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Conserved domains on  [gi|393537072|ref|NP_001257326|]
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glucose-6-phosphatase catalytic subunit 1 isoform 2 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
42-114 4.94e-39

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03381:

Pssm-ID: 444927  Cd Length: 235  Bit Score: 132.89  E-value: 4.94e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 393537072  42 AFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPG 114
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSSVPKIEQFPLTCETGPG 73
 
Name Accession Description Interval E-value
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
42-114 4.94e-39

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 132.89  E-value: 4.94e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 393537072  42 AFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPG 114
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSSVPKIEQFPLTCETGPG 73
acidPPc smart00014
Acid phosphatase homologues;
62-114 7.08e-04

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 37.71  E-value: 7.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 393537072    62 LWVAVIGDWLNLVFKWILFGQRPYWWvldtdyySNTSVPLIKQFPVTCETGPG 114
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL-------SIGDACCTPNFLLTLEAGYS 46
 
Name Accession Description Interval E-value
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
42-114 4.94e-39

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 132.89  E-value: 4.94e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 393537072  42 AFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPG 114
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSSVPKIEQFPLTCETGPG 73
acidPPc smart00014
Acid phosphatase homologues;
62-114 7.08e-04

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 37.71  E-value: 7.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 393537072    62 LWVAVIGDWLNLVFKWILFGQRPYWWvldtdyySNTSVPLIKQFPVTCETGPG 114
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL-------SIGDACCTPNFLLTLEAGYS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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