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Conserved domains on  [gi|398303848|ref|NP_001257691|]
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ribonuclease inhibitor isoform a [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-356 9.74e-114

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 338.56  E-value: 9.74e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  37 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 114
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 115 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 194
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 195 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 274
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 275 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 354
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 398303848 355 SL 356
Cdd:cd00116  318 SF 319
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 313-455 1.55e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.92  E-value: 1.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 313 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 392
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398303848 393 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 455
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-356 9.74e-114

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 338.56  E-value: 9.74e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  37 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 114
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 115 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 194
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 195 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 274
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 275 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 354
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 398303848 355 SL 356
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 259-454 2.91e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 107.95  E-value: 2.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 259 SLQELDLGSNKLGNTGIAALCSGLLLPScRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCES 338
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 339 LlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTvLRVLWLGDCDVTDSGC 418
Cdd:COG5238  260 L-KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGA 337

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 398303848 419 SSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLK 454
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 313-455 1.55e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.92  E-value: 1.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 313 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 392
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398303848 393 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 455
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 37-66 2.16e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 55.58  E-value: 2.16e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 398303848   37 MSLDIQCEQLSDARWTELLPLIQQYQVVRL 66
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 318-465 9.59e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 9.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 318 KELSLAGNELKDEGAQLLCESLLepgcQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALG 397
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLL----CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398303848 398 YPDTV-LRVLWLGDCDVTDSGCSSLATvLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVL 465
Cdd:cd00116   77 LTKGCgLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
143-170 1.08e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 42.01  E-value: 1.08e-05
                           10        20
                   ....*....|....*....|....*...
gi 398303848   143 LSTLRELHLNDNPLGDEGLKLLCEGLRD 170
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
428-455 2.70e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....*...
gi 398303848   428 NRSLRELDLSNNCMGDTGVLQLLESLKQ 455
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-356 9.74e-114

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 338.56  E-value: 9.74e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  37 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 114
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 115 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 194
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 195 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 274
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 275 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 354
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 398303848 355 SL 356
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 259-454 2.91e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 107.95  E-value: 2.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 259 SLQELDLGSNKLGNTGIAALCSGLLLPScRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCES 338
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 339 LlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTvLRVLWLGDCDVTDSGC 418
Cdd:COG5238  260 L-KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGA 337

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 398303848 419 SSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLK 454
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-302 1.24e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.09  E-value: 1.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848   4 GSRLPLRVFFGSLPGLLNTWQSVWTRRLHCAPTMSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAI 83
Cdd:COG5238  125 KTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEAL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  84 QANPALTELSLRTNELGDAGVGLVLQGLQNPTcKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKL 163
Cdd:COG5238  205 TQNTTVTTLWLKRNPIGDEGAEILAEALKGNK-SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIA 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 164 LCEGLRDPQcRLEKLQLEYCNLTATSCEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSAcQLESLKLENCGIT 243
Cdd:COG5238  284 LAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENT-TLHSLDLSDNQIG 361

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 398303848 244 SANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPscRLRTLWLWDCDVTAE 302
Cdd:COG5238  362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN--RLHTLILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-396 1.84e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 93.70  E-value: 1.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  92 LSLRTNELGDAGVGLVLQGLQNPTckIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLkllceglrdp 171
Cdd:COG5238  158 LLGLAARLGLLAAISMAKALQNNS--VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGA---------- 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 172 qcrleklqleycnltatscEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSAcQLESLKLENCGITSANCKDLC 251
Cdd:COG5238  226 -------------------EILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSGNQIGAEGAIALA 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 252 DVVASKASLQELDLGSNKLGNTGIAALCSGlLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEG 331
Cdd:COG5238  286 KALQGNTTLTSLDLSVNRIGDEGAIALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEG 364

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398303848 332 AQLLCESLLEpgcqleslwvktcsltaascphfcsvltkNRSLFELQMSSNPLGDSGVVELCKAL 396
Cdd:COG5238  365 AIALAKYLEG-----------------------------NTTLRELNLGKNNIGKQGAEALIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 313-455 1.55e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.92  E-value: 1.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 313 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 392
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398303848 393 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 455
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 363-457 5.20e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.59  E-value: 5.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 363 HFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVlRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMG 442
Cdd:COG5238  171 ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTV-TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIG 249

                         90
                 ....*....|....*
gi 398303848 443 DTGVLQLLESLKQPS 457
Cdd:COG5238  250 DEGVIALAEALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 38-226 2.48e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 65.58  E-value: 2.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  38 SLDIQCEQLSDARWTELLP-LIQQYQVVRLDDCG--LTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNp 114
Cdd:COG5238  240 TLDLSNNQIGDEGVIALAEaLKNNTTVETLYLSGnqIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG- 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 115 TCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQcRLEKLQLEYCNLTATSCEPLA 194
Cdd:COG5238  319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEALI 397

