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Conserved domains on  [gi|384551674|ref|NP_001245145|]
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interleukin-12 receptor subunit beta-2 isoform d precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig super family cl05692
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.38e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


The actual alignment was detected with superfamily member pfam06328:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551674  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.42e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                 ....*....
gi 384551674 503 SGDQGGCSS 511
Cdd:cd00063   78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 4.10e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 4.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551674 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
368-608 2.99e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401  174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401  254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401  327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                 ....*...
gi 384551674 601 LTAAGESS 608
Cdd:COG3401  400 VDAAGNES 407
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.38e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551674  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.42e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                 ....*....
gi 384551674 503 SGDQGGCSS 511
Cdd:cd00063   78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 4.10e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 4.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551674 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
368-608 2.99e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401  174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401  254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401  327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                 ....*...
gi 384551674 601 LTAAGESS 608
Cdd:COG3401  400 VDAAGNES 407
fn3 pfam00041
Fibronectin type III domain;
423-511 4.56e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 4.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674  423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWLRSRPYNVSALISeNIKSYICYEIRVYAL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 384551674  503 SGDQGGCSS 511
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 521-615 5.94e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 5.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 521 PLSGPHINAITEEKGSILISWNsiPVQEQMGCLLHYRIYWKERDSnSQPQLCEIPyRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGS-GDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 384551674 601 LTAAGESSHGNEREF 615
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 521-607 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   521 PLSGPHINAITEEKGSILISWNSiPVQEQMGcllHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEP-PPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 384551674   601 LTAAGES 607
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
521-607 1.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674  521 PLSGPHINAITEekGSILISWNsiPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYrvSQNSHPINSLQPRVTYVLWMTA 600
Cdd:pfam00041   2 APSNLTVTDVTS--TSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQA 75


                  ....*..
gi 384551674  601 LTAAGES 607
Cdd:pfam00041  76 VNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384551674   224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 1.65e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384551674  256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-508 8.72e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 8.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELhpggDTQVPLNWLR-SRPYNVSALISENIKSYICYEIRVYA 501
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVE----YREEGSEWKEvNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 384551674   502 LSGDQGG 508
Cdd:smart00060  77 VNGAGEG 83
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 3.38e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.65  E-value: 3.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 384551674  100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.42e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                 ....*....
gi 384551674 503 SGDQGGCSS 511
Cdd:cd00063   78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 4.10e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 4.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063    1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 384551674 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
368-608 2.99e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401  174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401  254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401  327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                 ....*...
gi 384551674 601 LTAAGESS 608
Cdd:COG3401  400 VDAAGNES 407
fn3 pfam00041
Fibronectin type III domain;
423-511 4.56e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 4.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674  423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWLRSRPYNVSALISeNIKSYICYEIRVYAL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 384551674  503 SGDQGGCSS 511
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 521-615 5.94e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 5.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674 521 PLSGPHINAITEEKGSILISWNsiPVQEQMGCLLHYRIYWKERDSnSQPQLCEIPyRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGS-GDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 384551674 601 LTAAGESSHGNEREF 615
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 521-607 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   521 PLSGPHINAITEEKGSILISWNSiPVQEQMGcllHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEP-PPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 384551674   601 LTAAGES 607
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
521-607 1.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674  521 PLSGPHINAITEekGSILISWNsiPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYrvSQNSHPINSLQPRVTYVLWMTA 600
Cdd:pfam00041   2 APSNLTVTDVTS--TSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQA 75


                  ....*..
gi 384551674  601 LTAAGES 607
Cdd:pfam00041  76 VNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384551674   224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 1.65e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384551674  256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-508 8.72e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 8.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551674   423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELhpggDTQVPLNWLR-SRPYNVSALISENIKSYICYEIRVYA 501
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVE----YREEGSEWKEvNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 384551674   502 LSGDQGG 508
Cdd:smart00060  77 VNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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