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Conserved domains on  [gi|1653961588|ref|NP_001256|]
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homeobox protein CDX-2 isoform 1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11152543)

homeobox domain-containing protein similar to double homeobox protein that may act as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 6.10e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


:

Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 107.91  E-value: 6.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 1653961588 173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain pfam00046
Homeodomain;
188-243 1.34e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.34e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653961588 188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 243
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 6.10e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 107.91  E-value: 6.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 1653961588 173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain pfam00046
Homeodomain;
188-243 1.34e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.34e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653961588 188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 243
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 188-242 4.00e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 4.00e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1653961588  188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKER 242
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 188-243 9.35e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 9.35e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653961588 188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 243
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
178-248 2.30e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 2.30e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653961588 178 GSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKK 248
Cdd:COG5576    43 RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGK 113
 
Name Accession Description Interval E-value
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-179 6.10e-29

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 107.91  E-value: 6.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  13 MYPSSVRHSGgLNLAPQNFVSPPQYPDYGGYHvaaaaaAAANLDSAQSPGPSWPAAYGAPlREDWNgyaPGGAAAAANAV 92
Cdd:pfam04731   1 MYPGSVRHPG-LNLPAQNFVAPPQYSDYMGYH------HVPGMDPHGQSLGAWGSPYGPP-REDWN---AYGPGPSSTVG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653961588  93 AHGLNGGSPaAAMGYsSPADYhphhhphhhPHHPAAAPSCASGLLQTLNpgppgpaatAAAEQLSPGGQRRNLCEWMRKP 172
Cdd:pfam04731  70 TAPMNDASP-GQIAY-SPPDY---------SSLHPPGPSSGLSLPPPLN---------SSLEQLSPSRQRRSPYEWMRKT 129


                  ....*..
gi 1653961588 173 AQQSLGS 179
Cdd:pfam04731 130 VQVTSKG 136
Homeodomain pfam00046
Homeodomain;
188-243 1.34e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.34e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653961588 188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 243
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 188-242 4.00e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 4.00e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1653961588  188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKER 242
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 188-243 9.35e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 9.35e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653961588 188 KYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERK 243
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
178-248 2.30e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 2.30e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653961588 178 GSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKK 248
Cdd:COG5576    43 RKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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