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Conserved domains on  [gi|395132436|ref|NP_001257419|]
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large ribosomal subunit protein eL18 isoform 2 [Homo sapiens]

Protein Classification

eL18 family ribosomal protein( domain architecture ID 12181919)

eL18 family ribosomal protein is a component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Gene Ontology:  GO:0005840|GO:0006412|GO:0003735
PubMed:  24524803

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-147 4.25e-99

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


:

Pssm-ID: 465358  Cd Length: 184  Bit Score: 282.92  E-value: 4.25e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436    2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRAR 81
Cdd:pfam17135  27 LYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAVVVGTVTDDVRLLEVPKLSVCALRFTETAR 106
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 395132436   82 SRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFER 147
Cdd:pfam17135 107 ARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHSHTKPYVRSKGRKFER 172
 
Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-147 4.25e-99

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


Pssm-ID: 465358  Cd Length: 184  Bit Score: 282.92  E-value: 4.25e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436    2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRAR 81
Cdd:pfam17135  27 LYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAVVVGTVTDDVRLLEVPKLSVCALRFTETAR 106
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 395132436   82 SRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFER 147
Cdd:pfam17135 107 ARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHSHTKPYVRSKGRKFER 172
PTZ00469 PTZ00469
60S ribosomal subunit protein L18; Provisional
2-158 2.88e-46

60S ribosomal subunit protein L18; Provisional


Pssm-ID: 185648  Cd Length: 187  Bit Score: 149.04  E-value: 2.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRAR 81
Cdd:PTZ00469  32 LYRFLARRTNANFNKIIAKRLIMPKRFRPPLSLSKLHRHMA--SYPDDVAVVVGSITDDKRLYDCKKLKVCALRFTETAR 109
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395132436  82 SRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYK 158
Cdd:PTZ00469 110 KRILDAGGECLTFDQLALKYPTGQKCILLRGPTKARTAEKHFGKAPGRPKSKARPYVRSKGRKFEKARGRRKSRAYK 186
RPL18A COG1727
Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
7-110 7.05e-07

Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441333  Cd Length: 114  Bit Score: 45.57  E-value: 7.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   7 ARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVV------VGTITDdvrvqevpKLKVCALRVTSRA 80
Cdd:COG1727   17 SRENDAPIWRDVAERLEKPRRNRAEVNLSKINRYAK----EGDTVVVpgkvlgSGKLSK--------KVTVAAFSFSETA 84
                         90       100       110
                 ....*....|....*....|....*....|
gi 395132436  81 RSRILRAGGKILTFDQLALDSPKGCGTVLL 110
Cdd:COG1727   85 AEKIEEAGGECLTIEELVKENPKGSGVRII 114
 
Name Accession Description Interval E-value
Ribosomal_L18 pfam17135
Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from ...
2-147 4.25e-99

Ribosomal protein 60S L18 and 50S L18e; This is a family of ribosomal proteins, 60S L18 from eukaryotes and 50S L18e from Archaea.


Pssm-ID: 465358  Cd Length: 184  Bit Score: 282.92  E-value: 4.25e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436    2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRAR 81
Cdd:pfam17135  27 LYRFLARRTDSKFNKVVLKRLFMSRINRPPLSLSRIARAMKKKGREGKIAVVVGTVTDDVRLLEVPKLSVCALRFTETAR 106
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 395132436   82 SRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFER 147
Cdd:pfam17135 107 ARILKAGGECLTFDQLALRAPTGKNTVLLRGPRNAREAVKHFGFAPGGPHSHTKPYVRSKGRKFER 172
PTZ00469 PTZ00469
60S ribosomal subunit protein L18; Provisional
2-158 2.88e-46

60S ribosomal subunit protein L18; Provisional


Pssm-ID: 185648  Cd Length: 187  Bit Score: 149.04  E-value: 2.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRAR 81
Cdd:PTZ00469  32 LYRFLARRTNANFNKIIAKRLIMPKRFRPPLSLSKLHRHMA--SYPDDVAVVVGSITDDKRLYDCKKLKVCALRFTETAR 109
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395132436  82 SRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYK 158
Cdd:PTZ00469 110 KRILDAGGECLTFDQLALKYPTGQKCILLRGPTKARTAEKHFGKAPGRPKSKARPYVRSKGRKFEKARGRRKSRAYK 186
PTZ00195 PTZ00195
60S ribosomal protein L18; Provisional
2-144 1.20e-43

60S ribosomal protein L18; Provisional


Pssm-ID: 140222  Cd Length: 198  Bit Score: 142.86  E-value: 1.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   2 LYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKL------PGRENKTAVVVGTITDDVRVQEVPKLKVCALR 75
Cdd:PTZ00195  32 LYKFLAKRTSSGFNKVVYQRLIKSRSNRAPISLSRIAVVMKRkavftaKGKKAPIAVVVGDVLDDVRMARIPAMRVCALR 111
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 395132436  76 VTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGkAPGTPHSHTKPYVRSKGRK 144
Cdd:PTZ00195 112 FSKSARQSIVAAGGECLTFDQLAMIAPTGKNTYLLRGRKSGRESVRHFG-ASGVPGSHSKPYATNRGKE 179
RPL18A COG1727
Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
7-110 7.05e-07

Ribosomal protein L18E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441333  Cd Length: 114  Bit Score: 45.57  E-value: 7.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   7 ARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVV------VGTITDdvrvqevpKLKVCALRVTSRA 80
Cdd:COG1727   17 SRENDAPIWRDVAERLEKPRRNRAEVNLSKINRYAK----EGDTVVVpgkvlgSGKLSK--------KVTVAAFSFSETA 84
                         90       100       110
                 ....*....|....*....|....*....|
gi 395132436  81 RSRILRAGGKILTFDQLALDSPKGCGTVLL 110
Cdd:COG1727   85 AEKIEEAGGECLTIEELVKENPKGSGVRII 114
PRK04005 PRK04005
50S ribosomal protein L18e; Provisional
1-110 9.88e-07

50S ribosomal protein L18e; Provisional


Pssm-ID: 235196  Cd Length: 111  Bit Score: 44.84  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395132436   1 MLYRFL---ARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKlpgrENKTAVV------VGTITDDVrvqevpklKV 71
Cdd:PRK04005   4 KLIRDLkkaSRENGAPIWKDVAERLEKPRRRRAEVNLSKINRYAK----EGDTVVVpgkvlgSGKLDHKV--------TV 71
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 395132436  72 CALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLL 110
Cdd:PRK04005  72 AALSFSETAKEKIEEAGGKALTIEELVEENPKGSNVRIM 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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