQK----EAIERQ 245

                           90
                   ....*....|...
gi 379698839   189 SHEKERTRAERTK 201
Cdd:TIGR02169  246 LASLEEELEKLTE 258

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379698839   112 ARGLVREAREDLEVHQAKLKEVRDRLDRVSREDSQylelaTLEHRMLQEEKRLRTAYLRA---EDSEREKfslfSAAVRE 188
Cdd:TIGR02169  175 ALEELEEVEENIERLDLIIDEKRQQLERLRREREK-----AERYQALLKEKREYEGYELLkekEALERQK----EAIERQ 245

                           90
                   ....*....|...
gi 379698839   189 SHEKERTRAERTK 201
Cdd:TIGR02169  246 LASLEEELEKLTE 258