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Conserved domains on  [gi|389885061|ref|NP_001254514|]
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F-box/WD repeat-containing protein 10 isoform 1 [Homo sapiens]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 17778652)

F-box/WD repeat-containing protein functions as the substrate-recognition component of a SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|2.130.10.10
Gene Ontology:  GO:0019005|GO:0005515|GO:0016567|GO:0006511
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-653 2.38e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.50  E-value: 2.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200    96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNC 647
Cdd:cd00200   176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC 253


                  ....*.
gi 389885061  648 MKVLKA 653
Cdd:cd00200   254 VQTLSG 259
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.04e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.67  E-value: 9.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 389885061  277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136     1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-653 2.38e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.50  E-value: 2.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200    96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNC 647
Cdd:cd00200   176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC 253


                  ....*.
gi 389885061  648 MKVLKA 653
Cdd:cd00200   254 VQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
422-671 8.73e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 8.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  422 GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319   211 AFSPDgkLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  577 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllF----LRVISACADGKIRIYNFLNGNCMK 649
Cdd:COG2319   291 VNSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FspdgKTLASGSDDGTVRLWDLATGELLR 366

                         250       260
                  ....*....|....*....|....
gi 389885061  650 VLKanGRGDPV--LSFFIQGNRMV 671
Cdd:COG2319   367 TLT--GHTGAVtsVAFSPDGRTLA 388
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.04e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.67  E-value: 9.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 389885061  277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136     1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 484-521 7.79e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 7.79e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 389885061    484 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 521
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
485-521 4.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.75e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 389885061   485 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-653 2.38e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.50  E-value: 2.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200    96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSLLFLR--VISACADGKIRIYNFLNGNC 647
Cdd:cd00200   176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC 253


                  ....*.
gi 389885061  648 MKVLKA 653
Cdd:cd00200   254 VQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-672 1.03e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTG 525
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  526 KCLKTFR-HKDPILATRIN-DTYIVSSCER-GLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:cd00200    84 ECVRTLTgHTSYVSSVAFSpDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 389885061  601 MvgKYERCLMAFK-HPKEVLDVSLL--FLRVISACADGKIRIYNFLNGNCMKVLKanGRGDPVLSF-FIQGNRMVV 672
Cdd:cd00200   164 L--RTGKCVATLTgHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLR--GHENGVNSVaFSPDGYLLA 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-641 3.04e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 3.04e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  425 LIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITC--MD 502
Cdd:cd00200    66 LASGSSDKTIRLWDLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSvaFS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  503 LCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKC 579
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 389885061  580 LFFDQWHLL--SGSTDGLVMAWSMVGKyeRCLMAFK-HPKEV--LDVSLLFLRVISACADGKIRIYN 641
Cdd:cd00200   225 VAFSPDGYLlaSGSEDGTIRVWDLRTG--ECVQTLSgHTNSVtsLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
422-671 8.73e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 8.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  422 GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319   211 AFSPDgkLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  577 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllF----LRVISACADGKIRIYNFLNGNCMK 649
Cdd:COG2319   291 VNSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FspdgKTLASGSDDGTVRLWDLATGELLR 366

                         250       260
                  ....*....|....*....|....
gi 389885061  650 VLKanGRGDPV--LSFFIQGNRMV 671
Cdd:COG2319   367 TLT--GHTGAVtsVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-600 2.47e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 2.47e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  418 IHYSGGDLIAVSSNR--KIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQ 495
Cdd:cd00200    99 VAFSPDGRILSSSSRdkTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  496 GTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-DTYIVSSC-ERGLVKVWHIAMAQLVKTL 570
Cdd:cd00200   178 GEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSpDGYLLASGsEDGTIRVWDLRTGECVQTL 257

                         170       180       190
                  ....*....|....*....|....*....|..
gi 389885061  571 SGHEGAVKCLFFDQW--HLLSGSTDGLVMAWS 600
Cdd:cd00200   258 SGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
405-662 1.90e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  405 VRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQvKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKS 484
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  485 GVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVW 559
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFspDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  560 HIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFKHPK-EVLDVSllFL----RVISAC 632
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSgGVNSVA--FSpdgkLLASGS 307