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 398303848 195 SVLrVKPDFKELVLSNNDFH---EAGIHTLCQGLK 226
Cdd:COG5238  398 DAL-QTNRLHTLILDGNLIGaeaQQRLEQLLERIK 431
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 37-66 2.16e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 55.58  E-value: 2.16e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 398303848   37 MSLDIQCEQLSDARWTELLPLIQQYQVVRL 66
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 318-465 9.59e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 9.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 318 KELSLAGNELKDEGAQLLCESLLepgcQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALG 397
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLL----CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398303848 398 YPDTV-LRVLWLGDCDVTDSGCSSLATvLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVL 465
Cdd:cd00116   77 LTKGCgLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-286 5.53e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 5.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  77 KDIRSAIQANPALTELSLRTNELGDagVGLVLQGLQNptckIQKLSLQNCSLTEagcgvLPDVLRSLSTLRELHLNDNPL 156
Cdd:COG4886  126 TDLPEELANLTNLKELDLSNNQLTD--LPEPLGNLTN----LKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 157 GDEGLKLlcEGLRdpqcRLEKLQLEYCNLTAtscepLASVLRVKPDFKELVLSNNDFHEagIHTLCQgLKdsacQLESLK 236
Cdd:COG4886  195 TDLPEPL--GNLT----NLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTD--LPELGN-LT----NLEELD 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 398303848 237 LENCGITSAnckdlcDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPS 286
Cdd:COG4886  257 LSNNQLTDL------PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
143-170 1.08e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 42.01  E-value: 1.08e-05
                           10        20
                   ....*....|....*....|....*...
gi 398303848   143 LSTLRELHLNDNPLGDEGLKLLCEGLRD 170
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-272 1.42e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848  38 SLDIQCEQLSDarWTELLPLIQQYQVVRLDDCGLTevrckDIRSAIQANPALTELSLRTNELGDagVGLVLQGLQNptck 117
Cdd:COG4886  117 SLDLSGNQLTD--LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLTN---- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 118 IQKLSLQNCSLTEagcgvLPDVLRSLSTLRELHLNDNPLGDEGLKLlcEGLRdpqcRLEKLQLEYCNLTatSCEPLASVl 197
Cdd:COG4886  184 LKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPEPL--ANLT----NLETLDLSNNQLT--DLPELGNL- 249

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398303848 198 rvkPDFKELVLSNNDFheagihtlcQGLKDSAC--QLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGN 272
Cdd:COG4886  250 ---TNLEELDLSNNQL---------TDLPPLANltNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
231-468 9.70e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 9.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 231 QLESLKLENCGITsanckDLCDVVASKASLQELDLGSNKLgnTGIAALCSGLLlpscRLRTLWLWDCDVTaegckDLCRV 310
Cdd:COG4886  114 NLESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQL--TDLPEPLGNLT----NLKSLDLSNNQLT-----DLPEE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398303848 311 LRAKQSLKELSLAGNELKDEGAQLlcESLlepgCQLESLWVKTCSLTAASCPhfcsvLTKNRSLFELQMSSNPLGDsgVV 390
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPEPL--GNL----TNLEELDLSGNQLTDLPEP-----LANLTNLETLDLSNNQLTD--LP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398303848 391 ELCKAlgypdTVLRVLWLGDCDVTDsgcsslATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVLYDI 468
Cdd:COG4886  245 ELGNL-----TNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
428-455 2.70e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.70e-04
                           10        20
                   ....*....|....*....|....*...
gi 398303848   428 NRSLRELDLSNNCMGDTGVLQLLESLKQ 455
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
371-396 1.34e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|....*.
gi 398303848   371 NRSLFELQMSSNPLGDSGVVELCKAL 396
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
286-313 1.69e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.85  E-value: 1.69e-03
                           10        20
                   ....*....|....*....|....*...
gi 398303848   286 SCRLRTLWLWDCDVTAEGCKDLCRVLRA 313
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
200-227 4.14e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 4.14e-03
                           10        20
                   ....*....|....*....|....*...
gi 398303848   200 KPDFKELVLSNNDFHEAGIHTLCQGLKD 227
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
314-339 8.40e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 33.92  E-value: 8.40e-03
                           10        20
                   ....*....|....*....|....*.
gi 398303848   314 KQSLKELSLAGNELKDEGAQLLCESL 339
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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