NCBI Conserved Domain Search

Conserved domains on [gi|402478636|ref|NP_001257954|]

View

1,5-anhydro-D-fructose reductase isoform 3 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

AKR_SF super family

cl00470

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...

1-222

1.98e-144

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.

The actual alignment was detected with superfamily member cd19110:

Pssm-ID: 444925 [Multi-domain] Cd Length: 301 Bit Score: 404.73 E-value: 1.98e-144

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWE------- 153
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEamedlvi 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636     --------------------------------------------------------------------------------
Cdd:cd19110  142 eglvknigvsnfnheqlerllnkpglrvkpvtnqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 154 -----------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 222
Cdd:cd19110  222 iakkhgkspaqILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301

Name

Accession

Description

Interval

E-value

AKR_AKR1E1-2

cd19110

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...

1-222

1.98e-144

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.

Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 404.73 E-value: 1.98e-144

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWE------- 153
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEamedlvi 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636     --------------------------------------------------------------------------------
Cdd:cd19110  142 eglvknigvsnfnheqlerllnkpglrvkpvtnqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 154 -----------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 222
Cdd:cd19110  222 iakkhgkspaqILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

4-208

6.10e-65

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 201.44 E-value: 6.10e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:COG0656    5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHGYDDTLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMG--------------------------FKPPHPEWIMSCS---------ELsfclsHP 128
Cdd:COG0656   81 FEESLERLGLDYLDLYLIHWPGPgpyvetwraleelyeegliraigvsnFDPEHLEELLAETgvkpavnqvEL-----HP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 129 RVQDLPL----DESNMVI----P-SDTDFLD-------------TW-EILIRFQIQRNVIVIPGSITPSHIKENIQVFDF 185
Cdd:COG0656  156 YLQQRELlafcREHGIVVeaysPlGRGKLLDdpvlaeiaekhgkTPaQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDF 235

                        250       260
                 ....*....|....*....|...
gi 402478636 186 ELTQHDMDNILSLNRNLRLAMFP 208
Cdd:COG0656  236 ELSDEDMAAIDALDRGERLGPDP 258

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

4-204

2.52e-40

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 139.05 E-value: 2.52e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:PRK11565  15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWNDDHKR--PREA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPM----------------------------GFKPPHPEWIMSCS---------ELsfcls 126
Cdd:PRK11565  89 LEESLKKLQLDYVDLYLMHWPVpaidhyveawkgmielqkegliksigvcNFQIHHLQRLIDETgvtpvinqiEL----- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 HPRVQDLPLDESNMVIPSDTdflDTW----------------------------EILIRFQIQRNVIVIPGSITPSHIKE 178
Cdd:PRK11565 164 HPLMQQRQLHAWNATHKIQT---ESWsplaqggkgvfdqkvirdladkygktpaQIVIRWHLDSGLVVIPKSVTPSRIAE 240

                        250       260
                 ....*....|....*....|....*.
gi 402478636 179 NIQVFDFELTQHDMDNILSLNRNLRL 204
Cdd:PRK11565 241 NFDVFDFRLDKDELGEIAKLDQGKRL 266

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

6-199

3.30e-24

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 97.00 E-value: 3.30e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636    6 AVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYH---NEREVGAGIrckiKEGAVRREDLFIATKL------WCTCHK 76
Cdd:pfam00248   7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgpWPSGGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   77 KSLVETACRKSLKALKLNYLDLYLIHWPmgfKPPHP--EWIMSCSEL-----------SF--------CLSHPR-----V 130
Cdd:pfam00248  83 KENIRKSLEESLKRLGTDYIDLYYLHWP---DPDTPieETWDALEELkkegkiraigvSNfdaeqiekALTKGKipivaV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  131 Q----DLPLDESNMVIP-------------------------SDTDF-------------------------------LD 150
Cdd:pfam00248 160 QveynLLRRRQEEELLEyckkngipliaysplggglltgkytRDPDKgpgerrrllkkgtplnlealealeeiakehgVS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 402478636  151 TWEILIRF--QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 199
Cdd:pfam00248 240 PAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290

Name

Accession

Description

Interval

E-value

AKR_AKR1E1-2

cd19110

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...

1-222

1.98e-144

Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 404.73 E-value: 1.98e-144

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWE------- 153
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEamedlvi 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636     --------------------------------------------------------------------------------
Cdd:cd19110  142 eglvknigvsnfnheqlerllnkpglrvkpvtnqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 154 -----------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 222
Cdd:cd19110  222 iakkhgkspaqILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301

AKR_AKR1B1-19

cd19107

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...

4-222

2.35e-104

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.

Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 303.57 E-value: 2.35e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19107    4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLVKGA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFKPPhpewimscSELsfclshprvqdLPLDESNMVIPSDTDFLDTWE---------- 153
Cdd:cd19107   84 CQKTLSDLKLDYLDLYLIHWPTGFKPG--------KEL-----------FPLDESGNVIPSDTTFLDTWEameelvdegl 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636     --------------------------------------------------------------------------------
Cdd:cd19107  145 vkaigvsnfnhlqierilnkpglkykpavnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledpk 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 154 --------------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFH 219
Cdd:cd19107  225 ikeiaakhnkttaqVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFH 304


                 ...
gi 402478636 220 IEY 222
Cdd:cd19107  305 AEY 307

AKR_AKR1A1-4

cd19106

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...

3-217

1.46e-74

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.

Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 227.65 E-value: 1.46e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19106    6 KMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPGkAVPREDLFVTSKLWNTKHHPEDVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  82 TACRKSLKALKLNYLDLYLIHWPMGFK------PPHPEWIMSCSELSFC-------------------LS---------- 126
Cdd:cd19106   86 PALRKTLKDLQLDYLDLYLIHWPYAFErgdnpfPKNPDGTIRYDSTHYKetwkameklvdkglvkaigLSnfnsrqiddi 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 ---------------HPRVQDLPL----DESNMVI---------------PSDTDFLD--------------TWEILIRF 158
Cdd:cd19106  166 lsvarikpavlqvecHPYLAQNELiahcKARGLVVtaysplgspdrpwakPDEPVLLEepkvkalakkynksPAQILLRW 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402478636 159 QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYP 217
Cdd:cd19106  246 QVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVP 304

AKR_AKR2E1-5

cd19116

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...

4-203

1.80e-66

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.

Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 206.75 E-value: 1.80e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKA-SPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19116   11 IPAIALGTWKLkDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWNSYHEREQVEP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMGFKPPHPE----------------WI-M-SCSELSFCLS------------------ 126
Cdd:cd19116   91 ALRESLKRLGLDYVDLYLIHWPVAFKENNDSesngdgslsdidyletWRgMeDLVKLGLTRSigvsnfnseqinrllsnc 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 -----------HPRVQDLPL----DESNMVI--------------PSDTDFLD--------------TWEILIRFQIQRN 163
Cdd:cd19116  171 nikpavnqievHPTLTQEKLvaycQSNGIVVmayspfgrlvprgqTNPPPRLDdptlvaiakkygktTAQIVLRYLIDRG 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 402478636 164 VIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19116  251 VVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQR 290

AKR_AKR1-5-like

cd19071

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...

4-195

2.41e-66

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.

Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 205.02 E-value: 2.41e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkegaVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19071    1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERVREA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFKPPHP---------------------------------EWIMSCSE---------- 120
Cdd:cd19071   77 LEESLKDLGLDYLDLYLIHWPVPGKEGGSkearletwraleelvdeglvrsigvsnfnvehlEELLAAARikpavnqiel 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 121 ---------LSFCLSH--------P--RVQDLPLDESNMV-I-------PSdtdfldtwEILIRFQIQRNVIVIPGSITP 173
Cdd:cd19071  157 hpylqqkelVEFCKEHgivvqaysPlgRGRRPLLDDPVLKeIakkygktPA--------QVLLRWALQRGVVVIPKSSNP 228

                        250       260
                 ....*....|....*....|..
gi 402478636 174 SHIKENIQVFDFELTQHDMDNI 195
Cdd:cd19071  229 ERIKENLDVFDFELSEEDMAAI 250

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

4-208

6.10e-65

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 201.44 E-value: 6.10e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:COG0656    5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHGYDDTLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMG--------------------------FKPPHPEWIMSCS---------ELsfclsHP 128
Cdd:COG0656   81 FEESLERLGLDYLDLYLIHWPGPgpyvetwraleelyeegliraigvsnFDPEHLEELLAETgvkpavnqvEL-----HP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 129 RVQDLPL----DESNMVI----P-SDTDFLD-------------TW-EILIRFQIQRNVIVIPGSITPSHIKENIQVFDF 185
Cdd:COG0656  156 YLQQRELlafcREHGIVVeaysPlGRGKLLDdpvlaeiaekhgkTPaQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDF 235

                        250       260
                 ....*....|....*....|...
gi 402478636 186 ELTQHDMDNILSLNRNLRLAMFP 208
Cdd:COG0656  236 ELSDEDMAAIDALDRGERLGPDP 258

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

4-203

8.55e-62

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 195.14 E-value: 8.55e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKAS---PGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19108   11 IPVLGFGTYAPEevpKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWCTFHRPELV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHpewimscselsfclshprvQDLPLDESNMVIPSDTDFLDTWE------- 153
Cdd:cd19108   91 RPALEKSLKKLQLDYVDLYLIHFPVALKPGE-------------------ELFPKDENGKLIFDTVDLCATWEamekckd 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636     --------------------------------------------------------------------------------
Cdd:cd19108  152 aglaksigvsnfnrrqlemilnkpglkykpvcnqvechpylnqsklldfckskdivlvaysalgsqrdkewvdqnspvll 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402478636 154 ------------------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19108  232 edpvlcalakkhkrtpalIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299

AKR_AKR3G1

cd19123

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...

