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Conserved domains on  [gi|390131988|ref|NP_001254523|]
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sentrin-specific protease 1 [Homo sapiens]

Protein Classification

C48 family peptidase( domain architecture ID 581147)

C48 family peptidase similar to sentrin-specific proteases (SUMO proteases) that catalyze the processing of small ubiquitin-like modifier (SUMO) propeptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_C48 super family cl23802
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
420-642 3.30e-49

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


The actual alignment was detected with superfamily member PLN03189:

Pssm-ID: 420019 [Multi-domain]  Cd Length: 490  Bit Score: 178.89  E-value: 3.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 420 FPEITEEMEKEIKNVFRNGNQDEVLS--EAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKE--KGLPSVHAFNT 495
Cdd:PLN03189 256 FIPLTREEETEVKRAFSANNRRKVLVthENSNIDITGEILRCLKPGAWLNDEVINLYLELLKEREARepKKFLKCHFFNT 335
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 496 FFFTKLKTAG----YQAVKRWT--KKVDVF--SVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYL 567
Cdd:PLN03189 336 FFYKKLVSGKsgydYKAVRRWTtqKKLGYHliDCDKIFVPIHQEIHWTLAVINKKDQKFQYLDSLKGRDPKILDALAKYY 415
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 390131988 568 KQESIDKKRKEFDTNGWQLfsKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRK 642
Cdd:PLN03189 416 VDEVKDKSEKDIDVSSWEQ--EFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQEHMPYFRLRTAKEILRLK 488
 
Name Accession Description Interval E-value
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
420-642 3.30e-49

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 178.89  E-value: 3.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 420 FPEITEEMEKEIKNVFRNGNQDEVLS--EAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKE--KGLPSVHAFNT 495
Cdd:PLN03189 256 FIPLTREEETEVKRAFSANNRRKVLVthENSNIDITGEILRCLKPGAWLNDEVINLYLELLKEREARepKKFLKCHFFNT 335
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 496 FFFTKLKTAG----YQAVKRWT--KKVDVF--SVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYL 567
Cdd:PLN03189 336 FFYKKLVSGKsgydYKAVRRWTtqKKLGYHliDCDKIFVPIHQEIHWTLAVINKKDQKFQYLDSLKGRDPKILDALAKYY 415
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 390131988 568 KQESIDKKRKEFDTNGWQLfsKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRK 642
Cdd:PLN03189 416 VDEVKDKSEKDIDVSSWEQ--EFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQEHMPYFRLRTAKEILRLK 488
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
464-643 4.23e-47

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 164.55  E-value: 4.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988  464 NWLNDEIINFYMNMLMER--SKEKGLPSVHAFNTFFFTKL----------KTAGYQAVKRWTKKV--DVFSVDILLVPIH 529
Cdd:pfam02902   1 EWLNDTVIDFYLKLLAHRleSEDYKNERVHFLNSFFYSKLtskvsfkwgkKKDFYNGVRRWTRKNkkWLFDVDIIYIPIN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988  530 L-GVHWCLAVVDFRKKNITYYDSMGGINNEACRI-----LLQYLKQESIDKKRKEFDTNGWQLFSKksQEIPQQMNGSDC 603
Cdd:pfam02902  81 WdGKHWVLLIINLPKKTITILDSLISLHTDKEYIrpinaMLPYLMSEALKKEQDDPDLTPFEIKRL--TKVPQQPNSGDC 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 390131988  604 GMFACKYADCITKDRPINFTQ-QHMPYFRKRM---VWEILHRKL 643
Cdd:pfam02902 159 GPYVLKFIELLAEGVPFEFLTeKDVDRFRKKLavdIYEILLSRL 202
ULP1 COG5160
Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones];
464-624 5.96e-11

Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444062  Cd Length: 296  Bit Score: 63.90  E-value: 5.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 464 NWLNDEIINFYMNMLMER-SKEKGLPsvHAFNTFFFTKLKTAGYQAVKRwtKKVDVFSVDILLVPIHL-GVHWCLAVVDF 541
Cdd:COG5160  108 NWLNDQHLGAYSLFLAERlQPNAFLL--FFAWTYVVPGLTDRFQKEDAY--HILDVRAKPIIFLPLNIpNNHWSLLVVDR 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 542 RKKNITYYDSMggINNEACRILLQYLKqesiDKKRKE---FDTNGWQLFSKKSQEIP--QQMNGSDCGMFACKYADCITK 616
Cdd:COG5160  184 RNRDAVYYDSL--YNYVSPEDMEQDLQ----DFAQYLlqvDPAYDSQKFYTKIAAKPvaQQPDGYSCGDWVLQFLEWYLR 257