                         250       260       270
                  ....*....|....*....|....*....|
gi 389885061  633 ADGKIRIYNFLNGNCMKVLKanGRGDPVLS 662
Cdd:COG2319   308 DDGTVRLWDLATGKLLRTLT--GHTGAVRS 335
WD40 COG2319
WD40 repeat [General function prediction only];
423-641 1.04e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  423 GDLIAVSS-NRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   174 GKLLASGSdDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319   253 AFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 389885061  577 VKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACADGKIRIYN 641
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATG--ELLRTLTgHTGAVTSVA--FSpdgrTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
406-662 6.73e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 6.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  406 RILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSG 485
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  486 VCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWH 560
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  561 IAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACA 633
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATG--KLLRTLTgHSGSVRSVA--FSpdgrLLASGSA 266

                         250       260
                  ....*....|....*....|....*....
gi 389885061  634 DGKIRIYNFLNGNCMKVLKanGRGDPVLS 662
Cdd:COG2319   267 DGTVRLWDLATGELLRTLT--GHSGGVNS 293
WD40 COG2319
WD40 repeat [General function prediction only];
423-601 6.99e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 6.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  423 GDLIAVSS-NRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   216 GKLLASGSaDGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319   295 AFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                         170       180
                  ....*....|....*....|....*..
gi 389885061  577 VKCLFFDQW--HLLSGSTDGLVMAWSM 601
Cdd:COG2319   375 VTSVAFSPDgrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 487-681 3.05e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 3.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  487 CTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHI 561
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  562 AMAQLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWSMvgKYERCLMAFK-HPKEVLDVSLLF--LRVISACADGK 636
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDV--ETGKCLTTLRgHTDWVNSVAFSPdgTFVASSSQDGT 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 389885061  637 IRIYNFLNGNCMKVLKanGRGDPV--LSFFIQGNRMVVNTESNVLMF 681
Cdd:cd00200   159 IKLWDLRTGKCVATLT--GHTGEVnsVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
423-662 5.60e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 5.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM- 501
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVa 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  502 -DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAV 577
Cdd:COG2319    86 fSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  578 KCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFK-HPKEVLDVSllFL----RVISACADGKIRIYNFLNGNCMKV 650
Cdd:COG2319   166 TSVAFspDGKLLASGSDDGTVRLWDLATG--KLLRTLTgHTGAVRSVA--FSpdgkLLASGSADGTVRLWDLATGKLLRT 241

                         250
                  ....*....|..
gi 389885061  651 LKanGRGDPVLS 662
Cdd:COG2319   242 LT--GHSGSVRS 251
WD40 COG2319
WD40 repeat [General function prediction only];
423-562 8.66e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 8.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  423 GDLIAVSS-NRKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   258 GRLLASGSaDGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCERGLVKVWHIA 562
Cdd:COG2319   337 AFSPDgkTLASGSDDGTVRLWDLATGELLRTLTgHTGAVtsVAFSPDGRTLASGSADGTVRLWDLA 402
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.04e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.67  E-value: 9.04e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 389885061  277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136     1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
WD40 COG2319
WD40 repeat [General function prediction only];
423-524 4.77e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  423 GDLIAVSSN-RKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319   300 GKLLASGSDdGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                          90       100
                  ....*....|....*....|....*
gi 389885061  502 DLCKN--RLVSGGRDCQVKVWDVDT 524
Cdd:COG2319   379 AFSPDgrTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 484-521 7.79e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 7.79e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 389885061    484 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 521
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 276-312 1.15e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 46.17  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 389885061  276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMA 312
Cdd:cd22131     1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVI 37
WD40 pfam00400
WD domain, G-beta repeat;
485-521 4.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.75e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 389885061   485 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 276-314 5.07e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 41.63  E-value: 5.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 389885061  276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQ 314
Cdd:cd22173     1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQ 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-600 9.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 9.56e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 389885061    565 QLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
405-484 2.19e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885061  405 VRILSDTWDQNRVIHYS--GGDLIAVSSNRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDL 482
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401


                  ..
gi 389885061  483 KS 484
Cdd:COG2319   402 AT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 448-481 3.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.27e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 389885061    448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
Cdd:smart00320    7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
448-481 4.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 4.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 389885061   448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 276-308 5.51e-04

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 38.80  E-value: 5.51e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 389885061  276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHW 308
Cdd:cd22172     4 DFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYW 36
WD40 pfam00400
WD domain, G-beta repeat;
565-600 1.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 389885061   565 QLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWS 600
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 276-314 1.71e-03

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 37.43  E-value: 1.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 389885061  276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQ 314
Cdd:cd22094     1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCES 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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