4-204

6.76e-60

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.

Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 189.93 E-value: 6.76e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19123   12 IPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWNNSHAPEDVLPA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFKP--PHPE----------------W--IMSCSELSFC-------LSHPRVQDL--- 133
Cdd:cd19123   92 LEKTLADLQLDYLDLYLMHWPVALKKgvGFPEsgedllslspipledtWraMEELVDKGLCrhigvsnFSVKKLEDLlat 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 134 ------------------------------------PL----------DESNMVIPSDTDFLD--------TWEILIRFQ 159
Cdd:cd19123  172 arikpavnqvelhpylqqpellafcrdngihltaysPLgsgdrpaamkAEGEPVLLEDPVINKiaekhgasPAQVLIAWA 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 402478636 160 IQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 204
Cdd:cd19123  252 IQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRY 296

AKR_AKR1D1-3

cd19109

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...

4-218

7.11e-58

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.

Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 185.00 E-value: 7.11e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGL---SSWKASP-GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSL 79
Cdd:cd19109    4 IPIIGLgtySEPKTTPkGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHPPEL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  80 VETACRKSLKALKLNYLDLYLIHWPMGFKP-----PHPE--------------W--IMSCS----------------ELS 122
Cdd:cd19109   84 VRPTLERTLKVLQLDYVDLYIIEMPMAFKPgdeiyPRDEngkwlyhktnlcatWeaLEACKdaglvksigvsnfnrrQLE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 123 FCLSHPRVQDLPL-------------------DESNMVI----PSDTDFLDTW--------------------------E 153
Cdd:cd19109  164 LILNKPGLKHKPVsnqvechpyftqpkllefcQQHDIVIvaysPLGTCRDPIWvnvsspplledpllnsigkkynktaaQ 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 402478636 154 ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPF 218
Cdd:cd19109  244 VVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308

AKR_AKR1G1_CeAKR

cd19154

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...

4-207

6.97e-56

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 179.92 E-value: 6.97e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19154   12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWTHEHAPEDVEEA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIM-------------------------------------SCSELSFCLS 126
Cdd:cd19154   92 LRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTmengmsihdavdvedvwrgmekvydegltkaigvsnfNNDQIQRILD 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 HPRV---------------QDL---------------PL--------DESNMVIPSDTDFLDT-------------WEIL 155
Cdd:cd19154  172 NARVkphnnqvechlyfpqKELvefckkhnisvtsyaTLgspgranfTKSTGVSPAPNLLQDPivkaiaekhgktpAQVL 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 402478636 156 IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 207
Cdd:cd19154  252 LRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRLFLF 303

AKR_AKR4C1-15

cd19125

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...

4-204

1.01e-52

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.

Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 171.37 E-value: 1.01e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19125   11 IPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTDHAPEDVPPA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFK------------------------------------------------------P 109
Cdd:cd19125   91 LEKTLKDLQLDYLDLYLIHWPVRLKkgahmpepeevlppdipstwkameklvdsgkvraigvsnfsvkkledllavarvP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 110 P-------HPEWIMScSELSFC-------------------------LSHPRVQDLP--LDESnmviPSdtdfldtwEIL 155
Cdd:cd19125  171 PavnqvecHPGWQQD-KLHEFCkskgihlsaysplgspgttwvkknvLKDPIVTKVAekLGKT----PA--------QVA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402478636 156 IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 204
Cdd:cd19125  238 LRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRRV 286

AKR_AKR3B1-3

cd19118

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...

4-181

9.45e-48

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.

Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 158.34 E-value: 9.45e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE-GAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19118    7 IPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLWNNSHRPEYVEP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMscselsfclsHPRvqdlPLDESNMVIPSDTDFLDTWEILIRFQIQR 162
Cdd:cd19118   87 ALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPL----------TAV----PTNGGEVDLDLSVSLVDTWKAMVELKKTG 152

                        170       180
                 ....*....|....*....|
gi 402478636 163 NVIVIPGS-ITPSHIKENIQ 181
Cdd:cd19118  153 KVKSIGVSnFSIDHLQAIIE 172

AKR_AKR5C2

cd19131

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...

3-199

1.38e-46

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.

Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 154.45 E-value: 1.38e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19131    9 TIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWNSDQGYDSTLR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPM----------------------------GFKPPHPEWIMSCSELSFCLS----HPRV 130
Cdd:cd19131   85 AFDESLRKLGLDYVDLYLIHWPVpaqdkyvetwkalielkkegrvksigvsNFTIEHLQRLIDETGVVPVVNqielHPRF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 131 QDLPLDE---------------------SNMVIPSDTDFLDT--WEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFEL 187
Cdd:cd19131  165 QQRELRAfhakhgiqteswsplgqggllSDPVIGEIAEKHGKtpAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFEL 244

                        250
                 ....*....|..
gi 402478636 188 TQHDMDNILSLN 199
Cdd:cd19131  245 DADDMQAIAGLD 256

AKR_AKR2A1-2

cd19112

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...

4-203

2.53e-46

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.

Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 155.34 E-value: 2.53e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHkkSLVETA 83
Cdd:cd19112   11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWNSDH--GHVIEA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMG--------------------------------------------------------- 106
Cdd:cd19112   89 CKDSLKKLQLDYLDLYLVHFPVAtkhtgvgttgsalgedgvldidvtislettwhameklvsaglvrsigisnydifltr 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 107 -------FKPP------HPeWIMSCSELSFCLSHPRV--QDLPL-------DESNMVIPSDTDFL---------DTWEIL 155
Cdd:cd19112  169 dclayskIKPAvnqietHP-YFQRDSLVKFCQKHGISvtAHTPLggaaanaEWFGSVSPLDDPVLkdlakkygkSAAQIV 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 402478636 156 IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19112  248 LRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYR 295

AKR_AKR5F1

cd19133

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...

4-199

5.46e-46

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 153.11 E-value: 5.46e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTC-----HKK 77
Cdd:cd19133    9 MPILGFGVFQIPDPEECErAVLEAIKAGYRLIDTAAAYGNEEAVGRA----IKKSGIPREELFITTKLWIQDagyekAKK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  78 SLvetacRKSLKALKLNYLDLYLIHWPMG-------------------------FKP-------PHPEWIMSCSELSFCL 125
Cdd:cd19133   85 AF-----ERSLKRLGLDYLDLYLIHQPFGdvygawrameelykegkiraigvsnFYPdrlvdliLHNEVKPAVNQIETHP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 126 SHPRVQDLPLDESNMVIPS--------DTDFLD--------------TWEILIRFQIQRNVIVIPGSITPSHIKENIQVF 183
Cdd:cd19133  160 FNQQIEAVEFLKKYGVQIEawgpfaegRNNLFEnpvlteiaekygksVAQVILRWLIQRGIVVIPKSVRPERIAENFDIF 239

                        250
                 ....*....|....*.
gi 402478636 184 DFELTQHDMDNILSLN 199
Cdd:cd19133  240 DFELSDEDMEAIAALD 255

AKR_AKR5A_5G

cd19126

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...

