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Conserved domains on  [gi|384551672|ref|NP_001245144|]
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interleukin-12 receptor subunit beta-2 isoform c precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig super family cl05692
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.50e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


The actual alignment was detected with superfamily member pfam06328:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551672  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-529 5.19e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNwlrsrpynvsaliseipyRVSQNSHPINSL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT------------------PGSETSYTLTGL 64

                         90       100
                 ....*....|....*....|....*..
gi 384551672 503 QPRVTYVLWMTALTAAGESSHGNEREF 529
Cdd:cd00063   65 KPGTEYEFRVRAVNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 6.67e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 6.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551672 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.50e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551672  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-529 5.19e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNwlrsrpynvsaliseipyRVSQNSHPINSL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT------------------PGSETSYTLTGL 64

                         90       100
                 ....*....|....*....|....*..
gi 384551672 503 QPRVTYVLWMTALTAAGESSHGNEREF 529
Cdd:cd00063   65 KPGTEYEFRVRAVNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 6.67e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 6.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551672 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
423-521 1.61e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672  423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWlrsrpYNVSAliseipyrvSQNSHPINSL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNE-----ITVPG---------TTTSVTLTGL 63

                          90
                  ....*....|....*....
gi 384551672  503 QPRVTYVLWMTALTAAGES 521
Cdd:pfam00041  64 KPGTEYEVRVQAVNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-521 6.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 6.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672   423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELHPGGDTQVplnwlrsrpynvsaliSEIPYRVSQNSHPINSL 502
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEW----------------KEVNVTPSSTSYTLTGL 64

                           90
                   ....*....|....*....
gi 384551672   503 QPRVTYVLWMTALTAAGES 521
Cdd:smart00060  65 KPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.36e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.36e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384551672   224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 2.06e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384551672  256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.50e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551672  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-529 5.19e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNwlrsrpynvsaliseipyRVSQNSHPINSL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVT------------------PGSETSYTLTGL 64

                         90       100
                 ....*....|....*....|....*..
gi 384551672 503 QPRVTYVLWMTALTAAGESSHGNEREF 529
Cdd:cd00063   65 KPGTEYEFRVRAVNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 6.67e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 6.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551672 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
423-521 1.61e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672  423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWlrsrpYNVSAliseipyrvSQNSHPINSL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNE-----ITVPG---------TTTSVTLTGL 63

                          90
                  ....*....|....*....
gi 384551672  503 QPRVTYVLWMTALTAAGES 521
Cdd:pfam00041  64 KPGTEYEVRVQAVNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-521 6.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 6.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551672   423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELHPGGDTQVplnwlrsrpynvsaliSEIPYRVSQNSHPINSL 502
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEW----------------KEVNVTPSSTSYTLTGL 64

                           90
                   ....*....|....*....
gi 384551672   503 QPRVTYVLWMTALTAAGES 521
Cdd:smart00060  65 KPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.36e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.36e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384551672   224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 2.06e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384551672  256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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