                 ....*...
gi 390131988 617 DRPINFTQ 624
Cdd:COG5160  258 DPFTDLND 265
 
Name Accession Description Interval E-value
PLN03189 PLN03189
Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
420-642 3.30e-49

Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional


Pssm-ID: 215622 [Multi-domain]  Cd Length: 490  Bit Score: 178.89  E-value: 3.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 420 FPEITEEMEKEIKNVFRNGNQDEVLS--EAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKE--KGLPSVHAFNT 495
Cdd:PLN03189 256 FIPLTREEETEVKRAFSANNRRKVLVthENSNIDITGEILRCLKPGAWLNDEVINLYLELLKEREARepKKFLKCHFFNT 335
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 496 FFFTKLKTAG----YQAVKRWT--KKVDVF--SVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYL 567
Cdd:PLN03189 336 FFYKKLVSGKsgydYKAVRRWTtqKKLGYHliDCDKIFVPIHQEIHWTLAVINKKDQKFQYLDSLKGRDPKILDALAKYY 415
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 390131988 568 KQESIDKKRKEFDTNGWQLfsKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRK 642
Cdd:PLN03189 416 VDEVKDKSEKDIDVSSWEQ--EFVEDLPEQKNGYDCGMFMIKYIDFYSRGLGLCFGQEHMPYFRLRTAKEILRLK 488
Peptidase_C48 pfam02902
Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad ...
464-643 4.23e-47

Ulp1 protease family, C-terminal catalytic domain; This domain contains the catalytic triad Cys-His-Asn.


Pssm-ID: 397169  Cd Length: 202  Bit Score: 164.55  E-value: 4.23e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988  464 NWLNDEIINFYMNMLMER--SKEKGLPSVHAFNTFFFTKL----------KTAGYQAVKRWTKKV--DVFSVDILLVPIH 529
Cdd:pfam02902   1 EWLNDTVIDFYLKLLAHRleSEDYKNERVHFLNSFFYSKLtskvsfkwgkKKDFYNGVRRWTRKNkkWLFDVDIIYIPIN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988  530 L-GVHWCLAVVDFRKKNITYYDSMGGINNEACRI-----LLQYLKQESIDKKRKEFDTNGWQLFSKksQEIPQQMNGSDC 603
Cdd:pfam02902  81 WdGKHWVLLIINLPKKTITILDSLISLHTDKEYIrpinaMLPYLMSEALKKEQDDPDLTPFEIKRL--TKVPQQPNSGDC 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 390131988  604 GMFACKYADCITKDRPINFTQ-QHMPYFRKRM---VWEILHRKL 643
Cdd:pfam02902 159 GPYVLKFIELLAEGVPFEFLTeKDVDRFRKKLavdIYEILLSRL 202
ULP1 COG5160
Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones];
464-624 5.96e-11

Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444062  Cd Length: 296  Bit Score: 63.90  E-value: 5.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 464 NWLNDEIINFYMNMLMER-SKEKGLPsvHAFNTFFFTKLKTAGYQAVKRwtKKVDVFSVDILLVPIHL-GVHWCLAVVDF 541
Cdd:COG5160  108 NWLNDQHLGAYSLFLAERlQPNAFLL--FFAWTYVVPGLTDRFQKEDAY--HILDVRAKPIIFLPLNIpNNHWSLLVVDR 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390131988 542 RKKNITYYDSMggINNEACRILLQYLKqesiDKKRKE---FDTNGWQLFSKKSQEIP--QQMNGSDCGMFACKYADCITK 616
Cdd:COG5160  184 RNRDAVYYDSL--YNYVSPEDMEQDLQ----DFAQYLlqvDPAYDSQKFYTKIAAKPvaQQPDGYSCGDWVLQFLEWYLR 257

                 ....*...
gi 390131988 617 DRPINFTQ 624
Cdd:COG5160  258 DPFTDLND 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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