4-199

1.65e-45

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 151.82 E-value: 1.65e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19126    9 MPWLGLGVFQTPDGDETErAVQTALENGYRSIDTAAIYKNEEGVGEAIR----ESGVPREELFVTTKLWNDDQRARRTED 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPM--------------------------GFKPPHPEWIMSCSELS-------------- 122
Cdd:cd19126   85 AFQESLDRLGLDYVDLYLIHWPGkdkfidtwkaleklyasgkvkaigvsNFQEHHLEELLAHADVVpavnqvefhpyltq 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 123 -----FCLSH--------PRVQDLPLDESNMVIPSDTDFLDTWEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQ 189
Cdd:cd19126  165 kelrgYCKSKgivveawsPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSE 244

                        250
                 ....*....|
gi 402478636 190 HDMDNILSLN 199
Cdd:cd19126  245 DDMTAIDALN 254

AKR_AKR5G1-3

cd19157

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...

4-203

5.42e-45

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 150.62 E-value: 5.42e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGK-VTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19157   10 MPWLGLGVFKVEEGSeVVNAVKTALKNGYRSIDTAAIYGNEEGVGKG----IKESGIPREELFITSKVWNADQGYDSTLK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMG--------------------------FKPPHPEWIMSCSEL--------------- 121
Cdd:cd19157   86 AFEASLERLGLDYLDLYLIHWPVKgkyketwkaleklykdgrvraigvsnFQVHHLEDLLADAEIvpmvnqvefhprltq 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 122 ----SFCLSH--------PRVQDLPLDESNMVIPSDTDFLDTWEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQ 189
Cdd:cd19157  166 kelrDYCKKQgiqleawsPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQ 245

                        250
                 ....*....|....
gi 402478636 190 HDMDNILSLNRNLR 203
Cdd:cd19157  246 EDMDKIDALNENLR 259

AKR_AKR1G1_1I

cd19111

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...

4-207

1.37e-44

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 150.34 E-value: 1.37e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19111    4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEFKDTEKS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFK-----------------------------------------------------PP 110
Cdd:cd19111   84 LEKSLENLKLPYVDLYLIHHPCGFVnkkdkgerelassdvtsvwramealvsegkvksiglsnfnprqinkilayakvKP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 111 HP------------EWIMSCSELSFCL--------------SHPRVQDLPLDESNMV-IPSDTDFLDTwEILIRFQIQRN 163
Cdd:cd19111  164 SNlqlechaylqqrELRKFCNKKNIVVtayaplgspgranqSLWPDQPDLLEDPTVLaIAKELDKTPA-QVLLRFVLQRG 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 402478636 164 VIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 207
Cdd:cd19111  243 TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKYFDF 286

AKR_AKR3F2_3

cd19073

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...

4-195

1.45e-43

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 146.26 E-value: 1.45e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19073    1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDLKKS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWP------------------------MG---FKPPHPEWIMSCSELS-------------- 122
Cdd:cd19073   77 VDRSLEKLGTDYVDLLLIHWPnptvpleetlgalkelkeagkvksIGvsnFTIELLEEALDISPLPiavnqvefhpflyq 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 123 -----FC------------------LSHPRVQDLPldESNMVIPSdtdfldtwEILIRFQIQRNVIVIPGSITPSHIKEN 179
Cdd:cd19073  157 aelleYCrendivitaysplargevLRDPVIQEIA--EKYDKTPA--------QVALRWLVQKGIVVIPKASSEDHLKEN 226

                        250
                 ....*....|....*.
gi 402478636 180 IQVFDFELTQHDMDNI 195
Cdd:cd19073  227 LAIFDWELTSEDVAKI 242

AKR_AKR3D1

cd19121

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...

4-198

2.89e-43

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.

Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 146.91 E-value: 2.89e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:cd19121   12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWSTYHRR--VELC 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPM-----GFKPPHP-----------EW----------------------IMSCS------ 119
Cdd:cd19121   89 LDRSLKSLGLDYVDLYLVHWPVllnpnGNHDLFPtlpdgsrdldwDWnhvdtwkqmekvlktgktkaigVSNYSipylee 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 120 -----------------------ELS-FCLS---HPRVQDlPLDESNMVIPSDTDFLDTWE--------ILIRFQIQRNV 164
Cdd:cd19121  169 llkhatvvpavnqvenhpylpqqELVdFCKEkgiLIEAYS-PLGSTGSPLISDEPVVEIAKkhnvgpgtVLISYQVARGA 247

                        250       260       270
                 ....*....|....*....|....*....|....
gi 402478636 165 IVIPGSITPSHIKENIQVFDFelTQHDMDNILSL 198
Cdd:cd19121  248 VVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279

AKR_AKR2B1-10

cd19113

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...

3-203

5.19e-42

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.

Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 144.13 E-value: 5.19e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19113   10 KMPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFHDPKNVET 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMGFK--------PP-------------------------------------------- 110
Cdd:cd19113   90 ALNKTLSDLKLDYVDLFLIHFPIAFKfvpieekyPPgfycgdgdnfvyedvpildtwkaleklvdagkiksigvsnfpga 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 111 --------------------HP--------EWIM----------SCSELSFC-LSHPRVQDLPLDESNMVIPSDTDFLD- 150
Cdd:cd19113  170 lildllrgatikpavlqiehHPylqqpkliEYAQkagititaysSFGPQSFVeLNQGRALNTPTLFEHDTIKSIAAKHNk 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402478636 151 -TWEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19113  250 tPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLR 303

AKR_AKR1I_CgAKR1

cd19155

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...

4-207

1.39e-41

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 143.05 E-value: 1.39e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19155   12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPPGGNRREKVEKF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGF-------------------------------------------------------- 107
Cdd:cd19155   92 LLKSLEKLQLDYVDLYLIHFPVGSlskeddsgkldptgehkqdyttdlldiwkameaqvdqgltrsiglsnfnreqmari 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 108 ------KPP-----HPEWIMSCSELSFCLSH-------------------PRVQDLPLDESN-MVIPSDTDFLDTW---- 152
Cdd:cd19155  172 lknariKPAnlqveLHVYLQQKDLVDFCSTHsitvtayaplgspgaahfsPGTGSPSGSSPDlLQDPVVKAIAERHgksp 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 402478636 153 -EILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 207
Cdd:cd19155  252 aQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRGRTF 307

AKR_AKR5A1_2

cd19156

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...

4-208

2.12e-41

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 141.50 E-value: 2.12e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19156    9 MPRLGLGVWRVQDGAEAEnAVKWAIEAGYRHIDTAAIYKNEEGVGQGIR----ESGVPREEVFVTTKLWNSDQGYESTLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMG--------------------------FKPPHPEWIMSCSELSFCLS----HPRVQD 132
Cdd:cd19156   85 AFEESLEKLGLDYVDLYLIHWPVKgkfkdtwkafeklykekkvraigvsnFHEHHLEELLKSCKVAPMVNqielHPLLTQ 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 133 LPL----DESNMVIpsdtdflDTW--------------------------EILIRFQIQRNVIVIPGSITPSHIKENIQV 182
Cdd:cd19156  165 EPLrkfcKEKNIAV-------EAWsplgqgkllsnpvlkaigkkygksaaQVIIRWDIQHGIITIPKSVHEERIQENFDV 237

                        250       260
                 ....*....|....*....|....*.
gi 402478636 183 FDFELTQHDMDNILSLNRNLRLAMFP 208
Cdd:cd19156  238 FDFELTAEEIRQIDGLNTDHRYGPDP 263

AKR_DrGR-like

cd19136

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...

4-198

9.93e-41

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).

Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 139.69 E-value: 9.93e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19136    1 MPILGLGTFRLRGEEEVRqAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEKARA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWP--MGFKPPHPE--------W---------------------------IMSCSE----- 120
Cdd:cd19136   81 ACLGSLERLGTDYLDLYLIHWPgvQGLKPSDPRnaelrresWraledlykegklraigvsnytvrhleeLLKYCEvppav 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 121 --------------LSFCLSHP-RVQDL-PLDESNMVIPSDTDFLDTWE--------ILIRFQIQRNVIVIPGSITPSHI 176
Cdd:cd19136  161 nqvefhphlvqkelLKFCKDHGiHLQAYsSLGSGDLRLLEDPTVLAIAKkygrtpaqVLLRWALQQGIGVIPKSTNPERI 240

                        250       260
                 ....*....|....*....|..
gi 402478636 177 KENIQVFDFELTQHDMDNILSL 198
Cdd:cd19136  241 AENIKVFDFELSEEDMAELNAL 262

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

4-204

2.52e-40

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 139.05 E-value: 2.52e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:PRK11565  15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWNDDHKR--PREA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPM----------------------------GFKPPHPEWIMSCS---------ELsfcls 126
Cdd:PRK11565  89 LEESLKKLQLDYVDLYLMHWPVpaidhyveawkgmielqkegliksigvcNFQIHHLQRLIDETgvtpvinqiEL----- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 HPRVQDLPLDESNMVIPSDTdflDTW----------------------------EILIRFQIQRNVIVIPGSITPSHIKE 178
Cdd:PRK11565 164 HPLMQQRQLHAWNATHKIQT---ESWsplaqggkgvfdqkvirdladkygktpaQIVIRWHLDSGLVVIPKSVTPSRIAE 240

                        250       260
                 ....*....|....*....|....*.
gi 402478636 179 NIQVFDFELTQHDMDNILSLNRNLRL 204
Cdd:PRK11565 241 NFDVFDFRLDKDELGEIAKLDQGKRL 266

AKR_AKR3F3

cd19140

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...

3-198

2.71e-40

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 138.16 E-value: 2.71e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19140    7 RIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDELFLTTKVWPDNYSPDDFLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWP------------------MG---------FKPPHPEWIMSCSELSF----CLSHPRVQ 131
Cdd:cd19140   83 SVEESLRKLRTDYVDLLLLHWPnkdvplaetlgalneaqeAGlarhigvsnFTVALLREAVELSEAPLftnqVEYHPYLD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 132 DLPL----DESNMV-----------IPSDTDFLDTWE--------ILIRFQIQR-NVIVIPGSITPSHIKENIQVFDFEL 187
Cdd:cd19140  163 QRKLldaaREHGIAltaysplargeVLKDPVLQEIGRkhgktpaqVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTL 242

                        250
                 ....*....|.
gi 402478636 188 TQHDMDNILSL 198
Cdd:cd19140  243 SDEEMARIAAL 253

AKR_AKR3A1-2

cd19117

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...

4-200

3.48e-40

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.

Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 138.79 E-value: 3.48e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:cd19117   14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQG----IKDSGVPREEIFITTKLWCTWHRR--VEEA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMGFKPPH---------------PEW--IMSCSELSFCLSHPRV-------------QDL 133
Cdd:cd19117   88 LDQSLKKLGLDYVDLYLMHWPVPLDPDGndflfkkddgtkdhePDWdfIKTWELMQKLPATGKVkaigvsnfsiknlEKL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 134 PLDESNMVIP-----------------------------------SDTDFL--------------DTWEILIRFQIQRNV 164
Cdd:cd19117  168 LASPSAKIVPavnqielhpllpqpklvdfckskgihataysplgsTNAPLLkepviikiakkhgkTPAQVIISWGLQRGY 247

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 402478636 165 IVIPGSITPSHIKENIQVfdFELTQHDMDNILSLNR 200
Cdd:cd19117  248 SVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281

AKR_GlAR-like

cd19128

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...

5-198

5.47e-40

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 138.04 E-value: 5.47e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   5 PAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETAC 84
Cdd:cd19128    2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVKEQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  85 RKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHP-----RVQDLPLDE--------SNMVIPSDTDFLDT 151
Cdd:cd19128   82 LITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPledtwRAMEQCVDEkltknigvSNYSTKLLTDLLNY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 152 WEI-----------------LIRFQIQRNVIV------------------------------------------------ 166
Cdd:cd19128  162 CKIkpfmnqiechpyfqndkLIKFCIENNIHVtayrplggsygdgnltflndselkalatkynttppqviiawhlqkwpk 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 402478636 167 ----IPGSITPSHIKENIQVFDFELTQHDMDNILSL 198
Cdd:cd19128  242 nysvIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277

AKR_BaDH-like

cd19129

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...

2-155

1.07e-39

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.

Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 137.97 E-value: 1.07e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19129    4 GAIPALGFGTLIPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNHRPERVK 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 402478636  82 TACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvQDlPLDESNMVIPSD-TDFLDTWEIL 155
Cdd:cd19129   84 PAFEASLKRLQLDYLDLYLIHTPFAFQPGDE------------------QD-PRDANGNVIYDDgVTLLDTWRAM 139

AKR_AKR2D1

cd19115

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...

2-203

1.60e-38

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.

Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 135.24 E-value: 1.60e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19115   11 YDMPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWNTFHDGERVE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  82 TACRKSLKALKLNYLDLYLIHWPMGFK--------PP------------------------------------------- 110
Cdd:cd19115   91 PICRKQLADWGIDYFDLFLIHFPIALKyvdpavryPPgwfydgkkvefsnapiqetwtameklvdkglarsigvsnfsaq 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 111 --------------------HP-------------EWIM-----SCSELSFC-LSHPRVQDL-PLDESNMVIPSDTDFLD 150
Cdd:cd19115  171 llmdllryarirpatlqiehHPyltqprlvkyaqkEGIAvtaysSFGPQSFLeLDLPGAKDTpPLFEHDVIKSIAEKHGK 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402478636 151 T-WEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19115  251 TpAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLR 304

AKR_AKR2C1

cd19114

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...

2-203

7.10e-36

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.

Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 128.06 E-value: 7.10e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   2 GD-IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19114    1 GDkMPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGKDHV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFK-------------------------PPHPEWI-------------------- 115
Cdd:cd19114   81 REAFDRQLKDYGLDYIDLYLIHFPIPAAyvdpaenypflwkdkelkkfpleqsPMQECWRemeklvdaglvrnigianfn 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 116 --MSCSELSFCLSHPRV--------------------QDL------------------------PLDESNMVIP-SDTDF 148
Cdd:cd19114  161 vqLILDLLTYAKIKPAVlqiehhpylqqkrlidwakkQGIqitayssfgnavytkvtkhlkhftNLLEHPVVKKlADKHK 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402478636 149 LDTWEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 203
Cdd:cd19114  241 RDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANAR 295

AKR_CeZK1290-like

cd19135

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...

4-192

2.66e-35

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 125.51 E-value: 2.66e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKaSPGKVTEAVKEAI-DAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19135   13 MPILGLGTSH-SGGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAI----KESGVPREDLFLTTKLWPSDYGYESTKQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPMG----------------------------------FKPPHPEWIMSCSE-------- 120
Cdd:cd19135   88 AFEASLKRLGVDYLDLYLLHWPDCpssgknvketraetwraleelydeglcraigvsnFLIEHLEQLLEDCSvvphvnqv 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 121 -----------LSFC------------------LSHPRVQDLPldESNMVIPSdtdfldtwEILIRFQIQRNVIVIPGSI 171
Cdd:cd19135  168 efhpfqnpvelIEYCrdnnivfegycplakgkaLEEPTVTELA--KKYQKTPA--------QILIRWSIQNGVVTIPKST 237

                        250       260
                 ....*....|....*....|.
gi 402478636 172 TPSHIKENIQVFDFELTQHDM 192
Cdd:cd19135  238 KEERIKENCQVFDFSLSEEDM 258

AKR_AKR4A_4B

cd19124

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...

4-195

2.70e-35

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.

Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 126.23 E-value: 2.70e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGL--SSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR-REDLFIATKLWCTCHKKSLV 80
Cdd:cd19124    5 MPVIGMgtASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDAHPDLV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPMGFK------PPHPEWIM----------------------------SCSELSFCLS 126
Cdd:cd19124   85 LPALKKSLRNLQLEYVDLYLIHWPVSLKpgkfsfPIEEEDFLpfdikgvweameecqrlgltkaigvsnfSCKKLQELLS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 127 -------------HPRVQDLPLDE-----------------------SNMVIPSDTdFLD--------TWEILIRFQIQR 162
Cdd:cd19124  165 fatippavnqvemNPAWQQKKLREfckangihvtaysplgapgtkwgSNAVMESDV-LKEiaaakgktVAQVSLRWVYEQ 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 402478636 163 NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 195
Cdd:cd19124  244 GVSLVVKSFNKERMKQNLDIFDWELTEEDLEKI 276

AKR_AKR5H1

cd19134

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...

4-204

7.48e-35

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.

Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 124.58 E-value: 7.48e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19134   11 MPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIA----ASGIPRGELFVTTKLATPDQGFTASQAA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPMG----------------------------FKPPHPEWIMSCSELSFCLS----HPRVQ 131
Cdd:cd19134   87 CRASLERLGLDYVDLYLIHWPAGregkyvdswgglmklreeglarsigvsnFTAEHLENLIDLTFFTPAVNqielHPLLN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 132 DLPLDESN------------------MVIPSDTDFLDTW-----EILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELT 188
Cdd:cd19134  167 QAELRKVNaqhgivtqaysplgvgrlLDNPAVTAIAAAHgrtpaQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELT 246

                        250
                 ....*....|....*.
gi 402478636 189 QHDMDNILSLNRNLRL 204
Cdd:cd19134  247 ADHMDALDGLDDGTRF 262

AKR_AKR5D1_E1

cd19132

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...

2-200

1.84e-34

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 123.15 E-value: 1.84e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19132    5 TQIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVR----RSGVPREELFVTTKLPGRHHGYEEAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  82 TACRKSLKALKLNYLDLYLIHWP-------------------------MG---FKPPHPEWIMSCS---------ELsfc 124
Cdd:cd19132   81 RTIEESLYRLGLDYVDLYLIHWPnpsrdlyveawqalieareeglvrsIGvsnFLPEHLDRLIDETgvtpavnqiEL--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 125 lsHPRVQDLPL----DESNMVIPS------DTDFLD--------------TWEILIRFQIQRNVIVIPGSITPSHIKENI 180
Cdd:cd19132  158 --HPYFPQAEQrayhREHGIVTQSwsplgrGSGLLDepvikaiaekhgktPAQVVLRWHVQLGVVPIPKSANPERQRENL 235

                        250       260
                 ....*....|....*....|
gi 402478636 181 QVFDFELTQHDMDNILSLNR 200
Cdd:cd19132  236 AIFDFELSDEDMAAIAALDR 255

AKR_AKR5B1

cd19127

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...

3-199

2.11e-34

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.

Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 123.29 E-value: 2.11e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19127    8 EMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIR----RSGVDRSDIFVTTKLWISDYGYDKALR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  83 ACRKSLKALKLNYLDLYLIHWPM-----------------------------GFKPPHPEWIMSCS---------ELSFC 124
Cdd:cd19127   84 GFDASLRRLGLDYVDLYLLHWPVpndfdrtiqaykalekllaegrvraigvsNFTPEHLERLIDATtvvpavnqvELHPY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 125 LSHPRVQDL------------------------------PLDESNMVIPSDTDFLDTWEILIRFQIQRNVIVIPGSITPS 174
Cdd:cd19127  164 FSQKDLRAFhrrlgivtqawspiggvmrygasgptgpgdVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPE 243

                        250       260
                 ....*....|....*....|....*
gi 402478636 175 HIKENIQVFDFELTQHDMDNILSLN 199
Cdd:cd19127  244 RIAENIDIFDFALSAEDMAAIDALD 268

AKR_AKR3C2-3

cd19120

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...

4-195

2.14e-32

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.

Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 118.10 E-value: 2.14e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGL---SSWKASPG-----KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCtch 75
Cdd:cd19120    4 IPAIAFgtgTAWYKSGDddiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEA----LKESGVPREDLFITTKVSP--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  76 KKSLVETACRKSLKALKLNYLDLYLIHWP----------------------MG---------FKPPHPEWIMSCS----- 119
Cdd:cd19120   77 GIKDPREALRKSLAKLGVDYVDLYLIHSPffakeggptlaeawaelealkdAGlvrsigvsnFRIEDLEELLDTAkikpa 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 120 ----ELSFCLSHPRVQDLPLDESNMVIPS------------DTDFLDTWE------------ILIRFQIQRNVIVIPGSI 171
Cdd:cd19120  157 vnqiEFHPYLYPQQPALLEYCREHGIVVSaysplspltrdaGGPLDPVLEkiaekygvtpaqVLLRWALQKGIVVVTTSS 236

                        250       260
                 ....*....|....*....|....
gi 402478636 172 TPSHIKENIQVFDFELTQHDMDNI 195
Cdd:cd19120  237 KEERMKEYLEAFDFELTEEEVEEI 260

AKR_AKR5C1

cd19130

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...

4-199

6.39e-32

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.

Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 116.55 E-value: 6.39e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKikegAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19130   10 IPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAAS----GIPRDELFVTTKLWNDRHDGDEPAAA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  84 CRKSLKALKLNYLDLYLIHWPM----------------------------GFKPPHPEWIMSCSELSFCLS----HPRVQ 131
Cdd:cd19130   86 FAESLAKLGLDQVDLYLVHWPTpaagnyvhtweamielraagrtrsigvsNFLPPHLERIVAATGVVPAVNqielHPAYQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 132 DLPLDES----NMVIPS------DTDFLD-------------TWEILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELT 188
Cdd:cd19130  166 QRTIRDWaqahDVKIEAwsplgqGKLLGDppvgaiaaahgktPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLT 245

                        250
                 ....*....|.
gi 402478636 189 QHDMDNILSLN 199
Cdd:cd19130  246 DTEIAAIDALD 256

AKR_AKR3C1

cd19119

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...

4-108

1.06e-31

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).

Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 117.21 E-value: 1.06e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWkaSP----GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKsl 79
Cdd:cd19119   12 IPALGLGTA--SPhedrAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPTFYDE-- 87

                         90       100
                 ....*....|....*....|....*....
gi 402478636  80 VETACRKSLKALKLNYLDLYLIHWPMGFK 108
Cdd:cd19119   88 VERSLDESLKALGLDYVDLLLVHWPVCFE 116

AKR_AKR3E1

cd19122

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...

4-105

4.60e-31

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.

Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 115.41 E-value: 4.60e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSW--KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19122    9 IPAVGFGTFanEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWNHLHEPEDV 88

                         90       100
                 ....*....|....*....|....*
gi 402478636  81 ETACRKSLKALKLNYLDLYLIHWPM 105
Cdd:cd19122   89 KWSIDNSLKNLKLDYIDLFLVHWPI 113

AKR_AKR3F1-like

cd19072

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...

4-195

1.72e-27

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 105.00 E-value: 1.72e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLW 71
Cdd:cd19072    4 VPVLGLGTWGigggmskdySDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITTKVS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  72 CTCHKKSLVETACRKSLKALKLNYLDLYLIHWP------------MG---------------FKPPHPEWIMSCS----- 119
Cdd:cd19072   78 PDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPnpsipieetlraMEelveegkiryigvsnFSLEELEEAQSYLkkgpi 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 120 ---ELSFCLSHPRVQD----------------LPLDESNMVIPSDTDFLD---------TWEILIRFQIQR-NVIVIPGS 170
Cdd:cd19072  158 vanQVEYNLFDREEESgllpycqkngiaiiaySPLEKGKLSNAKGSPLLDeiakkygktPAQIALNWLISKpNVIAIPKA 237

                        250       260
                 ....*....|....*....|....*
gi 402478636 171 ITPSHIKENIQVFDFELTQHDMDNI 195
Cdd:cd19072  238 SNIEHLEENAGALGWELSEEDLQRL 262

AKR_AKR3F2

cd19139

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...

4-104

2.61e-26

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 101.66 E-value: 2.61e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19139    1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLSKDKLLPS 76

                         90       100
                 ....*....|....*....|.
gi 402478636  84 CRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19139   77 LEESLEKLRTDYVDLTLIHWP 97

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

6-199

3.30e-24

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 97.00 E-value: 3.30e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636    6 AVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYH---NEREVGAGIrckiKEGAVRREDLFIATKL------WCTCHK 76
Cdd:pfam00248   7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgpWPSGGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   77 KSLVETACRKSLKALKLNYLDLYLIHWPmgfKPPHP--EWIMSCSEL-----------SF--------CLSHPR-----V 130
Cdd:pfam00248  83 KENIRKSLEESLKRLGTDYIDLYYLHWP---DPDTPieETWDALEELkkegkiraigvSNfdaeqiekALTKGKipivaV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  131 Q----DLPLDESNMVIP-------------------------SDTDF-------------------------------LD 150
Cdd:pfam00248 160 QveynLLRRRQEEELLEyckkngipliaysplggglltgkytRDPDKgpgerrrllkkgtplnlealealeeiakehgVS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 402478636  151 TWEILIRF--QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 199
Cdd:pfam00248 240 PAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290

dkgB

PRK11172

2,5-didehydrogluconate reductase DkgB;

4-104

2.92e-22

2,5-didehydrogluconate reductase DkgB;

Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 91.24 E-value: 2.92e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:PRK11172   3 IPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLAKDKLIPS 78

                         90       100
                 ....*....|....*....|.
gi 402478636  84 CRKSLKALKLNYLDLYLIHWP 104
Cdd:PRK11172  79 LKESLQKLRTDYVDLTLIHWP 99

AKR_AKR11B3

cd19085

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...

4-112

9.07e-22

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.

Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 90.72 E-value: 9.07e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTE---------AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGavRREDLFIATKLW 71
Cdd:cd19085    1 VSRLGLGCWQFGGGYWWGdqddeesiaTIHAALDAGINFFDTAEAYgdgHSEEVLGKAL-----KG--RRDDVVIATKVS 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 402478636  72 cTCH-KKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHP 112
Cdd:cd19085   74 -PDNlTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEE 114

AKR_AKR3F1

cd19137

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...

4-193

3.93e-18

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 80.31 E-value: 3.93e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLW 71
Cdd:cd19137    4 IPALGLGTWGiggfltpdySRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIK------DFPREDLFIVTKVW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  72 CTCHKKSLVETACRKSLKALKLNYLDLYLIHWPmgfKPPHP-EWIMS--------------------------------- 117
Cdd:cd19137   78 PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP---NPNIPlEETLSamaegvrqgliryigvsnfnrrlleeaisksqt 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636 118 ---CSELSFCLSHPRVQD---LPLDESNMVI-----PSDTDFLDTWEILIR---------FQI-------QRNVIVIPGS 170
Cdd:cd19137  155 pivCNQVKYNLEDRDPERdglLEYCQKNGITvvaysPLRRGLEKTNRTLEEiaknygktiAQIalawliqKPNVVAIPKA 234

                        250       260
                 ....*....|....*....|...
gi 402478636 171 ITPSHIKENIQVFDFELTQHDMD 193
Cdd:cd19137  235 GRVEHLKENLKATEIKLSEEEMK 257

AKR_YeaE

cd19138

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...

4-104

7.05e-18

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 79.60 E-value: 7.05e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRCkikegavRREDLFIATKLWCTCH 75
Cdd:cd19138   11 VPALGQGTWymgedPAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRG-------RRDKVFLVSKVLPSNA 83

                         90       100
                 ....*....|....*....|....*....
gi 402478636  76 KKSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19138   84 SRQGTVRACERSLRRLGTDYLDLYLLHWR 112

PdxI

COG0667

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...

8-104

4.20e-16

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];

Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 75.21 E-value: 4.20e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKL--------WCTCHK 76
Cdd:COG0667   24 GGPWGGVDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK------GRPRDDVVIATKVgrrmgpgpNGRGLS 97

                         90       100
                 ....*....|....*....|....*...
gi 402478636  77 KSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:COG0667   98 REHIRRAVEASLRRLGTDYIDLYQLHRP 125

AKR_SF

cd06660

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...

21-104

1.61e-15

Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 72.55 E-value: 1.61e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  21 EAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikeGAVRREDLFIATKLWCT---------CHKKSLVEtACRKSL 88
Cdd:cd06660   21 ALLDAALEAGGNFFDTADVYgdgRSERLLGRWLK-----GRGNRDDVVIATKGGHPpggdpsrsrLSPEHIRR-DLEESL 94

                         90
                 ....*....|....*.
gi 402478636  89 KALKLNYLDLYLIHWP 104
Cdd:cd06660   95 RRLGTDYIDLYYLHRD 110

AKR_unchar

cd19105

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

14-102

3.34e-15

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 71.85 E-value: 3.34e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  14 ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLWCTCHKKS---LVETAcRKS 87
Cdd:cd19105   22 GLPRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRLDKKDkaeLLKSV-EES 94

                         90
                 ....*....|....*
gi 402478636  88 LKALKLNYLDLYLIH 102
Cdd:cd19105   95 LKRLQTDYIDIYQLH 109

AKR_AtPLR-like

cd19093

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...

4-115

6.64e-15

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.

Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 71.88 E-value: 6.64e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKA-----------SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckiKEGAVRrEDLFIATK 69
Cdd:cd19093    2 VSPLGLGTWQWgdrlwwgygeyGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFL----KELGDR-DEVVIATK 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 402478636  70 LWCTCHKKSL--VETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWI 115
Cdd:cd19093   77 FAPLPWRLTRrsVVKALKASLERLGLDSIDLYQLHWPGPWYSQIEALM 124

AKR_AKR11B1-like

cd19084

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...

4-104

2.99e-14

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 69.86 E-value: 2.99e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASP---GKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATK--- 69
Cdd:cd19084    4 VSRIGLGTWAIGGtwwGEVDDqesieAIKAAIDLGINFFDTAPVYgfgHSEEILGKAL-------KGRRDDVVIATKcgl 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 402478636  70 LW------CTCHKKSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19084   77 RWdggkgvTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWP 117

AKR_AKR11C1

cd19086

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...

4-105

3.82e-14

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.

Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 69.04 E-value: 3.82e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSW--------KASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGagircKIKEGavRREDLFIATKLWC 72
Cdd:cd19086    3 VSEIGFGTWglggdwwgDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLG-----KALKG--RRDKVVIATKFGN 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 402478636  73 TCHK---------KSLVETACRKSLKALKLNYLDLYLIH-WPM 105
Cdd:cd19086   76 RFDGgperpqdfsPEYIREAVEASLKRLGTDYIDLYQLHnPPD 118

COG1453

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

18-102

5.78e-14

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 69.85 E-value: 5.78e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  18 KVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRCkikegavRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYL 96
Cdd:COG1453   30 EAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-------PRDKVILATKLPPWVRDPEDMRKDLEESLKRLQTDYI 102


                 ....*.
gi 402478636  97 DLYLIH 102
Cdd:COG1453  103 DLYLIH 108

AKR_PA4992-like

cd19095

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...

5-102

1.43e-13

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 67.65 E-value: 1.43e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   5 PAVGLSSWK--ASPGKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATKLWCTC-- 74
Cdd:cd19095    1 SVLGLGTSGigRVWGVPSEAeaarlLNTALDLGINLIDTAPAYGRsEERLGRALA------GLRRDDLFIATKVGTHGeg 74

                         90       100       110
                 ....*....|....*....|....*....|....
gi 402478636  75 ------HKKSLVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19095   75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLH 108

AKR_unchar

cd19100

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

8-102

4.22e-12

Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 63.27 E-value: 4.22e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikeGavRREDLFIATKlwcTCHKKSlvETACR- 85
Cdd:cd19100   18 GGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALK-----G--RRDKVFLATK---TGARDY--EGAKRd 85

                         90
                 ....*....|....*....
gi 402478636  86 --KSLKALKLNYLDLYLIH 102
Cdd:cd19100   86 leRSLKRLGTDYIDLYQLH 104

AKR_Fe-S_oxidoreductase

cd19096

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...

13-117

8.16e-12

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 62.58 E-value: 8.16e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  13 KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL-WCTCHKKSLVETACRKSL 88
Cdd:cd19096   17 SIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALK------EGPREKFYLATKLpPWSVKSAEDFRRILEESL 90

                         90       100
                 ....*....|....*....|....*....
gi 402478636  89 KALKLNYLDLYLIHWPMgfKPPHPEWIMS 117
Cdd:cd19096   91 KRLGVDYIDFYLLHGLN--SPEWLEKARK 117

Aldo_ket_red_shaker-like

cd19074

Shaker potassium channel beta subunit family and similar proteins; This family includes ...

7-102

1.34e-11

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 62.61 E-value: 1.34e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   7 VGLSSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL-WCT---- 73
Cdd:cd19074    7 LSLGTWLTFGGQVDdedakACVRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKVfWPTgpgp 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 402478636  74 ----CHKKSLVEtACRKSLKALKLNYLDLYLIH 102
Cdd:cd19074   81 ndrgLSRKHIFE-SIHASLKRLQLDYVDIYYCH 112

AKR_unchar

cd19102

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

6-104

2.85e-11

Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 61.53 E-value: 2.85e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   6 AVGLSSWKASPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK---LW--- 71
Cdd:cd19102   10 AIGGGGWGGGWGPQDDrdsiaAIRAALDLGINWIDTAAVYglgHSEEVVGRALK-------GLRDRPIVATKcglLWdee 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 402478636  72 ---CTCHKKSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19102   83 griRRSLKPASIRAECEASLRRLGVDVIDLYQIHWP 118

AKR_AKR11A1_11D1

cd19083

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...

23-109

6.43e-10

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).

Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 57.81 E-value: 6.43e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKlwcTCHKKS-----------LVETACRKSL 88
Cdd:cd19083   39 VREALDNGVNLLDTAFIYglgRSEELVGEVLK------EYNRNEVVIATK---GAHKFGgdgsvlnnspeFLRSAVEKSL 109

                         90       100
                 ....*....|....*....|.
gi 402478636  89 KALKLNYLDLYLIHWPMGFKP 109
Cdd:cd19083  110 KRLNTDYIDLYYIHFPDGETP 130

AKR_EcYajO-like

cd19079

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...

12-103

3.23e-09

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 55.67 E-value: 3.23e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  12 WKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikeGAVRREDLFIATKLwctCHKKSL--------- 79
Cdd:cd19079   30 WVLDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALK-----EFAPRDEVVIATKV---YFPMGDgpngrglsr 101

                         90       100
                 ....*....|....*....|....*.
gi 402478636  80 --VETACRKSLKALKLNYLDLYLIHW 103
Cdd:cd19079  102 khIMAEVDASLKRLGTDYIDLYQIHR 127

AKR_unchar

cd19099

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

21-104

3.83e-09

Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 55.40 E-value: 3.83e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  21 EAVKEAIDAGYRHFDCA--YFY-HNEREVGAGIRCKIKEGAVRREDLFIATK---------------------------- 69
Cdd:cd19099   25 EALKAALDSGINVIDTAinYRGgRSERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgdeplrplkyleeklgrglid 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 402478636  70 ------LWCTCHKKSLVEtACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19099  105 vadsagLRHCISPAYLED-QIERSLKRLGLDTIDLYLLHNP 144

AKR_BsYcsN_EcYdhF-like

cd19092

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...

8-104

7.61e-09

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.

Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 54.48 E-value: 7.61e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIrckiKEGAVRREDLFIATK----------LWCTC 74
Cdd:cd19092   15 RLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEAL----ALNPGLREKIEIQTKcgirlgddprPGRIK 90

                         90       100       110
                 ....*....|....*....|....*....|...
gi 402478636  75 H---KKSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19092   91 HydtSKEHILASVEGSLKRLGTDYLDLLLLHRP 123

AKR_AKR6C1_2

cd19143

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...

19-104

9.02e-09

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 54.52 E-value: 9.02e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  19 VTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIrckiKEGAVRREDLFIATKL-W---------CTCHKKSLVEtACR 85
Cdd:cd19143   33 AKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAI----KELGWPRSDYVVSTKIfWggggpppndRGLSRKHIVE-GTK 107

                         90
                 ....*....|....*....
gi 402478636  86 KSLKALKLNYLDLYLIHWP 104
Cdd:cd19143  108 ASLKRLQLDYVDLVFCHRP 126

AKR_AKR15A-like

cd19090

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...

5-114

1.91e-08

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 53.33 E-value: 1.91e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   5 PAVGL--SSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATKLwCTCHK 76
Cdd:cd19090    1 SALGLgtAGLGGVFGGVDddeavATIRAALDLGINYIDTAPAYGDsEERLGLALA------ELPREPLVLSTKV-GRLPE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 402478636  77 KSLVETACR------KSLKALKLNYLDLYLIHwpmgfKPPHPEW 114
Cdd:cd19090   74 DTADYSADRvrrsveESLERLGRDRIDLLMIH-----DPERVPW 112

AKR_AKR13A_13D

cd19076

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...

24-102

3.64e-08

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 52.60 E-value: 3.64e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  24 KEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK---LWCTCHKK-------SLVETACRKSLKA 90
Cdd:cd19076   39 HRALELGVTFLDTADMYgpgTNEELLGKALK-------DRRDEVVIATKfgiVRDPGSGFrgvdgrpEYVRAACEASLKR 111

                         90
                 ....*....|..
gi 402478636  91 LKLNYLDLYLIH 102
Cdd:cd19076  112 LGTDVIDLYYQH 123

AKR_Tas-like

cd19094

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...

26-104

1.94e-07

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.

Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 50.64 E-value: 1.94e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  26 AIDAGYRHFDCAYFY----------HNEREVGAGIRCKikegaVRREDLFIATKL--------WC----TCHKKSLVETA 83
Cdd:cd19094   27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKK-----GNRDKVVLATKVagpgegitWPrgggTRLDRENIREA 101

                         90       100
                 ....*....|....*....|.
gi 402478636  84 CRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19094  102 VEGSLKRLGTDYIDLYQLHWP 122

AKR_AKR11B2

cd19149

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...

3-104

4.73e-07

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 49.19 E-value: 4.73e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPAVGLSSWKA----SPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRCkikegavRREDLFIATKl 70
Cdd:cd19149   10 EASVIGLGTWAIgggpWWGGSDDnesirTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKG-------RRDKVVLATK- 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 402478636  71 wC------------------TCHK----KSLVETaCRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19149   82 -CglrwdreggsfffvrdgvTVYKnlspESIREE-VEQSLKRLGTDYIDLYQTHWQ 135

AKR_AKR11B1

cd19148

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...

3-104

7.39e-07

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 48.84 E-value: 7.39e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   3 DIPA--VGLSSWK--------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGAVRREDLFIATK 69
Cdd:cd19148    1 DLPVsrIALGTWAiggwmwggTDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIATK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 402478636  70 L---WCTCHKKSLVETACR------KSLKALKLNYLDLYLIHWP 104
Cdd:cd19148   76 VgleWDEGGEVVRNSSPARirkeveDSLRRLQTDYIDLYQVHWP 119

AKR_AKR12A1_B1_C1

cd19087

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...

24-102

8.60e-07

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.

Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 48.34 E-value: 8.60e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  24 KEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATKL------WCTCHKKSL--VETACRKSLKALK 92
Cdd:cd19087   37 DRALDAGINFFDTADVYgggRSEEIIGRWI-------AGRRDDIVLATKVfgpmgdDPNDRGLSRrhIRRAVEASLRRLQ 109

                         90
                 ....*....|
gi 402478636  93 LNYLDLYLIH 102
Cdd:cd19087  110 TDYIDLYQMH 119

AKR_AKR13C1_2

cd19078

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...

20-102

1.75e-06

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.

Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 47.61 E-value: 1.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  20 TEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATKLWCTCHKKSLVET-----------ACR 85
Cdd:cd19078   28 IELIRKAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKFGFKIDGGKPGPLgldsrpehirkAVE 100

                         90
                 ....*....|....*..
gi 402478636  86 KSLKALKLNYLDLYLIH 102
Cdd:cd19078  101 GSLKRLQTDYIDLYYQH 117

AKR_AKR6B1

cd19142

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...

4-102

2.08e-06

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.

Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 47.46 E-value: 2.08e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWKASPGKVTEAVKEAI-----DAGYRHFDCAYFYHNER-EVGAG-IrckIKEGAVRREDLFIATKL-W---- 71
Cdd:cd19142   13 VSNVGLGTWSTFSTAISEEQAEEIvtlayENGINYFDTSDAFTSGQaETELGrI---LKKKGWKRSSYIVSTKIyWsygs 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 402478636  72 --CTCHKKSLVEtACRKSLKALKLNYLDLYLIH 102
Cdd:cd19142   90 eeRGLSRKHIIE-SVRASLRRLQLDYIDIVIIH 121

AKR_AKR13D1

cd19145

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...

8-102

2.16e-06

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 47.43 E-value: 2.16e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVTEA---VKEAIDAGYRHFDCAYFY---HNEREVGAGIrckiKEGavRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19145   21 GLSGDYGAPKPEEEGialIHHAFNSGVTFLDTSDIYgpnTNEVLLGKAL----KDG--PREKVQLATKFGIHEIGGSGVE 94

                         90       100       110
                 ....*....|....*....|....*....|
gi 402478636  82 ---------TACRKSLKALKLNYLDLYLIH 102
Cdd:cd19145   95 vrgdpayvrAACEASLKRLDVDYIDLYYQH 124

AKR_unchar

cd19101

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

14-103

3.43e-06

Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 46.82 E-value: 3.43e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  14 ASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKlWCT-----CHKKSLVETACRKSL 88
Cdd:cd19101   20 RDEDAAVRAMAAYVDAGLTTFDCADIYGPAEELIGEFRKRLRRERDAADDVQIHTK-WVPdpgelTMTRAYVEAAIDRSL 98

                         90
                 ....*....|....*
gi 402478636  89 KALKLNYLDLYLIHW 103
Cdd:cd19101   99 KRLGVDRLDLVQFHW 113

AKR_unchar

cd19097

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

17-104

5.20e-06

Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 45.98 E-value: 5.20e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  17 GKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGagirckikEGAVRREDLFIATKL----WCTCHKKSLVETACRK 86
Cdd:cd19097   21 GKPSEKeakkiLEYALKAGINTLDTAPAYGDsEKVLG--------KFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEA 92

                         90
                 ....*....|....*...
gi 402478636  87 SLKALKLNYLDLYLIHWP 104
Cdd:cd19097   93 SLKRLKVDSLDGLLLHNP 110

AKR_AKR10A1_2

cd19082

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...

27-102

1.58e-05

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.

Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 44.85 E-value: 1.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  27 IDAGYRHFDCAYFY-------HNEREVGAGIRCKIKegavrREDLFIATK-----LWCT----CHKKSLVEtACRKSLKA 90
Cdd:cd19082   27 VELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-----RDKVVIATKgghpdLEDMsrsrLSPEDIRA-DLEESLER 100

                         90
                 ....*....|..
gi 402478636  91 LKLNYLDLYLIH 102
Cdd:cd19082  101 LGTDYIDLYFLH 112

AKR_unchar

cd19104

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

22-102

2.47e-05

Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 44.18 E-value: 2.47e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  22 AVKEAIDAGYRHFDCAYFY---HNER-------EVGAGIR--CKIKEGAVRREDLfiatklwctchkKSLVETACRKSLK 89
Cdd:cd19104   37 AVRRALDLGINFFDTAPSYgdgKSEEnlgralkGLPAGPYitTKVRLDPDDLGDI------------GGQIERSVEKSLK 104

                         90
                 ....*....|...
gi 402478636  90 ALKLNYLDLYLIH 102
Cdd:cd19104  105 RLKRDSVDLLQLH 117

AKR_AKR13A1

cd19144

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...

6-102

2.97e-05

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.

Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 43.97 E-value: 2.97e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   6 AVGLSSWKASPGKVTEAVK---EAIDAGYRHFDCAYFY-HNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKS--- 78
Cdd:cd19144   20 AMGLSAFYGPPKPDEERFAvldAAFELGCTFWDTADIYgDSEELIGRWF----KQNPGKREKIFLATKFGIEKNVETgey 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 402478636  79 -------LVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19144   96 svdgspeYVKKACETSLKRLGVDYIDLYYQH 126

AKR_AKR13B1

cd19088

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...

23-112

3.01e-05

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.

Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 43.75 E-value: 3.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATKL---------WCTCHKKSLVETACRKSLKA 90
Cdd:cd19088   30 LRRALELGVNFIDTADSYgpdVNERLIAEALH-------PYPDDVVIATKGglvrtgpgwWGPDGSPEYLRQAVEASLRR 102

                         90       100
                 ....*....|....*....|..
gi 402478636  91 LKLNYLDLYLIHWPMgfkPPHP 112
Cdd:cd19088  103 LGLDRIDLYQLHRID---PKVP 121

AKR_AKR9A_9B

cd19080

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...

27-111

3.75e-05

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.

Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 43.75 E-value: 3.75e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  27 IDAGYRHFDCAYFYHN---EREVGAGIrckikegAVRREDLFIATKL----------WCTCHKKSLVEtACRKSLKALKL 93
Cdd:cd19080   41 VEAGGNFIDTANNYTNgtsERLLGEFI-------AGNRDRIVLATKYtmnrrpgdpnAGGNHRKNLRR-SVEASLRRLQT 112

                         90
                 ....*....|....*...
gi 402478636  94 NYLDLYLIHWPMGFKPPH 111
Cdd:cd19080  113 DYIDLLYVHAWDFTTPVE 130

AKR_AKR14A1_2

cd19089

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...

4-102

6.37e-05

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.

Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 43.01 E-value: 6.37e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   4 IPAVGLSSWK-----ASPGKVTEAVKEAIDAGYRHFDCAYFY-----HNEREVGAGIRckiKEGAVRREDLFIATKLWCT 73
Cdd:cd19089   11 LPAISLGLWHnfgdyTSPEEARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILK---RDLRPYRDELVISTKAGYG 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 402478636  74 CH---------KKSLVETaCRKSLKALKLNYLDLYLIH 102
Cdd:cd19089   88 MWpgpygdggsRKYLLAS-LDQSLKRMGLDYVDIFYHH 124

AKR_ARA2

cd19164

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...

18-102

8.34e-05

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 42.65 E-value: 8.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  18 KVTEAVKEAIDAGYRHFDCAYFYHnEREVGAGIRCKIKEGAVRREDLFIATKlwctCHKKSL---------VETACRKSL 88
Cdd:cd19164   35 PPVDIVRRALELGIRAFDTSPYYG-PSEIILGRALKALRDEFPRDTYFIITK----VGRYGPddfdyspewIRASVERSL 109

                         90
                 ....*....|....
gi 402478636  89 KALKLNYLDLYLIH 102
Cdd:cd19164  110 RRLHTDYLDLVYLH 123

AKR_AKR7A1-5

cd19075

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...

8-104

9.80e-05

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.

Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 42.16 E-value: 9.80e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVT-EAVKEAIDA----GYRHFDCAYFYHN---ER---EVGAGIRckikegavrreDLFIATK---LWCT 73
Cdd:cd19075    6 GTMTFGSQGRFTTaEAAAELLDAflerGHTEIDTARVYPDgtsEEllgELGLGER-----------GFKIDTKanpGVGG 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 402478636  74 CHKKSLVETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19075   75 GLSPENVRKQLETSLKRLKVDKVDVFYLHAP 105

AKR_AKR15A

cd19152

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...

7-70

1.02e-04

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.

Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 42.21 E-value: 1.02e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402478636   7 VGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL 70
Cdd:cd19152    5 FGTAPLgnlyeAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR------ELGREDYVISTKV 70

AKR_galDH

cd19163

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...

8-102

1.10e-04

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).

Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 42.15 E-value: 1.10e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   8 GLSSWKASPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKL--WCTCHKK 77
Cdd:cd19163   19 GASPLGGVFGPVDEeeairTVHEALDSGINYIDTAPWYgqgRSETVLGKALK------GIPRDSYYLATKVgrYGLDPDK 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 402478636  78 SLVETACR------KSLKALKLNYLDLYLIH 102
Cdd:cd19163   93 MFDFSAERitksveESLKRLGLDYIDIIQVH 123

AKR_unchar

cd19103

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

15-105

1.22e-04

Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 41.94 E-value: 1.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  15 SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLWCTCHKKSL--VETACRKSLK 89
Cdd:cd19103   30 DEDTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLK------RYPREDYIISTKFTPQIAGQSAdpVADMLEGSLA 103

                         90
                 ....*....|....*.
gi 402478636  90 ALKLNYLDLYLIHWPM 105
Cdd:cd19103  104 RLGTDYIDIYWIHNPA 119

AKR_galDH-like

cd19153

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...

6-102

2.44e-04

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 40.98 E-value: 2.44e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636   6 AVGLSSWKASPGKVTEA---VKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikEGAVRREDLFIATKLwctCHKKS- 78
Cdd:cd19153   19 TAALGGVYGDGLEQDEAvaiVAEAFAAGINHFDTSPYYGAessEAVLGKALA----ALQVPRSSYTVATKV---GRYRDs 91

                         90       100       110
                 ....*....|....*....|....*....|.
gi 402478636  79 -------LVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19153   92 efdysaeRVRASVATSLERLHTTYLDVVYLH 122

AKR_AKR8A1-2

cd19077

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...

164-195

1.01e-03

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).

Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 39.14 E-value: 1.01e-03

                         10        20        30
                 ....*....|....*....|....*....|..
gi 402478636 164 VIVIPGSITPSHIKENIQVFDFELTQHDMDNI 195
Cdd:cd19077  270 IIPIPGSTTLERVEENLKAANVELTDEELKEI 301

PLN02587

L-galactose dehydrogenase

21-102

3.76e-03

L-galactose dehydrogenase

Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 37.45 E-value: 3.76e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402478636  21 EAVKEAIDAGYRHFDCAYFYHN---EREVGAGirckIKEGAVRREDLFIATKlwCTCHKKSLVETACR------KSLKAL 91
Cdd:PLN02587  35 ASVREAFRLGINFFDTSPYYGGtlsEKVLGKA----LKALGIPREKYVVSTK--CGRYGEGFDFSAERvtksvdESLARL 108

                         90
                 ....*....|.
gi 402478636  92 KLNYLDLYLIH 102
Cdd:PLN02587 109 QLDYVDILHCH 119

AKR_unchar

cd19752

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

60-102

3.86e-03

Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 37.31 E-value: 3.86e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402478636  60 RREDLFIATKL---------WCTCH---KKSLVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19752   65 NRDDVVIATKVgagprdpdgGPESPeglSAETIEQEIDKSLRRLGTDYIDLYYAH 119

AKR_AKR9C1

cd19081

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...

60-104

4.65e-03

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).

Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 37.19 E-value: 4.65e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 402478636  60 RREDLFIATKL--WCTCHKKSL----VETACRKSLKALKLNYLDLYLIHWP 104
Cdd:cd19081   74 KRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRRLQTDYIDLYQAHWD 124

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01